5HJQ
Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate
Summary for 5HJQ
Entry DOI | 10.2210/pdb5hjq/pdb |
Descriptor | LD10117p, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE (3 entities in total) |
Functional Keywords | tbc, rabgap, signaling protein |
Biological source | Drosophila melanogaster (Fruit fly) |
Total number of polymer chains | 1 |
Total formula weight | 43516.89 |
Authors | Fischer, B.,Paesmans, J.,Versees, W. (deposition date: 2016-01-13, release date: 2016-09-21, Last modification date: 2024-01-10) |
Primary citation | Fischer, B.,Luthy, K.,Paesmans, J.,De Koninck, C.,Maes, I.,Swerts, J.,Kuenen, S.,Uytterhoeven, V.,Verstreken, P.,Versees, W. Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat.Struct.Mol.Biol., 23:965-973, 2016 Cited by PubMed: 27669036DOI: 10.1038/nsmb.3297 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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