2VUW

Structure of human haspin kinase domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD A 1799

Chain	Residue
A	LYS511
A	ASP687
A	5ID1800
A	HOH2259

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 5ID A 1800

Chain	Residue
A	PHE607
A	GLY608
A	GLY609
A	ASP611
A	GLY653
A	LEU656
A	ILE686
A	IOD1799
A	HOH2025
A	HOH2167
A	HOH2168
A	HOH2214
A	HOH2396
A	HOH2397
A	ILE490
A	GLY491
A	ALA509
A	PHE605
A	GLU606

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 1801

Chain	Residue
A	HIS477
A	HIS563
A	HOH2005
A	HOH2006
A	HOH2189

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 1802

Chain	Residue
A	TYR667
A	LYS672
A	SER674
A	HOH2236

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1803

Chain	Residue
A	PRO571
A	ARG695
A	ILE698
A	VAL700
A	HOH2398

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGVFGEVFqTiadhtp............VAIK

Chain	Residue	Details
A	ILE490-LYS511

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3DLZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19918057","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---