Author results

5JJU
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CRYSTAL STRUCTURE OF RV2837C COMPLEXED WITH 5'-PAPA AND 5'-AMP
Descriptor:Uncharacterized protein Rv2837c, RNA (5'-R(P*AP*A)-3'), MANGANESE (II) ION, ...
Authors:Wang, F., He, Q., Liu, S., Gu, L.
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase
J.Biol.Chem., 291, 2016
5CET
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CRYSTAL STRUCTURE OF RV2837C
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
Authors:Wang, F., He, Q., Zhu, D., Liu, S., Gu, L.
Deposit date:2015-07-07
Release date:2015-12-23
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase
J.Biol.Chem., 291, 2016
4GZR
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CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS H37RV ESXOP (RV2346C-RV2347C) COMPLEX IN SPACE GROUP C2221
Descriptor:ESAT-6-like protein 6, ESAT-6-like protein 7, SULFATE ION
Authors:Arbing, M.A., Chan, S., He, Q., Harris, L., Zhou, T.T., Kuo, E., Ahn, C.J., Eisenberg, D., TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI)
Deposit date:2012-09-06
Release date:2012-09-26
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.553 Å)
Cite:Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
4QKB
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CRYSTAL STRUCTURE OF SELENO-METHIONINE LABELLED HUMAN ALKBH7 IN COMPLEX WITH ALPHA-KETOGLUTARATE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., He, Q., Chen, Z.
Deposit date:2014-06-05
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
5XHX
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CRYSTAL STRUCTURE OF VQSR LBD DOMAIN FROM PSEUDOMONAS AERUGINOSA
Descriptor:Helix-turn-helix transcriptional regulator
Authors:Gu, L., He, Q., Wang, K., Wang, F.
Deposit date:2017-04-24
Release date:2017-05-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of VqsR LBD domain from Pseudomonas aeruginosa
To Be Published
5XSR
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NOVEL ORALLY EFFICACIOUS INHIBITORS COMPLEXED WITH PARP1
Descriptor:Poly [ADP-ribose] polymerase 1, 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, SULFATE ION
Authors:Liu, Q., Xu, Y.
Deposit date:2017-06-15
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
5XST
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NOVEL ORALLY EFFICACIOUS INHIBITORS COMPLEXED WITH PARP1
Descriptor:Poly [ADP-ribose] polymerase 1, 6-fluoranyl-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide, SULFATE ION
Authors:Liu, Q., Xu, Y.
Deposit date:2017-06-15
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
5XSU
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NOVEL ORALLY EFFICACIOUS INHIBITORS COMPLEXED WITH PARP1
Descriptor:Poly [ADP-ribose] polymerase 1, SULFATE ION, 6-fluoranyl-2-(4,5,6,7-tetrahydrofuro[2,3-c]pyridin-2-yl)-1~{H}-benzimidazole-4-carboxamide
Authors:Liu, Q., Xu, Y.
Deposit date:2017-06-15
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
Eur J Med Chem, 145, 2018
1CKT
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CRYSTAL STRUCTURE OF HMG1 DOMAIN A BOUND TO A CISPLATIN-MODIFIED DNA DUPLEX
Descriptor:DNA (5'-D(*CP*CP*(5IU)P*CP*TP*CP*TP*GP*GP*AP*CP*CP*TP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*GP*TP*CP*CP*AP*GP*AP*GP*AP*GP*G)-3'), HIGH MOBILITY GROUP 1 PROTEIN, ...
Authors:Ohndorf, U.-M., Rould, M.A., Pabo, C.O., Lippard, S.J.
Deposit date:1999-04-23
Release date:1999-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.
Nature, 399, 1999
3OGI
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CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS H37RV ESXOP COMPLEX (RV2346C-RV2347C)
Descriptor:Putative ESAT-6-like protein 6, Putative ESAT-6-like protein 7
Authors:Arbing, M.A., Chan, S., Zhou, T.T., Ahn, C., Harris, L., Kuo, E., Sawaya, M.R., Cascio, D., Eisenberg, D., Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-08-16
Release date:2010-08-25
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
3Q4H
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CRYSTAL STRUCTURE OF THE MYCOBACTERIUM SMEGMATIS ESXGH COMPLEX (MSMEG_0620-MSMEG_0621)
Descriptor:Pe family protein, Low molecular weight protein antigen 7
Authors:Chan, S., Harris, L., Kuo, E., Ahn, C., Zhou, T.T., Nguyen, L., Shin, A., Sawaya, M.R., Cascio, D., Arbing, M.A., Eisenberg, D., Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-12-23
Release date:2011-01-26
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
4I0X
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CRYSTAL STRUCTURE OF THE MYCOBACTERUM ABSCESSUS ESXEF (MAB_3112-MAB_3113) COMPLEX
Descriptor:ESAT-6-like protein MAB_3112, ESAT-6-like protein MAB_3113, SULFATE ION, ...
