5MWD

Crystal structure of the BCL6 BTB-domain with compound 2

Summary for 5MWD

• Entry DOI: 10.2210/pdb5mwd/pdb
• Descriptor: B-cell lymphoma 6 protein, 5-[[5-chloranyl-2-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one (3 entities in total)
• Functional Keywords: transcription, inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14857.57

Authors

Bader, G.,Flotzinger, G.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2017-01-18, release date: 2017-10-04, Last modification date: 2019-10-16)

• Primary citation: Kerres, N.,Steurer, S.,Schlager, S.,Bader, G.,Berger, H.,Caligiuri, M.,Dank, C.,Engen, J.R.,Ettmayer, P.,Fischerauer, B.,Flotzinger, G.,Gerlach, D.,Gerstberger, T.,Gmaschitz, T.,Greb, P.,Han, B.,Heyes, E.,Iacob, R.E.,Kessler, D.,Kolle, H.,Lamarre, L.,Lancia, D.R.,Lucas, S.,Mayer, M.,Mayr, K.,Mischerikow, N.,Muck, K.,Peinsipp, C.,Petermann, O.,Reiser, U.,Rudolph, D.,Rumpel, K.,Salomon, C.,Scharn, D.,Schnitzer, R.,Schrenk, A.,Schweifer, N.,Thompson, D.,Traxler, E.,Varecka, R.,Voss, T.,Weiss-Puxbaum, A.,Winkler, S.,Zheng, X.,Zoephel, A.,Kraut, N.,McConnell, D.,Pearson, M.,Koegl, M.; Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.; Cell Rep, 20:2860-2875, 2017; PubMed: 28930682; DOI: 10.1016/j.celrep.2017.08.081

Experimental method

X-RAY DIFFRACTION (1.85 Å)