5HJQ

Crystal structure of the TBC domain of Skywalker/TBC1D24 from Drosophila melanogaster in complex with inositol(1,4,5)triphosphate

Summary for 5HJQ

Entry DOI	10.2210/pdb5hjq/pdb
Descriptor	LD10117p, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE (3 entities in total)
Functional Keywords	tbc, rabgap, signaling protein
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	1
Total formula weight	43516.89
Authors	Fischer, B.,Paesmans, J.,Versees, W. (deposition date: 2016-01-13, release date: 2016-09-21, Last modification date: 2024-01-10)
Primary citation	Fischer, B.,Luthy, K.,Paesmans, J.,De Koninck, C.,Maes, I.,Swerts, J.,Kuenen, S.,Uytterhoeven, V.,Verstreken, P.,Versees, W. Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function. Nat.Struct.Mol.Biol., 23:965-973, 2016 Cited by PubMed: 27669036 DOI: 10.1038/nsmb.3297 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation