2VUW

Structure of human haspin kinase domain

Summary for 2VUW

Entry DOI	10.2210/pdb2vuw/pdb
Descriptor	SERINE/THREONINE-PROTEIN KINASE HASPIN, IODIDE ION, (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, ... (7 entities in total)
Functional Keywords	cell cycle, transferase, casp8, nucleotide binding
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q8TF76
Total number of polymer chains	1
Total formula weight	39389.05
Authors	Eswaran, J.,Murray, J.W.,Filippakopoulos, P.,Soundararajan, M.,Pike, A.C.W.,von Delft, F.,Picaud, S.,Keates, T.,King, O.,Wickstroem, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Fedorov, O.,Burgess-Brown, N.,Bray, J.,Knapp, S. (deposition date: 2008-05-30, release date: 2008-09-16, Last modification date: 2018-01-24)
Primary citation	Eswaran, J.,Patnaik, D.,Filippakopoulos, P.,Wang, F.,Stein, R.L.,Murray, J.W.,Higgins, J.M.G.,Knapp, S. Structure and Functional Characterization of the Atypical Human Kinase Haspin. Proc.Natl.Acad.Sci.USA, 106:20198-, 2009 Cited by PubMed: 19918057 DOI: 10.1073/PNAS.0901989106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation