Author results

2F57
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 5
Descriptor:Serine/threonine-protein kinase PAK 7, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
Authors:Eswaran, J., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Bray, J., Das, S., Savitsky, P., Smee, C., Burgess, N., Fedorov, O., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Sundstrom, M., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-25
Release date:2005-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs.
Structure, 15, 2007
2VUW
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STRUCTURE OF HUMAN HASPIN KINASE DOMAIN
Descriptor:SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Eswaran, J., Murray, J.W., Filippakopoulos, P., Soundararajan, M., Pike, A.C.W., von Delft, F., Picaud, S., Keates, T., King, O., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Fedorov, O., Burgess-Brown, N., Bray, J., Knapp, S.
Deposit date:2008-05-30
Release date:2008-09-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Functional Characterization of the Atypical Human Kinase Haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2BIJ
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE)
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION
Authors:Barr, A.J., Debreczeni, J.E., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S., von Delft, F.
Deposit date:2005-01-21
Release date:2005-03-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2BV5
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-06-22
Release date:2005-07-14
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2C30
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 6
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 6, PHOSPHATE ION, CHLORIDE ION
Authors:Filippakopoulos, P., Berridge, G., Bray, J., Burgess, N., Colebrook, S., Das, S., Eswaran, J., Gileadi, O., Papagrigoriou, E., Savitsky, P., Smee, C., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
Deposit date:2005-10-02
Release date:2006-02-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
2C7S
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CRYSTAL STRUCTURE OF HUMAN PROTEIN TYROSINE PHOSPHATASE KAPPA AT 1.95A RESOLUTION
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE KAPPA, ACETATE ION
Authors:Debreczeni, J.E., Ugochukwu, E., Eswaran, J., Barr, A., Das, S., Burgess, N., Gileadi, O., Longman, E., von Delft, F., Knapp, S., Sundstron, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-11-28
Release date:2007-01-02
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2CDZ
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH CGP74514A
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 4, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE, SULFATE ION, ...
Authors:Debreczeni, J.E., Ugochukwu, E., Eswaran, J., Filippakopoulos, P., Das, S., Fedorov, O., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
Deposit date:2006-01-31
Release date:2006-02-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
3IQ7
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CRYSTAL STRUCTURE OF HUMAN HASPIN IN COMPLEX WITH 5-IODOTUBERCIDIN
Descriptor:Serine/threonine-protein kinase haspin, PHOSPHATE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ...
Authors:Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-08-19
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and functional characterization of the atypical human kinase haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2A3K
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE, PTPN7 (HEPTP, HEMATOPOIETIC PROTEIN TYROSINE PHOSPHATASE)
Descriptor:protein tyrosine phosphatase, non-receptor type 7, isoform 1, ...
Authors:Barr, A., Turnbull, A.P., Das, S., Eswaran, J., Debreczeni, J.E., Longmann, E., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-06-24
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2A8B
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN TYROSINE PHOSPHATASE RECEPTOR, TYPE R
Descriptor:Receptor-type tyrosine-protein phosphatase R, CHLORIDE ION
Authors:Ugochukwu, E., Eswaran, J., Barr, A., Longman, E., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-07-07
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem.J., 395, 2006
2BVA
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
Descriptor:P21-ACTIVATED KINASE 4
Authors:Debreczeni, J.E., Bunkoczi, G., Eswaran, J., Filippakopoulos, P., Das, S., Fedorov, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S.
Deposit date:2005-06-23
Release date:2005-07-14
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007
3DLZ
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CRYSTAL STRUCTURE OF HUMAN HASPIN IN COMPLEX WITH AMP
Descriptor:Serine/threonine-protein kinase haspin, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Murray, J.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-06-30
Release date:2008-07-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and functional characterization of the atypical human kinase haspin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2C47
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STRUCTURE OF CASEIN KINASE 1 GAMMA 2
Descriptor:CASEIN KINASE 1 GAMMA 2 ISOFORM, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, MAGNESIUM ION
Authors:Bunkoczi, G., Rellos, P., Das, S., Ugochukwu, E., Fedorov, O., Sobott, F., Eswaran, J., Amos, A., Ball, L., von Delft, F., Bullock, A., Debreczeni, J., Turnbull, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-10-16
Release date:2005-11-07
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of Casein Kinase 1 Gamma 2
To be Published
2RF0
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CRYSTAL STRUCTURE OF HUMAN MIXED LINEAGE KINASE MAP3K10 SH3 DOMAIN
Descriptor:Mitogen-activated protein kinase kinase kinase 10, 1,2-ETHANEDIOL
Authors:Ugochukwu, E., Eswaran, J., Elkins, J., Keates, T., Pike, A.C.W., Berridge, G., Savitsky, P., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-10-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human Mixed lineage kinase MAP3K10 SH3 domain.
