6TXR

Structural insights into cubane-modified aptamer recognition of a malaria biomarker

Summary for 6TXR

• Entry DOI: 10.2210/pdb6txr/pdb
• Descriptor: L-lactate dehydrogenase, ~{N}-[2-(1,2,3-triazol-1-yl)ethyl]cubane-1-carboxamide, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, ... (7 entities in total)
• Functional Keywords: aptamer, cubamer, pvldh, dna
• Biological source: Plasmodium vivax (malaria parasite P. vivax)
• Total number of polymer chains: 4
• Total formula weight: 161146.16

Authors

Cheung, Y.,Roethlisberger, P.,Mechaly, A.,Weber, P.,Wong, A.,Lo, Y.,Haouz, A.,Savage, P.,Hollenstein, M.,Tanner, J. (deposition date: 2020-01-14, release date: 2020-07-15, Last modification date: 2024-01-24)

• Primary citation: Cheung, Y.W.,Rothlisberger, P.,Mechaly, A.E.,Weber, P.,Levi-Acobas, F.,Lo, Y.,Wong, A.W.C.,Kinghorn, A.B.,Haouz, A.,Savage, G.P.,Hollenstein, M.,Tanner, J.A.; Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.; Proc.Natl.Acad.Sci.USA, 117:16790-16798, 2020; PubMed: 32631977; DOI: 10.1073/pnas.2003267117

Experimental method

X-RAY DIFFRACTION (2.5 Å)