2NLA
Crystal structure of the Mcl-1:mNoxaB BH3 complex
Summary for 2NLA
Entry DOI | 10.2210/pdb2nla/pdb |
Related | 1WSX 2NL9 |
Descriptor | FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Phorbol-12-myristate-13-acetate-induced protein 1 (3 entities in total) |
Functional Keywords | apoptosis, bcl-2, mcl-1, noxa |
Biological source | Mus musculus (mouse) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 Mitochondrion : Q9JM54 |
Total number of polymer chains | 2 |
Total formula weight | 20829.65 |
Authors | Czabotar, P.E.,Colman, P.M. (deposition date: 2006-10-19, release date: 2007-03-27, Last modification date: 2023-12-27) |
Primary citation | Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA, 104:6217-6222, 2007 Cited by PubMed: 17389404DOI: 10.1073/pnas.0701297104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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