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4LRS
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BU of 4lrs by Molmil
Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, CHLORIDE ION, ...
Authors:Fischer, B, Branlant, G, Talfournier, F, Gruez, A.
Deposit date:2013-07-20
Release date:2013-09-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
To be Published
5HJQ
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BU of 5hjq by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, LD10117p
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
5HJN
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BU of 5hjn by Molmil
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster
Descriptor: LD10117p, SULFATE ION
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2016-01-13
Release date:2016-09-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function.
Nat.Struct.Mol.Biol., 23, 2016
4LRT
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BU of 4lrt by Molmil
Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Descriptor: 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, COENZYME A, ...
Authors:Fischer, B, Branlant, G, Talfournier, F, Gruez, A.
Deposit date:2013-07-20
Release date:2013-09-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
To be Published
8BE4
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BU of 8be4 by Molmil
Crystal structure of SOS1-KRasG12V-Nanobody14
Descriptor: Isoform 2B of GTPase KRas, Nanobody14, Son of sevenless homolog 1
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-11-01
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
8BE5
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BU of 8be5 by Molmil
Crystal structure of SOS1-KRasG12V-Nanobody22-Nanobody75
Descriptor: Isoform 2B of GTPase KRas, Nanobody22, Nanobody75, ...
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-11-01
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
8BE2
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BU of 8be2 by Molmil
Crystal structure of SOS1-Nanobody77
Descriptor: Nanobody 77, SULFATE ION, Son of sevenless homolog 1
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-11-01
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (1.897935 Å)
Cite:Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
8BE3
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BU of 8be3 by Molmil
Crystal structure of KRasG12V-Nanobody84
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ...
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-11-01
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Allosteric nanobodies to study the interactions between SOS1 and RAS.
Nat Commun, 15, 2024
8BE7
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BU of 8be7 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic3
Descriptor: GTPase HRas, SOS1-HRas-peptidomimetic3, Son of sevenless homolog 1
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE6
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BU of 8be6 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic2
Descriptor: GTPase HRas, SOS1-HRas-peptidomimetic2, Son of sevenless homolog 1
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.89880252 Å)
Cite:Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE8
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BU of 8be8 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic4
Descriptor: FORMIC ACID, GTPase HRas, SOS1-HRas-peptidomimetic4, ...
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BE9
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BU of 8be9 by Molmil
Crystal structure of SOS1-HRas-peptidomimetic5
Descriptor: CHLORIDE ION, FORMIC ACID, GTPase HRas, ...
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
8BEA
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BU of 8bea by Molmil
Crystal structure of SOS1-HRas-peptidomimetic10
Descriptor: GTPase HRas, SOS1-HRas-peptidomimetic10, Son of sevenless homolog 1
Authors:Fischer, B, Wohlkonig, A, Steyaert, J.
Deposit date:2022-10-21
Release date:2023-04-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.
Angew.Chem.Int.Ed.Engl., 62, 2023
6R82
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BU of 6r82 by Molmil
Crystal structure of the TLDc domain of Skywalker/TBC1D24 from Drosophila melanogaster
Descriptor: GTPase-activating protein skywalker
Authors:Fischer, B, Paesmans, J, Versees, W.
Deposit date:2019-03-30
Release date:2019-07-17
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.046 Å)
Cite:TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model.
Brain, 142, 2019
6XVI
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BU of 6xvi by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_A12
Descriptor: Outer membrane protein,Outer membrane protein,Mb-Nb207-c7HopQ_A12
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-22
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XUX
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BU of 6xux by Molmil
Crystal structure of Megabody Mb-Nb207-cYgjK_NO
Descriptor: CALCIUM ION, Nanobody,Glucosidase YgjK,Glucosidase YgjK,Nanobody
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.90000641 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6XV8
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BU of 6xv8 by Molmil
Crystal structure of Megabody Mb-Nb207-c7HopQ_G10
Descriptor: Outer membrane protein
Authors:Steyaert, J, Uchanski, T, Fischer, B.
Deposit date:2020-01-21
Release date:2021-01-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
6QD6
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BU of 6qd6 by Molmil
Molecular scaffolds expand the nanobody toolkit for cryo-EM applications: crystal structure of Mb-cHopQ-Nb207
Descriptor: CHLORIDE ION, Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207,Outer membrane protein,Mb-cHopQ-Nb207
Authors:Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkonig, A, Zogg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
Deposit date:2018-12-31
Release date:2019-12-18
Last modified:2021-01-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Nat.Methods, 18, 2021
6QFA
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BU of 6qfa by Molmil
CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ...
Authors:Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J.
Deposit date:2019-01-09
Release date:2021-08-04
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Nat.Methods, 18, 2021
7QLF
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BU of 7qlf by Molmil
Conformational ensemble of solnatide in solution
Descriptor: Tumor necrosis factor
Authors:Macias, M.J, Martin-Malpartida, P.
Deposit date:2021-12-20
Release date:2022-06-08
Method:SOLUTION NMR
Cite:Conformational ensemble of the TNF-derived peptide solnatide in solution.
Comput Struct Biotechnol J, 20, 2022
5MW6
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BU of 5mw6 by Molmil
Crystal structure of the BCL6 BTB-domain with compound 1
Descriptor: 5-chloranyl-~{N}-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine, B-cell lymphoma 6 protein
Authors:Davies, D.R, Kessler, D.
Deposit date:2017-01-18
Release date:2017-10-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
5MWD
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BU of 5mwd by Molmil
Crystal structure of the BCL6 BTB-domain with compound 2
Descriptor: 5-[[5-chloranyl-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein
Authors:Bader, G, Flotzinger, G, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2017-01-18
Release date:2017-10-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017
5MW2
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BU of 5mw2 by Molmil
CRYSTAL STRUCTURE OF BCL-6 BTB-domain with BI-3802
Descriptor: 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide, B-cell lymphoma 6 protein
Authors:Bader, G, Flotzinger, G, Weiss-Puxbaum, A, Zoephel, A.
Deposit date:2017-01-18
Release date:2017-10-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Cell Rep, 20, 2017

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