3F2N

Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand

Summary for 3F2N

DescriptorSerine/threonine-protein kinase haspin, (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordshaspin, germ cell associated 2, haploid germ cell specific nuclear protein kinase, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (Human)
Cellular locationNucleus Q8TF76
Total number of polymer chains1
Total molecular weight41428.18
Authors
Primary citation
Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Yue, W.W.,Murray, J.W.,Pike, A.C.W.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.
Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand
To be Published,
Experimental method
X-RAY DIFFRACTION (1.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.193301.7%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report