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2JM6
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAB
Descriptor:Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog
Authors:Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2NL9
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CRYSTAL STRUCTURE OF THE MCL-1:BIM BH3 COMPLEX
Descriptor:FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-like protein 11, ZINC ION, ...
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
2NLA
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CRYSTAL STRUCTURE OF THE MCL-1:MNOXAB BH3 COMPLEX
Descriptor:FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Phorbol-12-myristate-13-acetate-induced protein 1
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2006-10-19
Release date:2007-03-27
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proc.Natl.Acad.Sci.USA, 104, 2007
3PK1
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH THE BAXBH3 DOMAIN
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Apoptosis regulator BAX, CADMIUM ION
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2010-11-11
Release date:2010-12-29
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
3PL7
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH THE BAXBH3 DOMAIN
Descriptor:Bcl-2-like protein 1, Apoptosis regulator BAX
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2010-11-14
Release date:2010-12-29
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.613 Å)
Cite:Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis
J.Biol.Chem., 286, 2011
4BD2
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BAX DOMAIN SWAPPED DIMER IN COMPLEX WITH BIDBH3
Descriptor:APOPTOSIS REGULATOR BAX, BH3-INTERACTING DOMAIN DEATH AGONIST
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-04
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD6
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BAX DOMAIN SWAPPED DIMER IN COMPLEX WITH BAXBH3
Descriptor:APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD7
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BAX DOMAIN SWAPPED DIMER INDUCED BY OCTYLMALTOSIDE
Descriptor:APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION, CHLORIDE ION
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BD8
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BAX DOMAIN SWAPPED DIMER INDUCED BY BIMBH3 WITH CHAPS
Descriptor:APOPTOSIS REGULATOR BAX, PRASEODYMIUM ION, 1,2-ETHANEDIOL
Authors:Czabotar, P.E., Westphal, D., Adams, J.M., Colman, P.M.
Deposit date:2012-10-05
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
4BDU
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BAX BH3-IN-GROOVE DIMER (GFP)
Descriptor:GREEN FLUORESCENT PROTEIN, APOPTOSIS REGULATOR BAX
Authors:Czabotar, P.E., Colman, P.M.
Deposit date:2012-10-08
Release date:2013-02-13
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.998 Å)
Cite:Bax Crystal Structures Reveal How Bh3 Domains Activate Bax and Nucleate its Oligomerization to Induce Apoptosis.
Cell(Cambridge,Mass.), 152, 2013
2YXJ
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH ABT-737
Descriptor:Apoptosis regulator Bcl-X, CHLORIDE ION, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, ...
Authors:Czabotar, P.E., Lee, E.F., Smith, B.J., Deshayes, K., Zobel, K., Fairlie, W.D., Colman, P.M.
Deposit date:2007-04-26
Release date:2007-05-22
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family
Cell Death Differ., 14, 2007
3IO9
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BIML12Y IN COMPLEX WITH MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Czabotar, P.E., Lee, E.F., Yang, H., Sleebs, B.E., Lessene, G., Colman, P.M., Smith, B.J., Fairlie, W.D.
Deposit date:2009-08-14
Release date:2009-09-01
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
J.Biol.Chem., 284, 2009
3QKD
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH A QUINAZOLINE SULFONAMIDE INHIBITOR
Descriptor:Bcl-2-like protein 1, (R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)quinazolin-4-yl)-4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrobenzenesulfonamide, CHLORIDE ION, ...
Authors:Czabotar, P.E., Smith, B.J.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
J.Med.Chem., 54, 2011
3VPP
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CRYSTAL STRUCTURE OF THE HUMAN CLEC9A C-TYPE LECTIN-LIKE DOMAIN
Descriptor:C-type lectin domain family 9 member A, CALCIUM ION
Authors:Czabotar, P.E., Zhang, J.G., Policheni, A.N., Shortman, K., Lahoud, M.H., Colman, P.M.
Deposit date:2012-03-07
Release date:2012-04-25
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.642 Å)
Cite:The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity, 36, 2012
3VUU
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CRYSTAL STRUCTURE OF THE MEROZOITE SURFACE PROTEIN MSPDBL2 FROM P. FALCIPARUM
Descriptor:Erythrocyte membrane protein, putative, CHLORIDE ION
Authors:Czabotar, P.E., Hodder, A.N., Clarke, O.B., Lin, C.S., Smith, B.J., Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
3VUV
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CRYSTAL STRUCTURE OF THE MEROZOITE SURFACE PROTEIN MSPDBL2 FROM P. FALCIPARUM BOUND TO ZINC
Descriptor:Erythrocyte membrane protein, putative, ZINC ION
Authors:Czabotar, P.E., Hodder, A.N., Clarke, O.B., Lin, C.S., Smith, B.J., Cowman, A.F.
Deposit date:2012-07-09
Release date:2012-08-08
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.114 Å)
Cite:Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum
J.Biol.Chem., 287, 2012
3ZK6
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 2).
Descriptor:BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-01-22
Release date:2013-04-24
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLN
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 3)
Descriptor:BCL-2-LIKE PROTEIN 1, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, SULFATE ION, ...
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLO
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 6)
Descriptor:BCL-2-LIKE PROTEIN 1, 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLR
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (WEHI-539)
Descriptor:BCL-2-LIKE PROTEIN 1, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, ...
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
4BTF
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STRUCTURE OF MLKL
Descriptor:MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN, FORMIC ACID, 1,2-ETHANEDIOL
Authors:Czabotar, P.E., Murphy, J.M.
Deposit date:2013-06-16
Release date:2013-09-18
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:The Pseudokinase Mlkl Mediates Necroptosis Via a Molecular Switch Mechanism
Immunity, 39, 2013
4MWI
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CRYSTAL STRUCTURE OF THE HUMAN MLKL PSEUDOKINASE DOMAIN
Descriptor:Mixed lineage kinase domain-like protein, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, GLYCEROL
Authors:Czabotar, P.E., Murphy, J.M.
Deposit date:2013-09-25
Release date:2013-12-04
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL.
Biochem.J., 457, 2014
4TUH
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BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 10)
Descriptor:Bcl-2-like protein 1, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, ...
Authors:Czabotar, P.E., Lessense, G., Smith, B.J., Colman, P.M.
Deposit date:2014-06-24
Release date:2014-10-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
Acs Med.Chem.Lett., 5, 2014
4ZII
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CRYSTAL STRUCTURE OF CORE/LATCH DIMER OF BAXI66A IN COMPLEX WITH BIDBH3
Descriptor:Apoptosis regulator BAX, BH3-interacting domain death agonist, 1,2-ETHANEDIOL
Authors:Czabotar, P.E., Robin, A.Y., Krishna Kumar, K., Westphal, D., Wardak, A.Z., Thompson, G.V., Dewson, G., Colman, P.M.
Deposit date:2015-04-28
Release date:2015-07-22
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.191 Å)
Cite:Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.
Cell Death Dis, 6, 2015
4ZL4
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PLASMEPSIN V FROM PLASMODIUM VIVAX BOUND TO A TRANSITION STATE MIMETIC (WEHI-842)
Descriptor:Aspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ...
Authors:Czabotar, P.E., Hodder, A.N., Smith, B.J., Sleebs, B.E., Gazdic, M., Boddey, J.A., Cowman, A.F.
Deposit date:2015-05-01
Release date:2015-07-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Nat.Struct.Mol.Biol., 22, 2015