6PQP

Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC

Summary for 6PQP

Entry DOI	10.2210/pdb6pqp/pdb
EMDB information	20449 20450 20451
Descriptor	Transient receptor potential cation channel subfamily A member 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ... (5 entities in total)
Functional Keywords	ion channel, trp channel, trpa channel, trpa1 channel, irritant sensing, bitc, membrane protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	545684.93
Authors	Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.-R.,Lee, S.-Y. (deposition date: 2019-07-09, release date: 2020-01-08, Last modification date: 2020-07-29)
Primary citation	Suo, Y.,Wang, Z.,Zubcevic, L.,Hsu, A.L.,He, Q.,Borgnia, M.J.,Ji, R.R.,Lee, S.Y. Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105:882-, 2020 Cited by PubMed: 31866091 DOI: 10.1016/j.neuron.2019.11.023 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.06 Å)

Structure validation