6HJE

Trypanosoma cruzi proline racemase in complex with inhibitor NG-P27

Summary for 6HJE

• Entry DOI: 10.2210/pdb6hje/pdb
• Descriptor: Proline racemase A, PHOSPHATE ION, 2-[(1~{S})-2-oxidanylidenecyclopentyl]ethanoic acid, ... (4 entities in total)
• Functional Keywords: proline racemase, drug design, michael reaction, isomerase
• Biological source: Trypanosoma cruzi (strain CL Brener)
• Total number of polymer chains: 2
• Total formula weight: 91971.77

Authors

Saul, F.,Haouz, A.,Uriac, P.,Blondel, A.,Minoprio, P. (deposition date: 2018-09-03, release date: 2018-11-07, Last modification date: 2024-01-17)

• Primary citation: Amaral, P.A.,Autheman, D.,de Melo, G.D.,Gouault, N.,Cupif, J.F.,Goyard, S.,Dutra, P.,Coatnoan, N.,Cosson, A.,Monet, D.,Saul, F.,Haouz, A.,Uriac, P.,Blondel, A.,Minoprio, P.; Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography.; PLoS Negl Trop Dis, 12:e0006853-e0006853, 2018; PubMed: 30372428; DOI: 10.1371/journal.pntd.0006853

Experimental method

X-RAY DIFFRACTION (2 Å)