6TXR
Structural insights into cubane-modified aptamer recognition of a malaria biomarker
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| C | 0006089 | biological_process | lactate metabolic process |
| C | 0006090 | biological_process | pyruvate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| D | 0006089 | biological_process | lactate metabolic process |
| D | 0006090 | biological_process | pyruvate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue DG A 403 |
| Chain | Residue |
| A | DG404 |
| A | DC414 |
| C | DG423 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue DG A 404 |
| Chain | Residue |
| A | O0Q402 |
| A | DG403 |
| A | DU405 |
| A | DA412 |
| A | DC413 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue DG A 406 |
| Chain | Residue |
| A | DC410 |
| A | DU411 |
| A | DA412 |
| A | DC413 |
| B | DA405 |
| B | DU413 |
| A | DA407 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue DA A 407 |
| Chain | Residue |
| A | DG406 |
| A | DC408 |
| B | DC406 |
| B | DG412 |
| B | DU413 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DC A 408 |
| Chain | Residue |
| A | LEU232 |
| A | DA407 |
| B | DC406 |
| B | DG410 |
| B | DG412 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue DC A 409 |
| Chain | Residue |
| A | ALA233 |
| A | SER234 |
| A | TYR236 |
| A | O0Q401 |
| A | DC410 |
| B | O0Q402 |
| B | DU413 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue DC A 410 |
| Chain | Residue |
| A | O0Q401 |
| A | DG406 |
| A | DC409 |
| A | DU411 |
| B | DU413 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue DA A 412 |
| Chain | Residue |
| A | DG404 |
| A | DU405 |
| A | DG406 |
| A | DU411 |
| A | DC413 |
| B | DA405 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue DC A 413 |
| Chain | Residue |
| A | DG404 |
| A | DG406 |
| A | DA412 |
| A | DC414 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue DC A 414 |
| Chain | Residue |
| A | DG403 |
| A | DC413 |
| A | DG415 |
| C | DG423 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue DG A 415 |
| Chain | Residue |
| A | DC414 |
| A | DA416 |
| C | DG422 |
| C | DG423 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue DA A 416 |
| Chain | Residue |
| A | DG415 |
| A | DG417 |
| C | DC421 |
| C | DG422 |
| C | DG423 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue DG A 417 |
| Chain | Residue |
| A | DA416 |
| A | DG418 |
| C | DA420 |
| C | DC421 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue DG A 418 |
| Chain | Residue |
| A | DG417 |
| A | DG419 |
| C | DC419 |
| C | DA420 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue DG A 419 |
| Chain | Residue |
| A | DG418 |
| A | DC420 |
| C | DG418 |
| C | DC419 |
| C | DA420 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue DC A 420 |
| Chain | Residue |
| A | DG419 |
| A | DA421 |
| C | DG417 |
| C | DG418 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue DA A 421 |
| Chain | Residue |
| A | DC420 |
| A | DC422 |
| C | DG416 |
| C | DG417 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue DC A 422 |
| Chain | Residue |
| A | DA421 |
| A | DG423 |
| C | DA415 |
| C | DG416 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue DG A 423 |
| Chain | Residue |
| A | DC422 |
| A | DG424 |
| C | DG414 |
| C | DA415 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue DG A 424 |
| Chain | Residue |
| A | DG423 |
| A | DA425 |
| C | DG403 |
| C | DC413 |
| C | DG414 |
| C | DA415 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue DA A 425 |
| Chain | Residue |
| A | DG424 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue DA B 403 |
| Chain | Residue |
| B | DU404 |
| B | DA405 |
| A | O0Q402 |
| A | DU405 |
| B | O0Q401 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue DA B 405 |
| Chain | Residue |
| A | DU405 |
| A | DG406 |
| A | DU411 |
| A | DA412 |
| B | DA403 |
| B | DU404 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue DC B 406 |
| Chain | Residue |
| A | DA407 |
| A | DC408 |
| B | LYS38 |
| B | DC407 |
