6TXR
Structural insights into cubane-modified aptamer recognition of a malaria biomarker
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue DG E 1 |
| Chain | Residue |
| E | DG2 |
| E | DC23 |
| F | DG33 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue DG E 2 |
| Chain | Residue |
| E | O0Q502 |
| E | DG1 |
| E | DU3 |
| E | DA21 |
| E | DC22 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue DG E 7 |
| Chain | Residue |
| E | DC19 |
| E | DU20 |
| E | DA21 |
| E | DC22 |
| E | DA6 |
| E | DU17 |
| E | DA8 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue DA E 8 |
| Chain | Residue |
| E | DG7 |
| E | DC9 |
| E | DC10 |
| E | DG16 |
| E | DU17 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DC E 9 |
| Chain | Residue |
| A | LEU232 |
| E | DA8 |
| E | DC10 |
| E | DG14 |
| E | DG16 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue DC E 18 |
| Chain | Residue |
| A | ALA233 |
| A | SER234 |
| A | TYR236 |
| E | O0Q501 |
| E | DC19 |
| E | O0Q504 |
| E | DU17 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue DC E 19 |
| Chain | Residue |
| E | O0Q501 |
| E | DG7 |
| E | DC18 |
| E | DU20 |
| E | DU17 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue DA E 21 |
| Chain | Residue |
| E | DG2 |
| E | DU3 |
| E | DG7 |
| E | DU20 |
| E | DC22 |
| E | DA6 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue DC E 22 |
| Chain | Residue |
| E | DG2 |
| E | DG7 |
| E | DA21 |
| E | DC23 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue DC E 23 |
| Chain | Residue |
| E | DG1 |
| E | DC22 |
| E | DG24 |
| F | DG33 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue DG E 24 |
| Chain | Residue |
| E | DC23 |
| E | DA25 |
| F | DG32 |
| F | DG33 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue DA E 25 |
| Chain | Residue |
| E | DG24 |
| E | DG26 |
| F | DC31 |
| F | DG32 |
| F | DG33 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue DG E 26 |
| Chain | Residue |
| E | DA25 |
| E | DG27 |
| F | DA30 |
| F | DC31 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue DG E 27 |
| Chain | Residue |
| E | DG26 |
| E | DG28 |
| F | DC29 |
| F | DA30 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue DG E 28 |
| Chain | Residue |
| E | DG27 |
| E | DC29 |
| F | DG28 |
| F | DC29 |
| F | DA30 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue DC E 29 |
| Chain | Residue |
| E | DG28 |
| E | DA30 |
| F | DG27 |
| F | DG28 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue DA E 30 |
| Chain | Residue |
| E | DC29 |
| E | DC31 |
| F | DG26 |
| F | DG27 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue DC E 31 |
| Chain | Residue |
| E | DA30 |
| E | DG32 |
| F | DA25 |
| F | DG26 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue DG E 32 |
| Chain | Residue |
| E | DC31 |
| E | DG33 |
| F | DG24 |
| F | DA25 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue DG E 33 |
| Chain | Residue |
| E | DG32 |
| E | DA34 |
| F | DG1 |
| F | DC23 |
| F | DG24 |
| F | DA25 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue DA E 34 |
| Chain | Residue |
| E | DG33 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue DA E 4 |
| Chain | Residue |
| E | DU5 |
| E | DA6 |
| E | O0Q502 |
| E | DU3 |
| E | O0Q503 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue DA E 6 |
| Chain | Residue |
| E | DU3 |
| E | DG7 |
| E | DU20 |
| E | DA21 |
| E | DA4 |
| E | DU5 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue DC E 10 |
| Chain | Residue |
| E | DA8 |
| E | DC9 |
| B | LYS38 |
| E | DC11 |
| E | DU13 |
| E | DG14 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue DC E 11 |
| Chain | Residue |
| B | LYS38 |
| E | DC10 |
| E | DC12 |
| E | DU13 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue DC E 12 |