Authors:Arbing, M.A., Chan, S., Lu, J., Kuo, E., Harris, L., Eisenberg, D., Integrated Center for Structure and Function Innovation (ISFI), TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-11-19
Release date:2013-01-16
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (1.956 Å)
Cite:Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions.
Plos One, 8, 2013
4OVA
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STRUCTURE OF THE TWO TANDEM TUDOR DOMAINS AND A NEW IDENTIFIED KH0 DOMAIN FROM HUMAN FRAGILE X MENTAL RETARDATION PROTEIN
Descriptor:Fragile X mental retardation protein 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Chen, Z.H., Chen, Z.Z.
Deposit date:2014-02-21
Release date:2015-02-25
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:The amino-terminal structure of human fragile X mental retardation protein obtained using precipitant-immobilized imprinted polymers
Nat Commun, 6, 2015
4QKD
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CRYSTAL STRUCTURE OF HUMAN ALKBH7 IN COMPLEX WITH ALPHA-KETOGLUTARATE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., Chen, Z.
Deposit date:2014-06-06
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
4QKF
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CRYSTAL STRUCTURE OF HUMAN ALKBH7 IN COMPLEX WITH N-OXALYLGLYCINE AND MN(II)
Descriptor:Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial, MANGANESE (II) ION, ...
Authors:Wang, G., Chen, Z.
Deposit date:2014-06-06
Release date:2014-08-20
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism
J.Biol.Chem., 289, 2014
5EJL
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MRKH, A NOVEL C-DI-GMP DEPENDENCE TRANSCRIPTION REGULATORY FACTOR.
Descriptor:Klebsiella pneumoniae genome assembly NOVST, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SULFATE ION, ...
Authors:Wang, F., Zhu, D., Gu, L.
Deposit date:2015-11-02
Release date:2016-10-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The PilZ domain of MrkH represents a novel DNA binding motif
Protein Cell, 7, 2016
5IZU
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A NEW BINDING SITE OUTSIDE THE CANONICAL PDZ DOMAIN DETERMINES THE SPECIFIC INTERACTION BETWEEN SHANK AND SAPAP AND THEIR FUNCTION
Descriptor:SH3 and multiple ankyrin repeat domains protein 3, peptide from Disks large-associated protein 3
Authors:Shang, Y., Zeng, M., Zhang, M.
Deposit date:2016-03-26
Release date:2016-05-18
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proc.Natl.Acad.Sci.USA, 113, 2016
5XBI
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THE STRUCTURE OF BRLR-C DOMAIN BOUND TO 3-AMINO-2-PHENAZINO(A PYOCYANIN ANALOG)
Descriptor:Probable transcriptional regulator, 3-azanylphenazin-2-ol, DI(HYDROXYETHYL)ETHER
Authors:Wang, F., Qing, H., Gu, L.
Deposit date:2017-03-17
Release date:2018-03-21
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin.
Nat Commun, 9, 2018
5XBT
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THE STRUCTURE OF BRLR BOUND TO C-DI-GMP
Descriptor:Probable transcriptional regulator, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GLYCEROL, ...
Authors:Wang, F., Qing, H., Gu, L.
Deposit date:2017-03-21
Release date:2018-05-02
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin.
Nat Commun, 9, 2018
5XBW
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THE STRUCTURE OF BRLR
Descriptor:Probable transcriptional regulator
Authors:Wang, F., Qing, H., Gu, L.
Deposit date:2017-03-21
Release date:2018-05-02
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.109 Å)
Cite:BrlR from Pseudomonas aeruginosa is a receptor for both cyclic di-GMP and pyocyanin.
Nat Commun, 9, 2018
5XFN
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STRUCTURE OF THE N-TERMINAL DOMAINS OF PHF1
Descriptor:PHD finger protein 1, ZINC ION
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFO
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STRUCTURE OF THE N-TERMINAL DOMAINS OF PHF1
Descriptor:PHD finger protein 1, ZINC ION
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFP
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BINARY COMPLEX OF PHF1 AND A DOUBLE STRANDED DNA
Descriptor:PHD finger protein 1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), ZINC ION, ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFQ
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TERNARY COMPLEX OF PHF1, A DNA DUPLEX AND A HISTONE PEPTIDE
Descriptor:PHD finger protein 1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), Peptide from Histone H3, ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
5XFR
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TERNARY COMPLEX OF MTF2, DNA AND HISTONE
Descriptor:Metal-response element-binding transcription factor 2, Peptide from Histone H3.1, DNA (5'-D(*GP*GP*GP*CP*GP*GP*CP*CP*GP*CP*CP*CP*T)-3'), ...
Authors:Wang, Z., Li, H.
Deposit date:2017-04-11
Release date:2017-09-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Polycomb-like proteins link the PRC2 complex to CpG islands
Nature, 549, 2017
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