6TXR

Structural insights into cubane-modified aptamer recognition of a malaria biomarker

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	L-lactate dehydrogenase	polymer	316	34260.9	4	UniProt (Q4PRK9) Pfam (PF00056) Pfam (PF02866)	Plasmodium vivax (malaria parasite P. vivax)	Lactate dehydrogenase,Parasite lactate dehydrogenase
2	DA, E, EA, F, OB... (B, A, D, C)	~{N}-[2-(1,2,3-triazol-1-yl)ethyl]cubane-1-carboxamide	non-polymer		242.3	8	Chemie (O0Q)
3	AA, AC, BA, DB, FB... (A, D, C, B)	2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE	non-polymer		347.2	22	Chemie (DG)
4	BC, GA, I, LA, O... (D, B, A, C)	2'-DEOXYURIDINE-5'-MONOPHOSPHATE	non-polymer		308.2	10	Chemie (DU)
5	AB, CA, EB, FA, HA... (C, A, B, D)	2'-DEOXYADENOSINE-5'-MONOPHOSPHATE	non-polymer		331.2	16	Chemie (DA)
6	BB, CB, IA, IB, JA... (C, B, A, D)	2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE	non-polymer		307.2	20	Chemie (DC)
7	CC, DC, EC, FC (A, B, C, D)	water	water		18.0	104	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137043.8
Non-Polymers*	Number of molecules	76
	Total formula weight	24102.4
All*	Total formula weight	161146.2

*Water molecules are not included.