| B | DU409 |
| B | DG410 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue DC B 407 |
| Chain | Residue |
| B | LYS38 |
| B | DC406 |
| B | DC408 |
| B | DU409 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue DC B 408 |
| Chain | Residue |
| B | DC407 |
| B | DU409 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue DU B 409 |
| Chain | Residue |
| B | LYS38 |
| B | DC406 |
| B | DC407 |
| B | DC408 |
| B | DG410 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue DG B 410 |
| Chain | Residue |
| A | DC408 |
| B | DC406 |
| B | DU409 |
| B | DA411 |
| B | DG412 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue DA B 411 |
| Chain | Residue |
| B | VAL36 |
| B | TYR67 |
| B | ALA80 |
| B | GLY81 |
| B | PHE82 |
| B | GLU108 |
| B | DG410 |
| B | DG412 |
| site_id | AF3 |
| Number of Residues | 9 |
| Details | binding site for residue DG B 412 |
| Chain | Residue |
| A | DA407 |
| A | DC408 |
| B | GLY13 |
| B | VAL37 |
| B | MET40 |
| B | O0Q402 |
| B | DG410 |
| B | DA411 |
| B | DU413 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 403 |
| Chain | Residue |
| A | DG424 |
| C | DG404 |
| C | DC412 |
| C | DC413 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue DG C 404 |
| Chain | Residue |
| C | O0Q402 |
| C | DG403 |
| C | DU405 |
| C | DA411 |
| C | DC412 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue DA C 406 |
| Chain | Residue |
| C | DC407 |
| D | DG406 |
| D | DG413 |
| D | DU414 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue DC C 407 |
| Chain | Residue |
| C | LEU232 |
| C | DA406 |
| D | DC407 |
| D | DG411 |
| D | DG413 |
| site_id | AF8 |
| Number of Residues | 8 |
| Details | binding site for residue DC C 408 |
| Chain | Residue |
| C | MET14 |
| C | ALA233 |
| C | SER234 |
| C | TYR236 |
| C | O0Q401 |
| C | DC409 |
| D | O0Q401 |
| D | DU414 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue DC C 409 |
| Chain | Residue |
| C | DC408 |
| C | DU410 |
| D | DG406 |
| D | DU414 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue DA C 411 |
| Chain | Residue |
| C | DG404 |
| C | DU405 |
| C | DU410 |
| C | DC412 |
| D | DA405 |
| D | DG406 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue DC C 412 |
| Chain | Residue |
| C | DG403 |
| C | DG404 |
| C | DA411 |
| C | DC413 |
| D | LYS207 |
| D | DG406 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue DC C 413 |
| Chain | Residue |
| A | DG424 |
| C | DG403 |
| C | DC412 |
| C | DG414 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 414 |
| Chain | Residue |
| A | DG423 |
| A | DG424 |
| C | DC413 |
| C | DA415 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue DA C 415 |
| Chain | Residue |
| A | DC422 |
| A | DG423 |
| A | DG424 |
| C | DG414 |
| C | DG416 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 416 |
| Chain | Residue |
| A | DA421 |
| A | DC422 |
| C | DA415 |
| C | DG417 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 417 |
| Chain | Residue |
| A | DC420 |
| A | DA421 |
| C | DG416 |
| C | DG418 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 418 |
| Chain | Residue |
| A | DG419 |
| A | DC420 |
| C | DG417 |
| C | DC419 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue DC C 419 |
| Chain | Residue |
| A | DG418 |
| A | DG419 |
| C | DG418 |
| C | DA420 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue DA C 420 |
| Chain | Residue |
| A | DG417 |
| A | DG418 |
| A | DG419 |
| C | DC419 |
| C | DC421 |
| C | HOH503 |
| C | HOH504 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue DC C 421 |
| Chain | Residue |
| A | DA416 |
| A | DG417 |
| C | DA420 |
| C | DG422 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue DG C 422 |
| Chain | Residue |
| A | DG415 |
| A | DA416 |
| C | DC421 |
| C | DG423 |
| site_id | AH4 |
| Number of Residues | 6 |
| Details | binding site for residue DG C 423 |
| Chain | Residue |
| A | DG403 |
| A | DC414 |
| A | DG415 |
| A | DA416 |
| C | DG422 |
| C | DA424 |
| site_id | AH5 |
| Number of Residues | 1 |