To be Published
2BZL
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE N14 AT 1. 65 A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 14, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A., Eswaran, J., Das, S., Burgess, N., Longman, E., Fedorov, O., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Knapp, S.
Deposit date:2005-08-18
Release date:2005-09-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of Human Protein Tyrosine Phosphatase 14 (Ptpn14) at 1.65-A Resolution.
Proteins, 63, 2006
2J0I
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 4, 1,2-ETHANEDIOL
Authors:Debreczeni, J.E., Eswaran, J., Ugochukwu, E., Papagrigoriou, E., Turnbull, A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Knapp, S.
Deposit date:2006-08-03
Release date:2006-08-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human P21-Activated Kinase 4
To be Published
2JII
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STRUCTURE OF VACCINIA RELATED KINASE 3
Descriptor:SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL
Authors:Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.
Structure, 17, 2009
2ODB
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THE CRYSTAL STRUCTURE OF HUMAN CDC42 IN COMPLEX WITH THE CRIB DOMAIN OF HUMAN P21-ACTIVATED KINASE 6 (PAK6)
Descriptor:Human Cell Division Cycle 42 (CDC42), Serine/threonine-protein kinase PAK 6, CHLORIDE ION, ...
Authors:Ugochukwu, E., Yang, X., Elkins, J., Soundararajan, M., Pike, A.C.W., Eswaran, J., Burgess, N., Debreczeni, J.E., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Gileadi, O., von Delft, F., Knapp, S., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-12-22
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)
To be Published
2Q0N
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STRUCTURE OF HUMAN P21 ACTIVATING KINASE 4 (PAK4) IN COMPLEX WITH A CONSENSUS PEPTIDE
Descriptor:Serine/threonine-protein kinase PAK 4, Synthetic peptide, SULFATE ION, ...
Authors:Filippakopoulos, P., Eswaran, J., Turnbull, A., Papagrigoriou, E., Pike, A.W., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-05-22
Release date:2007-06-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide.
To be Published
2V62
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STRUCTURE OF VACCINIA-RELATED KINASE 2
Descriptor:SERINE/THREONINE-PROTEIN KINASE VRK2, MAGNESIUM ION, SUCCINIC ACID, ...
Authors:Bunkoczi, G., Eswaran, J., Cooper, C., Fedorov, O., Keates, T., Rellos, P., Salah, E., Savitsky, P., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2007-07-13
Release date:2007-08-21
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the Pseudokinase Vrk3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site.
Structure, 17, 2009
3F2N
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CRYSTAL STRUCTURE OF HUMAN HASPIN WITH AN IMIDAZO-PYRIDAZINE LIGAND
Descriptor:Serine/threonine-protein kinase haspin, (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol, PHOSPHATE ION, ...
Authors:Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Yue, W.W., Murray, J.W., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-10-30
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand
To be Published
3FMD
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CRYSTAL STRUCTURE OF HUMAN HASPIN WITH AN ISOQUINOLINE LIGAND
Descriptor:Serine/threonine-protein kinase haspin, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, NICKEL (II) ION, ...
Authors:Filippakopoulos, P., Eswaran, J., Keates, T., Burgess-Brown, N., Fedorov, O., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-12-21
Release date:2008-12-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human Haspin with an Isoquinoline ligand
To be Published
3NR9
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STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)
Descriptor:Dual specificity protein kinase CLK2, (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one
Authors:Chaikuad, A., Savitsky, P., Krojer, T., Muniz, J.R.C., Filippakopoulos, P., Rellos, P., Keates, T., Fedorov, O., Pike, A.C.W., Eswaran, J., Berridge, G., Phillips, C., Zhang, Y., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-06-30
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of human CDC2-like kinase 2 (CLK2)
To be Published
3P1A
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STRUCTURE OF HUMAN MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE MYT1 (PKMYT1)
Descriptor:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE
Authors:Chaikuad, A., Eswaran, J., Fedorov, O., Cooper, C.D.O., Kroeler, T., Vollmar, M., Krojer, T., Berridge, G., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
To be Published
4O38
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CRYSTAL STRUCTURE OF THE HUMAN CYCLIN G ASSOCIATED KINASE (GAK)
Descriptor:Cyclin-G-associated kinase, SUCCINIC ACID, GLYCEROL
Authors:Zhang, R., Hatzos-Skintges, C., Weger, A., Chaikuad, A., Eswaran, J., Fedorov, O., King, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structural Genomics Consortium (SGC)
Deposit date:2013-12-18
Release date:2014-01-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Crystal structure of the human cyclin G associated kinase (GAK)
To be Published
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