8BE6

Crystal structure of SOS1-HRas-peptidomimetic2

Summary for 8BE6

• Entry DOI: 10.2210/pdb8be6/pdb
• Descriptor: GTPase HRas, Son of sevenless homolog 1, SOS1-HRas-peptidomimetic2, ... (4 entities in total)
• Functional Keywords: complex, stabilizer, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 81247.35

Authors

Fischer, B.,Wohlkonig, A.,Steyaert, J. (deposition date: 2022-10-21, release date: 2023-04-26, Last modification date: 2024-02-07)

• Primary citation: Van Holsbeeck, K.,Fischer, B.,Gonzalez, S.,Gadais, C.,Versees, W.,Martins, J.C.,Martin, C.,Wohlkonig, A.,Steyaert, J.,Ballet, S.; Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS.; Angew.Chem.Int.Ed.Engl., 62:e202219095-e202219095, 2023; PubMed: 37067463; DOI: 10.1002/anie.202219095

Experimental method

X-RAY DIFFRACTION (2.89880249261 Å)