3FMD
Crystal Structure of Human Haspin with an Isoquinoline ligand
Summary for 3FMD
Entry DOI | 10.2210/pdb3fmd/pdb |
Descriptor | Serine/threonine-protein kinase haspin, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, NICKEL (II) ION, ... (5 entities in total) |
Functional Keywords | haspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics consortium, sgc |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q8TF76 |
Total number of polymer chains | 1 |
Total formula weight | 41278.61 |
Authors | Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-12-21, release date: 2008-12-30, Last modification date: 2023-09-06) |
Primary citation | Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S. Crystal Structure of Human Haspin with an Isoquinoline ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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