3FMD

Crystal Structure of Human Haspin with an Isoquinoline ligand

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IQB A 1

Chain	Residue
A	HOH73
A	ASP611
A	GLU613
A	HIS651
A	GLY653
A	LEU656
A	ILE686
A	GLN718
A	HOH287
A	HOH289
A	ILE490
A	GLY491
A	VAL498
A	ALA509
A	GLY608
A	GLY609

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI A 799

Chain	Residue
A	HOH380
A	HOH381
A	HOH406
A	HOH408
A	HIS477
A	HIS563

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 800

Chain	Residue
A	HOH47
A	HOH207
A	THR553
A	GLY555
A	ALA634
A	SER635
A	TYR667

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK

Chain	Residue	Details
A	ILE490-LYS511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	314
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3DLZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---