7BIX
Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (C2 form)
Summary for 7BIX
| Entry DOI | 10.2210/pdb7bix/pdb |
| Descriptor | Uridylate kinase, URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, ... (4 entities in total) |
| Functional Keywords | ump kinase, transferase |
| Biological source | Mycobacterium tuberculosis H37Rv |
| Total number of polymer chains | 12 |
| Total formula weight | 361648.85 |
| Authors | Labesse, G.,Walter, P.,Haouz, A.,Mechaly, A.E.,Munier-Lehmann, H. (deposition date: 2021-01-13, release date: 2022-03-02, Last modification date: 2024-01-31) |
| Primary citation | Walter, P.,Mechaly, A.,Bous, J.,Haouz, A.,England, P.,Lai-Kee-Him, J.,Ancelin, A.,Hoos, S.,Baron, B.,Trapani, S.,Bron, P.,Labesse, G.,Munier-Lehmann, H. Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J., 289:4869-4887, 2022 Cited by PubMed: 35152545DOI: 10.1111/febs.16393 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
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