6PQP
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Transient receptor potential cation channel subfamily A member 1 | polymer | 1152 | 131495.5 | 4 | UniProt (O75762) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (Human) | Ankyrin-like with transmembrane domains protein 1,Transformation-sensitive protein p120 |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | EA, I, P, W (C, A, D, B) | N-benzylthioformamide | non-polymer | 151.2 | 4 | Chemie (9BE) | |||
| 4 | AA, CA, DA, FA, GA... (B, C, A, D) | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | non-polymer | 718.0 | 20 | Chemie (6OU) | |||
| 5 | BA, JA, N, T (B, C, A, D) | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine | non-polymer | 760.1 | 4 | Chemie (LBN) |
Sequence modifications
A, D, B, C: 2 - 1119 (UniProt: O75762)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Ser 1120 | - | expression tag |
| Asn 1121 | - | expression tag |
| Ser 1122 | - | expression tag |
| Leu 1123 | - | expression tag |
| Glu 1124 | - | expression tag |
| Val 1125 | - | expression tag |
| Leu 1126 | - | expression tag |
| Phe 1127 | - | expression tag |
| Gln 1128 | - | expression tag |
| Gly 1129 | - | expression tag |
| Pro 1130 | - | expression tag |
| Ala 1131 | - | expression tag |
| Ala 1132 | - | expression tag |
| Asp 1133 | - | expression tag |
| Tyr 1134 | - | expression tag |
| Lys 1135 | - | expression tag |
| Asp 1136 | - | expression tag |
| Asp 1137 | - | expression tag |
| Asp 1138 | - | expression tag |
| Asp 1139 | - | expression tag |
| Lys 1140 | - | expression tag |
| Ala 1141 | - | expression tag |
| His 1142 | - | expression tag |
| His 1143 | - | expression tag |
| His 1144 | - | expression tag |
| His 1145 | - | expression tag |
| His 1146 | - | expression tag |
| His 1147 | - | expression tag |
| His 1148 | - | expression tag |
| His 1149 | - | expression tag |
| His 1150 | - | expression tag |
| His 1151 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 525982.2 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 18005.1 | |
| All* | Total formula weight | 545684.9 |