| Chain | Residue |
| E | DC11 |
| E | DU13 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue DU E 13 |
| Chain | Residue |
| B | LYS38 |
| E | DC10 |
| E | DC11 |
| E | DC12 |
| E | DG14 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue DG E 14 |
| Chain | Residue |
| E | DC9 |
| E | DC10 |
| E | DU13 |
| E | DA15 |
| E | DG16 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue DA E 15 |
| Chain | Residue |
| B | VAL36 |
| B | TYR67 |
| B | ALA80 |
| B | GLY81 |
| B | PHE82 |
| B | GLU108 |
| E | DG14 |
| E | DG16 |
| site_id | AF3 |
| Number of Residues | 9 |
| Details | binding site for residue DG E 16 |
| Chain | Residue |
| E | DA8 |
| E | DC9 |
| B | GLY13 |
| B | VAL37 |
| B | MET40 |
| E | O0Q504 |
| E | DG14 |
| E | DA15 |
| E | DU17 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 1 |
| Chain | Residue |
| E | DG33 |
| F | DG2 |
| F | DC22 |
| F | DC23 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue DG F 2 |
| Chain | Residue |
| F | O0Q502 |
| F | DG1 |
| F | DU3 |
| F | DA21 |
| F | DC22 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue DA F 8 |
| Chain | Residue |
| F | DC9 |
| F | DG7 |
| F | DG16 |
| F | DU17 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue DC F 9 |
| Chain | Residue |
| C | LEU232 |
| F | DA8 |
| F | DC10 |
| F | DG14 |
| F | DG16 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue DC F 18 |
| Chain | Residue |
| C | MET14 |
| C | ALA233 |
| C | SER234 |
| C | TYR236 |
| F | O0Q501 |
| F | DC19 |
| F | O0Q503 |
| F | DU17 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue DC F 19 |
| Chain | Residue |
| F | DC18 |
| F | DU20 |
| F | DG7 |
| F | DU17 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue DA F 21 |
| Chain | Residue |
| F | DG2 |
| F | DU3 |
| F | DU20 |
| F | DC22 |
| F | DA6 |
| F | DG7 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue DC F 22 |
| Chain | Residue |
| F | DG1 |
| F | DG2 |
| F | DA21 |
| F | DC23 |
| D | LYS207 |
| F | DG7 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue DC F 23 |
| Chain | Residue |
| E | DG33 |
| F | DG1 |
| F | DC22 |
| F | DG24 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 24 |
| Chain | Residue |
| E | DG32 |
| E | DG33 |
| F | DC23 |
| F | DA25 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue DA F 25 |
| Chain | Residue |
| E | DC31 |
| E | DG32 |
| E | DG33 |
| F | DG24 |
| F | DG26 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 26 |
| Chain | Residue |
| E | DA30 |
| E | DC31 |
| F | DA25 |
| F | DG27 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 27 |
| Chain | Residue |
| E | DC29 |
| E | DA30 |
| F | DG26 |
| F | DG28 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 28 |
| Chain | Residue |
| E | DG28 |
| E | DC29 |
| F | DG27 |
| F | DC29 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue DC F 29 |
| Chain | Residue |
| E | DG27 |
| E | DG28 |
| F | DG28 |
| F | DA30 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue DA F 30 |
| Chain | Residue |
| E | DG26 |
| E | DG27 |
| E | DG28 |
| F | DC29 |
| F | DC31 |
| F | HOH602 |
| F | HOH603 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue DC F 31 |
| Chain | Residue |
| E | DA25 |
| E | DG26 |
| F | DA30 |
| F | DG32 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue DG F 32 |
| Chain | Residue |
| E | DG24 |
| E | DA25 |
| F | DC31 |
| F | DG33 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue DG F 33 |
| Chain | Residue |
| E | DG1 |
| E | DC23 |
| E | DG24 |
| E | DA25 |
| F | DG32 |
| F | DA34 |
| site_id | AH5 |
| Number of Residues | 1 |
| Details | binding site for residue DA F 34 |
| Chain | Residue |
| F | DG33 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue DA F 4 |
| Chain | Residue |
