4MWI

Crystal structure of the human MLKL pseudokinase domain

Summary for 4MWI

Entry DOI	10.2210/pdb4mwi/pdb
Related	4BTF
Descriptor	Mixed lineage kinase domain-like protein, (2S)-1-[3-{[(2R)-2-hydroxypropyl]oxy}-2,2-bis({[(2R)-2-hydroxypropyl]oxy}methyl)propoxy]propan-2-ol, GLYCEROL, ... (4 entities in total)
Functional Keywords	pseudokinase, necroptosis, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q8NB16
Total number of polymer chains	1
Total formula weight	34028.35
Authors	Czabotar, P.E.,Murphy, J.M. (deposition date: 2013-09-25, release date: 2013-12-04, Last modification date: 2023-09-20)
Primary citation	Murphy, J.M.,Lucet, I.S.,Hildebrand, J.M.,Tanzer, M.C.,Young, S.N.,Sharma, P.,Lessene, G.,Alexander, W.S.,Babon, J.J.,Silke, J.,Czabotar, P.E. Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL. Biochem.J., 457:369-377, 2014 Cited by PubMed: 24219132 DOI: 10.1042/BJ20131270 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation