Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Summary for 3F2N

DescriptorSerine/threonine-protein kinase haspin, (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordshaspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
Cellular locationNucleus Q8TF76
Total number of polymer chains1
Total molecular weight41428.18
Primary citation
Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Yue, W.W.,Murray, J.W.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.
Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.193301.7%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report