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1MRN
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)
Descriptor:Thymidylate Kinase, SULFATE ION, MAGNESIUM ION, ...
Authors:Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
1MRS
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE
Descriptor:THYMIDYLATE KINASE, SULFATE ION, MAGNESIUM ION, ...
Authors:Haouz, A., Vanheusden, V., Munier-Lehmann, H., Froeyen, M., Herdewijn, P., Van Calenbergh, S., Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
4NPP
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THE GLIC-HIS10 WILD-TYPE STRUCTURE IN EQUILIBRIUM BETWEEN THE OPEN AND LOCALLY-CLOSED (LC) FORMS
Descriptor:Proton-gated ion channel, NICKEL (II) ION
Authors:Sauguet, L., Shahsavar, A., Poitevin, F., Huon, C., Menny, A., Nemecz, A., Haouz, A., Changeux, J.P., Corringer, P.J., Delarue, M.
Deposit date:2013-11-22
Release date:2013-12-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NPQ
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THE RESTING-STATE CONFORMATION OF THE GLIC LIGAND-GATED ION CHANNEL
Descriptor:Proton-gated ion channel
Authors:Sauguet, L., Shahsavar, A., Poitevin, F., Huon, C., Menny, A., Nemecz, A., Haouz, A., Changeux, J.P., Corringer, P.J., Delarue, M.
Deposit date:2013-11-22
Release date:2013-12-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (4.35 Å)
Cite:Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
Proc.Natl.Acad.Sci.USA, 111, 2014
2CKD
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CRYSTAL STRUCTURE OF ML2640 FROM MYCOBACTERIUM LEPRAE
Descriptor:PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE ML2640
Authors:Grana, M., Buschiazzo, A., Wehenkel, A., Haouz, A., Alzari, P.M.
Deposit date:2006-04-17
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
Protein Sci., 16, 2007
2FWV
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CRYSTAL STRUCTURE OF RV0813
Descriptor:hypothetical protein MtubF_01000852, 1,4-DIETHYLENE DIOXIDE, GLYCEROL
Authors:Shepard, W., Haouz, A., Grana, M., Buschiazzo, A., Betton, J.M., Cole, S.T., Alzari, P.M., Structural Proteomics in Europe (SPINE)
Deposit date:2006-02-03
Release date:2006-08-03
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Rv0813c from Mycobacterium tuberculosis Reveals a New Family of Fatty Acid-Binding Protein-Like Proteins in Bacteria
J.Bacteriol., 189, 2007
2UYO
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CRYSTAL STRUCTURE OF ML2640C FROM MYCOBACTERIUM LEPRAE IN AN HEXAGONAL CRYSTAL FORM
Descriptor:HYPOTHETICAL PROTEIN ML2640
Authors:Grana, M., Buschiazzo, A., Wehenkel, A., Haouz, A., Miras, I., Shepard, W., Alzari, P.M.
Deposit date:2007-04-11
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
Protein Sci., 16, 2007
2UYQ
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CRYSTAL STRUCTURE OF ML2640C FROM MYCOBACTERIUM LEPRAE IN COMPLEX WITH S-ADENOSYLMETHIONINE
Descriptor:HYPOTHETICAL PROTEIN ML2640, S-ADENOSYLMETHIONINE
Authors:Grana, M., Buschiazzo, A., Wehenkel, A., Haouz, A., Miras, I., Shepard, W., Alzari, P.M.
Deposit date:2007-04-11
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
Protein Sci., 16, 2007
2V7S
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CRYSTAL STRUCTURE OF THE PUTATIVE LIPOPROTEIN LPPA FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:PROBABLE CONSERVED LIPOPROTEIN LPPA, GLYCEROL
Authors:Grana, M., Miras, I., Haouz, A., Winter, N., Buschiazzo, A., Bellinzoni, M., Alzari, P.M.
Deposit date:2007-08-01
Release date:2008-08-26
Last modified:2011-09-28
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structure of Mycobacterium Tuberculosis Lppa, a Lipoprotein Confined to Pathogenic Mycobacteria.
Proteins, 78, 2010
2WAM
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714
Descriptor:CONSERVED HYPOTHETICAL ALANINE AND LEUCINE RICH PROTEIN, GLYCEROL
Authors:Bellinzoni, M., Grana, M., Buschiazzo, A., Miras, I., Haouz, A., Alzari, P.M.
Deposit date:2009-02-09
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Mycobacterium Tuberculosis Rv2714, a Representative of a Duplicated Gene Family in Actinobacteria.
Acta Crystallogr.,Sect.F, 65, 2009
4EO3
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PEROXIREDOXIN NITROREDUCTASE FUSION ENZYME
Descriptor:Bacterioferritin comigratory protein/NADH dehydrogenase, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
Authors:Prosper, P., Haouz, A., Navaza, A., Jacquot, J.-P., Rouhier, N.
Deposit date:2012-04-13
Release date:2012-10-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
Antioxid Redox Signal, 18, 2013
4PQH
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE LAMBDA1 FROM POPULUS TRICHOCARPA
Descriptor:glutathione transferase lambda1, GLUTATHIONE, SODIUM ION
Authors:Lallement, P.A., Meux, E., Gualberto, J.M., Prosper, P., Didierjean, C., Haouz, A., Saul, F., Rouhier, N., Hecker, A.
