Author results

2QHR
  • Download 2qhr
  • View 2qhr
Molmil generated image of 2qhr
CRYSTAL STRUCTURE OF THE 13F6-1-2 FAB FRAGMENT BOUND TO ITS EBOLA VIRUS GLYCOPROTEIN PEPTIDE EPITOPE.
Descriptor:13F6-1-2 Fab fragment heavy chain, 13F6-1-2 Fab fragment V lambda x light chain, Envelope glycoprotein peptide
Authors:Lee, J.E., Kuehne, A., Abelson, D.M., Fusco, M.L., Hart, M.K., Saphire, E.O.
Deposit date:2007-07-02
Release date:2008-01-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain.
J.Mol.Biol., 375, 2008
3CSY
  • Download 3csy
  • View 3csy
Molmil generated image of 3csy
CRYSTAL STRUCTURE OF THE TRIMERIC PREFUSION EBOLA VIRUS GLYCOPROTEIN IN COMPLEX WITH A NEUTRALIZING ANTIBODY FROM A HUMAN SURVIVOR
Descriptor:Fab KZ52 heavy chain, Fab KZ52 light chain, Envelope glycoprotein GP1, ...
Authors:Lee, J.E., Fusco, M.L., Hessell, A.J., Oswald, W.B., Burton, D.R., Saphire, E.O.
Deposit date:2008-04-10
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor.
Nature, 454, 2008
3INU
  • Download 3inu
  • View 3inu
Molmil generated image of 3inu
CRYSTAL STRUCTURE OF AN UNBOUND KZ52 NEUTRALIZING ANTI-EBOLAVIRUS ANTIBODY.
Descriptor:KZ52 antibody fragment heavy chain, KZ52 antibody fragment light chain, SULFATE ION, ...
Authors:Lee, J.E., Fusco, M.L., Abelson, D.M., Hessell, A.J., Burton, D.R., Saphire, E.O.
Deposit date:2009-08-12
Release date:2009-10-27
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein.
Acta Crystallogr.,Sect.D, 65, 2009
5HJ3
  • Download 5hj3
  • View 5hj3
Molmil generated image of 5hj3
CRYSTAL STRUCTURE OF HOST-PRIMED EBOLA VIRUS GP, GPCL.
Descriptor:Envelope glycoprotein, KZ52 Antibody Fragment, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bornholdt, Z.A., Fusco, M.L., Saphire, E.O.
Deposit date:2016-01-12
Release date:2016-03-09
Last modified:2016-05-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
Mbio, 7, 2016
5KEL
  • Download 5kel
  • View 5kel
Molmil generated image of 5kel
EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEM
  • Download 5kem
  • View 5kem
Molmil generated image of 5kem
EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91
Descriptor:BDBV91 variable Fab domain light chain, BDBV91 variable Fab domain heavy chain, c13C6 variable Fab domain heavy chain, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEN
  • Download 5ken
  • View 5ken
Molmil generated image of 5ken
EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5UQY
  • Download 5uqy
  • View 5uqy
Molmil generated image of 5uqy
CRYSTAL STRUCTURE OF MARBURG VIRUS GP IN COMPLEX WITH THE HUMAN SURVIVOR ANTIBODY MR78
Descriptor:ENVELOPE GLYCOPROTEIN GP1, ENVELOPE GLYCOPROTEIN GP2, MR78 Fab light chain, ...
Authors:Hashiguchi, T., Fusco, M.L., Hastie, K.M., Bomholdt, Z.A., Lee, J.E., Flyak, A.I., Matsuoka, R., Kohda, D., Yanagi, Y., Hammel, M., Crowe, J.E., Saphire, E.O.
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for Marburg virus neutralization by a cross-reactive human antibody.
Cell, 160, 2015
6BP2
  • Download 6bp2
  • View 6bp2
Molmil generated image of 6bp2
THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN
Descriptor:Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ...
Authors:King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O.
Deposit date:2017-11-21
Release date:2018-01-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
6EA5
  • Download 6ea5
  • View 6ea5
Molmil generated image of 6ea5
STRUCTURE OF BDBV GPCL IN COMPLEX WITH THE PAN-EBOLAVIRUS MAB ADI-15878
Descriptor:Envelope glycoprotein, Glycoprotein, ADI-15878 Fab Heavy Chain, ...
Authors:King, L.B., West, B.R., Moyer, C.L., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O.
Deposit date:2018-08-02
Release date:2018-09-19
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (4.75 Å)
Cite:Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
MBio, 9, 2018
6EA7
  • Download 6ea7
  • View 6ea7
Molmil generated image of 6ea7
STRUCTURE OF EBOV GPCL IN COMPLEX WITH THE PAN-EBOLAVIRUS MAB ADI-15878
Descriptor:Envelope glycoprotein, ADI-15878 Fab Heavy Chain, ADI-15878 Fab Light Chain, ...
Authors:West, B.R., Moyer, C.L., King, L.B., Fusco, M.L., Milligan, J.C., Hui, S., Saphire, E.O.
Deposit date:2018-08-02
Release date:2018-09-19
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (4.25 Å)
Cite:Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope.
MBio, 9, 2018
6MAM
  • Download 6mam
  • View 6mam
Molmil generated image of 6mam
CLEAVED EBOLA GP IN COMPLEX WITH A BROADLY NEUTRALIZING HUMAN ANTIBODY, ADI-15946
Descriptor:ADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ...
Authors:West, B.R., Moyer, C.L., Fusco, M.L., Saphire, E.O.
Deposit date:2018-08-28
Release date:2019-03-20
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Nat. Struct. Mol. Biol., 26, 2019
2Y6S
  • Download 2y6s
  • View 2y6s
Molmil generated image of 2y6s
STRUCTURE OF AN EBOLAVIRUS-PROTECTIVE ANTIBODY IN COMPLEX WITH ITS MUCIN-DOMAIN LINEAR EPITOPE
Descriptor:LIGHT CHAIN, HEAVY CHAIN, ENVELOPE GLYCOPROTEIN
Authors:Olal, D.O., Kuehne, A., Lee, J.E., Bale, S., Dye, J.M., Saphire, E.O.
Deposit date:2011-01-25
Release date:2012-01-11
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope.
J.Virol., 86, 2012
3S88
  • Download 3s88
  • View 3s88
Molmil generated image of 3s88
CRYSTAL STRUCTURE OF SUDAN EBOLAVIRUS GLYCOPROTEIN (STRAIN GULU) BOUND TO 16F6
Descriptor:16F6 - Heavy chain, Envelope glycoprotein, 16F6 - Light chain, ...
Authors:Saphire, E.O., Dias, J.M., Bale, S.
Deposit date:2011-05-27
Release date:2011-12-07
Last modified:2011-12-21
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:A shared structural solution for neutralizing ebolaviruses.
Nat.Struct.Mol.Biol., 18, 2011
3VE0
  • Download 3ve0
  • View 3ve0
Molmil generated image of 3ve0
CRYSTAL STRUCTURE OF SUDAN EBOLAVIRUS GLYCOPROTEIN (STRAIN BONIFACE) BOUND TO 16F6
Descriptor:Envelope glycoprotein, 16F6 Antibody chain A, 16F6 Antibody chain B, ...
Authors:Saphire, E.O., Bale, S., Dias, J.M.
Deposit date:2012-01-06
Release date:2012-04-18
Last modified:2012-05-30
Method:X-RAY DIFFRACTION (3.353 Å)
Cite:Structural basis for differential neutralization of ebolaviruses.
Viruses, 4, 2012