| F | O0Q502 |
| F | DU3 |
| F | O0Q504 |
| F | DU5 |
| F | DA6 |
| F | HOH605 |
| site_id | AH7 |
| Number of Residues | 7 |
| Details | binding site for residue DA F 6 |
| Chain | Residue |
| F | DU3 |
| F | DU20 |
| F | DA21 |
| D | LYS84 |
| F | DA4 |
| F | DU5 |
| F | DG7 |
| site_id | AH8 |
| Number of Residues | 7 |
| Details | binding site for residue DG F 7 |
| Chain | Residue |
| F | DA8 |
| F | DC19 |
| F | DU20 |
| F | DA21 |
| F | DC22 |
| F | DA6 |
| F | DU17 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue DC F 10 |
| Chain | Residue |
| F | DC9 |
| F | DC11 |
| F | DU13 |
| F | DG14 |
| site_id | AI1 |
| Number of Residues | 6 |
| Details | binding site for residue DC F 11 |
| Chain | Residue |
| C | GLY269 |
| C | HIS270 |
| D | LYS38 |
| F | DC10 |
| F | DC12 |
| F | DU13 |
| site_id | AI2 |
| Number of Residues | 2 |
| Details | binding site for residue DC F 12 |
| Chain | Residue |
| F | DC11 |
| F | DU13 |
| site_id | AI3 |
| Number of Residues | 4 |
| Details | binding site for residue DU F 13 |
| Chain | Residue |
| F | DC10 |
| F | DC11 |
| F | DC12 |
| F | DG14 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue DG F 14 |
| Chain | Residue |
| F | DC9 |
| F | DC10 |
| F | DU13 |
| F | DA15 |
| F | DG16 |
| site_id | AI5 |
| Number of Residues | 9 |
| Details | binding site for residue DA F 15 |
| Chain | Residue |
| D | VAL36 |
| D | TYR67 |
| D | ALA80 |
| D | GLY81 |
| D | PHE82 |
| D | ILE105 |
| D | GLU108 |
| F | DG14 |
| F | DG16 |
| site_id | AI6 |
| Number of Residues | 10 |
| Details | binding site for residue DG F 16 |
| Chain | Residue |
| F | DA8 |
| F | DC9 |
| D | GLY13 |
| D | VAL37 |
| D | MET40 |
| F | O0Q503 |
| F | DG14 |
| F | DA15 |
| F | DU17 |
| F | HOH604 |
| site_id | AI7 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q A 401 and DU A 411 |
| Chain | Residue |
| A | MET14 |
| E | DG7 |
| E | DC18 |
| E | DC19 |
| E | DA21 |
| B | LEU232 |
| E | O0Q503 |
| E | DU5 |
| E | DA6 |
| site_id | AI8 |
| Number of Residues | 6 |
| Details | binding site for Di-nucleotide O0Q A 402 and DU A 405 |
| Chain | Residue |
| A | LYS38 |
| E | DG2 |
| E | DA21 |
| E | O0Q503 |
| E | DA4 |
| E | DA6 |
| site_id | AI9 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q B 401 and DU B 404 |
| Chain | Residue |
| A | ASN39 |
| E | O0Q501 |
| E | O0Q502 |
| E | DU20 |
| B | LEU231 |
| B | LEU232 |
| E | O0Q504 |
| E | DA4 |
| E | DA6 |
| site_id | AJ1 |
| Number of Residues | 11 |
| Details | binding site for Di-nucleotide O0Q B 402 and DU B 413 |
| Chain | Residue |
| E | DG7 |
| E | DA8 |
| E | DC18 |
| E | DC19 |
| B | GLY13 |
| B | MET14 |
| B | MET40 |
| B | LYS44 |
| B | ALA233 |
| E | DU5 |
| E | DG16 |
| site_id | AJ2 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q C 401 and DU C 410 |
| Chain | Residue |
| C | MET14 |
| F | DC18 |
| F | DC19 |
| F | DA21 |
| D | LEU232 |
| F | O0Q504 |
| F | DU5 |
| F | DA6 |
| F | DG7 |
| site_id | AJ3 |
| Number of Residues | 7 |
| Details | binding site for Di-nucleotide O0Q C 402 and DU C 405 |
| Chain | Residue |
| C | VAL37 |
| F | DG2 |
| F | DA21 |
| F | HOH601 |
| F | O0Q504 |
| F | DA4 |
| F | DA6 |
| site_id | AJ4 |
| Number of Residues | 11 |
| Details | binding site for Di-nucleotide O0Q D 401 and DU D 414 |
| Chain | Residue |
| F | DA8 |
| F | DC18 |
| F | DC19 |
| D | GLY13 |
| D | MET14 |
| D | LYS44 |
| D | ALA233 |
| F | O0Q504 |
| F | DU5 |
| F | DG7 |
| F | DG16 |
| site_id | AJ5 |
| Number of Residues | 12 |
| Details | binding site for Di-nucleotide O0Q D 402 and DU D 404 |
| Chain | Residue |
| C | VAL37 |
| C | ASN39 |
| C | MET40 |
| F | O0Q501 |
| F | O0Q502 |
| F | DU20 |
| D | ASN230 |
| D | LEU231 |
| D | LEU232 |
| F | O0Q503 |
| F | DA4 |
| F | DA6 |
