5MW2
CRYSTAL STRUCTURE OF BCL-6 BTB-domain with BI-3802
Summary for 5MW2
Entry DOI | 10.2210/pdb5mw2/pdb |
Descriptor | B-cell lymphoma 6 protein, 2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide (3 entities in total) |
Functional Keywords | transcription, inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P41182 |
Total number of polymer chains | 1 |
Total formula weight | 14987.75 |
Authors | Bader, G.,Flotzinger, G.,Weiss-Puxbaum, A.,Zoephel, A. (deposition date: 2017-01-18, release date: 2017-10-04, Last modification date: 2024-05-08) |
Primary citation | Kerres, N.,Steurer, S.,Schlager, S.,Bader, G.,Berger, H.,Caligiuri, M.,Dank, C.,Engen, J.R.,Ettmayer, P.,Fischerauer, B.,Flotzinger, G.,Gerlach, D.,Gerstberger, T.,Gmaschitz, T.,Greb, P.,Han, B.,Heyes, E.,Iacob, R.E.,Kessler, D.,Kolle, H.,Lamarre, L.,Lancia, D.R.,Lucas, S.,Mayer, M.,Mayr, K.,Mischerikow, N.,Muck, K.,Peinsipp, C.,Petermann, O.,Reiser, U.,Rudolph, D.,Rumpel, K.,Salomon, C.,Scharn, D.,Schnitzer, R.,Schrenk, A.,Schweifer, N.,Thompson, D.,Traxler, E.,Varecka, R.,Voss, T.,Weiss-Puxbaum, A.,Winkler, S.,Zheng, X.,Zoephel, A.,Kraut, N.,McConnell, D.,Pearson, M.,Koegl, M. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep, 20:2860-2875, 2017 Cited by PubMed: 28930682DOI: 10.1016/j.celrep.2017.08.081 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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