Deposit date:2014-03-03
Release date:2014-06-25
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants.
Biochem.J., 462, 2014
4PQI
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CRYSTAL STRUCTURE OF GLUTATHIONE TRANSFERASE LAMBDA3 FROM POPULUS TRICHOCARPA
Descriptor:In2-1 family protein, glutathione transferase lambda3, GLUTATHIONE, ...
Authors:Lallement, P.A., Meux, E., Gualberto, J.M., Prosper, P., Didierjean, C., Haouz, A., Saul, F., Rouhier, N., Hecker, A.
Deposit date:2014-03-03
Release date:2014-06-25
Last modified:2014-08-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants.
Biochem.J., 462, 2014
4TR2
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CRYSTAL STRUCTURE OF PVSUB1
Descriptor:Subtilisin-like 1 serine protease, CALCIUM ION, PHOSPHATE ION
Authors:Giganti, D., Bouillon, A., Martinez, M., Weber, P., Girard-Blanc, C., Petres, S., Haouz, A., Barale, J.C., Alzari, P.M.
Deposit date:2014-06-13
Release date:2014-09-17
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase.
Nat Commun, 5, 2014
4USS
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POPULUS TRICHOCARPA GLUTATHIONE TRANSFERASE X1-1 (GHR1), COMPLEXED WITH GLUTATHIONE
Descriptor:GLUTATHIONYL HYDROQUINONE REDUCTASE, GLUTATHIONE, PHOSPHATE ION
Authors:Lallement, P.A., Meux, E., Gualberto, J.M., Dumaracay, S., Favier, F., Didierjean, C., Saul, F., Haouz, A., Morel-Rouhier, M., Gelhaye, E., Rouhier, N., Hecker, A.
Deposit date:2014-07-13
Release date:2014-12-03
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glutathionyl-Hydroquinone Reductases from Poplar are Plastidial Proteins that Deglutathionylate Both Reduced and Oxidized Glutathionylated Quinones.
FEBS Lett., 589, 2015
5NCR
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OH1 FROM THE ORF VIRUS: A TYROSINE PHOSPHATASE THAT DISPLAYS DISTINCT STRUCTURAL FEATURES AND TRIPLE SUBSTRATE SPECIFICITY
Descriptor:tyrosine phosphatase, PHOSPHATE ION, SULFATE ION
Authors:Segovia, D., Haouz, A., Berois, M., Villarino, A., Andre-Leroux, G.
Deposit date:2017-03-06
Release date:2017-08-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity.
J. Mol. Biol., 429, 2017
6H3S
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SCHMALLENBERG VIRUS GLYCOPROTEIN GC HEAD/STALK DOMAINS
Descriptor:Envelopment polyprotein, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.023 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6H3T
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SCHMALLENBERG VIRUS GLYCOPROTEIN GC HEAD DOMAIN IN COMPLEX WITH SCFV 1C11
Descriptor:scFv 1C11 VH, scFv 1C11 VL, Envelopment polyprotein, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.836 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6H3U
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SCHMALLENBERG VIRUS GLYCOPROTEIN GC HEAD DOMAIN IN COMPLEX WITH SCFV 4B6
Descriptor:scFv 4B6 VH, scFv 4B6 VL, Envelopment polyprotein, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3.168 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6H3V
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BUNYAMWERA VIRUS GLYCOPROTEIN GC HEAD DOMAIN
Descriptor:Envelopment polyprotein, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6H3W
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LA CROSSE VIRUS GLYCOPROTEIN GC HEAD DOMAIN
Descriptor:Envelopment polyprotein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6H3X
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OROPOUCHE VIRUS GLYCOPROTEIN GC HEAD DOMAIN
Descriptor:Polyprotein, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Hellert, J., Aebischer, A., Wernike, K., Haouz, A., Brocchi, E., Reiche, S., Guardado-Calvo, P., Beer, M., Rey, F.A.
Deposit date:2018-07-19
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
6HJE
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TRYPANOSOMA CRUZI PROLINE RACEMASE IN COMPLEX WITH INHIBITOR NG-P27
Descriptor:Proline racemase A, PHOSPHATE ION, 2-[(1~{S})-2-oxidanylidenecyclopentyl]ethanoic acid
Authors:Saul, F., Haouz, A., Uriac, P., Blondel, A., Minoprio, P.
Deposit date:2018-09-03
Release date:2018-11-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.
PLoS Negl Trop Dis, 12, 2018
6HJF
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TRYPANOSOMA CRUZI PROLINE RACEMASE IN COMPLEX WITH INHIBITOR BROXOPA
Descriptor:Proline racemase A, LAEVULINIC ACID
Authors:Saul, F., Haouz, A., Uriac, P., Blondel, A., Minoprio, P.
Deposit date:2018-09-03
Release date:2018-11-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.
PLoS Negl Trop Dis, 12, 2018
6HJG
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TRYPANOSOMA CRUZI PROLINE RACEMASE IN COMPLEX WITH INHIBITOR OXOPA
Descriptor:Proline racemase A, LAEVULINIC ACID, PHOSPHATE ION
Authors:Saul, F., Haouz, A., Uriac, P., Blondel, A., Minoprio, P.
Deposit date:2018-09-03
Release date:2018-11-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.
PLoS Negl Trop Dis, 12, 2018