| Details | binding site for residue DA C 424 |
| Chain | Residue |
| C | DG423 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue DA D 403 |
| Chain | Residue |
| C | O0Q402 |
| C | DU405 |
| D | O0Q402 |
| D | DU404 |
| D | DA405 |
| D | HOH523 |
| site_id | AH7 |
| Number of Residues | 7 |
| Details | binding site for residue DA D 405 |
| Chain | Residue |
| C | DU405 |
| C | DU410 |
| C | DA411 |
| D | LYS84 |
| D | DA403 |
| D | DU404 |
| D | DG406 |
| site_id | AH8 |
| Number of Residues | 7 |
| Details | binding site for residue DG D 406 |
| Chain | Residue |
| C | DA406 |
| C | DC409 |
| C | DU410 |
| C | DA411 |
| C | DC412 |
| D | DA405 |
| D | DU414 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue DC D 407 |
| Chain | Residue |
| C | DC407 |
| D | DC408 |
| D | DU410 |
| D | DG411 |
| site_id | AI1 |
| Number of Residues | 6 |
| Details | binding site for residue DC D 408 |
| Chain | Residue |
| C | GLY269 |
| C | HIS270 |
| D | LYS38 |
| D | DC407 |
| D | DC409 |
| D | DU410 |
| site_id | AI2 |
| Number of Residues | 2 |
| Details | binding site for residue DC D 409 |
| Chain | Residue |
| D | DC408 |
| D | DU410 |
| site_id | AI3 |
| Number of Residues | 4 |
| Details | binding site for residue DU D 410 |
| Chain | Residue |
| D | DC407 |
| D | DC408 |
| D | DC409 |
| D | DG411 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue DG D 411 |
| Chain | Residue |
| C | DC407 |
| D | DC407 |
| D | DU410 |
| D | DA412 |
| D | DG413 |
| site_id | AI5 |
| Number of Residues | 9 |
| Details | binding site for residue DA D 412 |
| Chain | Residue |
| D | VAL36 |
| D | TYR67 |
| D | ALA80 |
| D | GLY81 |
| D | PHE82 |
| D | ILE105 |
| D | GLU108 |
| D | DG411 |
| D | DG413 |
| site_id | AI6 |
| Number of Residues | 10 |
| Details | binding site for residue DG D 413 |
| Chain | Residue |
| C | DA406 |
| C | DC407 |
| D | GLY13 |
| D | VAL37 |
| D | MET40 |
| D | O0Q401 |
| D | DG411 |
| D | DA412 |
| D | DU414 |
| D | HOH521 |
| site_id | AI7 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q A 401 and DU A 411 |
| Chain | Residue |
| A | MET14 |
| A | DG406 |
| A | DC409 |
| A | DC410 |
| A | DA412 |
| B | LEU232 |
| B | O0Q401 |
| B | DU404 |
| B | DA405 |
| site_id | AI8 |
| Number of Residues | 6 |
| Details | binding site for Di-nucleotide O0Q A 402 and DU A 405 |
| Chain | Residue |
| A | LYS38 |
| A | DG404 |
| A | DA412 |
| B | O0Q401 |
| B | DA403 |
| B | DA405 |
| site_id | AI9 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q B 401 and DU B 404 |
| Chain | Residue |
| A | ASN39 |
| A | O0Q401 |
| A | O0Q402 |
| A | DU411 |
| B | LEU231 |
| B | LEU232 |
| B | O0Q402 |
| B | DA403 |
| B | DA405 |
| site_id | AJ1 |
| Number of Residues | 11 |
| Details | binding site for Di-nucleotide O0Q B 402 and DU B 413 |
| Chain | Residue |
| A | DG406 |
| A | DA407 |
| A | DC409 |
| A | DC410 |
| B | GLY13 |
| B | MET14 |
| B | MET40 |
| B | LYS44 |
| B | ALA233 |
| B | DU404 |
| B | DG412 |
| site_id | AJ2 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide O0Q C 401 and DU C 410 |
| Chain | Residue |
| C | MET14 |
| C | DC408 |
| C | DC409 |
| C | DA411 |
| D | LEU232 |
| D | O0Q402 |
| D | DU404 |
| D | DA405 |
| D | DG406 |
| site_id | AJ3 |
| Number of Residues | 7 |
| Details | binding site for Di-nucleotide O0Q C 402 and DU C 405 |
| Chain | Residue |
| C | VAL37 |
| C | DG404 |
| C | DA411 |
| C | HOH501 |
| D | O0Q402 |
| D | DA403 |
| D | DA405 |
| site_id | AJ4 |
| Number of Residues | 11 |
| Details | binding site for Di-nucleotide O0Q D 401 and DU D 414 |
| Chain | Residue |
| C | DA406 |
| C | DC408 |
| C | DC409 |
| D | GLY13 |
| D | MET14 |
| D | LYS44 |
| D | ALA233 |
| D | O0Q402 |
| D | DU404 |
| D | DG406 |
| D | DG413 |
| site_id | AJ5 |
| Number of Residues | 12 |
| Details | binding site for Di-nucleotide O0Q D 402 and DU D 404 |
| Chain | Residue |
| C | VAL37 |
| C | ASN39 |
| C | MET40 |
| C | O0Q401 |
| C | O0Q402 |
| C | DU410 |
| D | ASN230 |
| D | LEU231 |
| D | LEU232 |
| D | O0Q401 |
| D | DA403 |
| D | DA405 |
