Author results

2OM7
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STRUCTURAL BASIS FOR INTERACTION OF THE RIBOSOME WITH THE SWITCH REGIONS OF GTP-BOUND ELONGATION FACTORS
Descriptor:Fragment of 16S rRNA (h14), Fragment of 16S rRNA (h15), Fragment of 16S rRNA (h44), ...
Authors:Connell, S.R., Wilson, D.N., Rost, M., Schueler, M., Giesebrecht, J., Dabrowski, M., Mielke, T., Fucini, P., Spahn, C.M.T.
Deposit date:2007-01-21
Release date:2008-01-15
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors.
Mol.Cell, 25, 2007
3DEG
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COMPLEX OF ELONGATING ESCHERICHIA COLI 70S RIBOSOME AND EF4(LEPA)-GMPPNP
Descriptor:A/L-tRNA, P-tRNA, 30S RNA helix 8, ...
Authors:Connell, S.R., Topf, M., Qin, Y., Wilson, D.N., Mielke, T., Fucini, P., Nierhaus, K.H., Spahn, C.M.T.
Deposit date:2008-06-10
Release date:2008-08-19
Last modified:2014-04-16
Method:ELECTRON MICROSCOPY (10.9 Å)
Cite:A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
2NOQ
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STRUCTURE OF RIBOSOME-BOUND CRICKET PARALYSIS VIRUS IRES RNA
Descriptor:CrPV IRES, 18S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Schuler, M., Connell, S.R., Lescoute, A., Giesebrecht, J., Dabrowski, M., Schroeer, B., Mielke, T., Penczek, P.A., Westhof, E., Spahn, C.M.T.
Deposit date:2006-10-26
Release date:2006-11-21
Last modified:2012-02-15
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Structure of the ribosome-bound cricket paralysis virus IRES RNA.
Nat.Struct.Mol.Biol., 13, 2006
2ZJP
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THIOPEPTIDE ANTIBIOTIC NOSIHEPTIDE BOUND TO THE LARGE RIBOSOMAL SUBUNIT OF DEINOCOCCUS RADIODURANS
Descriptor:50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L34, 50S RIBOSOMAL PROTEIN L35, ...
Authors:Harms, J.M., Wilson, D.N., Schluenzen, F., Connell, S.R., Stachelhaus, T., Zaborowska, Z., Spahn, C.M.T., Fucini, P.
Deposit date:2008-03-07
Release date:2008-06-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
Mol.Cell, 30, 2008
2ZJQ
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INTERACTION OF L7 WITH L11 INDUCED BY MICROCCOCIN BINDING TO THE DEINOCOCCUS RADIODURANS 50S SUBUNIT
Descriptor:ribosomal 23S RNA, ribosomal 5S RNA, 50S ribosomal protein L2, ...
Authors:Harms, J.M., Wilson, D.N., Schluenzen, F., Connell, S.R., Stachelhaus, T., Zaborowska, Z., Spahn, C.M.T., Fucini, P.
Deposit date:2008-03-08
Release date:2008-06-17
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.
Mol.Cell, 30, 2008
2ZJR
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REFINED NATIVE STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT (50S) FROM DEINOCOCCUS RADIODURANS
Descriptor:ribosomal 23S RNA, ribosomal 5S RNA, 50S ribosomal protein L2, ...
Authors:Harms, J.M., Wilson, D.N., Schluenzen, F., Connell, S.R., Stachelhaus, T., Zaborowska, Z., Spahn, C.M.T., Fucini, P.
Deposit date:2008-03-08
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.
Mol.Cell, 30, 2008
3CF5
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THIOPEPTIDE ANTIBIOTIC THIOSTREPTON BOUND TO THE LARGE RIBOSOMAL SUBUNIT OF DEINOCOCCUS RADIODURANS
Descriptor:50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L34, 50S RIBOSOMAL PROTEIN L35, ...
Authors:Harms, J.M., Wilson, D.N., Schluenzen, F., Connell, S.R., Stachelhaus, T., Zaborowska, Z., Spahn, C.M.T., Fucini, P.
Deposit date:2008-03-02
Release date:2008-06-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
Mol.Cell, 30, 2008
3DLL
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THE OXAZOLIDINONE ANTIBIOTICS PERTURB THE RIBOSOMAL PEPTIDYL-TRANSFERASE CENTER AND EFFECT TRNA POSITIONING
Descriptor:rRNA-23S ribosomal RNA, rRNA-5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Wilson, D.N., Schluenzen, F., Harms, J.M., Starosta, A.L., Connell, S.R., Fucini, P.
Deposit date:2008-06-27
Release date:2008-09-16
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Proc.Natl.Acad.Sci.Usa, 105, 2008
4V5M
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TRNA TRANLOCATION ON THE 70S RIBOSOME: THE PRE-TRANSLOCATIONAL TRANSLOCATION INTERMEDIATE TI(PRE)
Descriptor:16S RRNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ratje, A.H., Loerke, J., Mikolajka, A., Bruenner, M., Hildebrand, P.W., Starosta, A.L., Doenhoefer, A., Connell, S.R., Fucini, P., Mielke, T., Whitford, P.C., Onuchic, J.N., Yu, Y., Sanbonmatsu, K.Y., Hartmann, R.K., Penczek, P.A., Wilson, D.N., Spahn, C.M.T.
Deposit date:2010-10-01
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
4V5N
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TRNA TRANSLOCATION ON THE 70S RIBOSOME: THE POST- TRANSLOCATIONAL TRANSLOCATION INTERMEDIATE TI(POST)
Descriptor:16S RRNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Ratje, A.H., Loerke, J., Mikolajka, A., Bruenner, M., Hildebrand, P.W., Starosta, A.L., Doenhoefer, A., Connell, S.R., Fucini, P., Mielke, T., Whitford, P.C., Onuchic, J.N., Yu, Y., Sanbonmatsu, K.Y., Hartmann, R.K., Penczek, P.A., Wilson, D.N., Spahn, C.M.T.
Deposit date:2010-10-21
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
4V8V
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STRUCTURE AND CONFORMATIONAL VARIABILITY OF THE MYCOBACTERIUM TUBERCULOSIS FATTY ACID SYNTHASE MULTIENZYME COMPLEX
Descriptor:TYPE-I FATTY ACID SYNTHASE, FLAVIN MONONUCLEOTIDE
Authors:Ciccarelli, L., Connell, S.R., Enderle, M., Mills, D.J., Vonck, J., Grininger, M.
Deposit date:2013-04-18
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex.
Structure, 21, 2013
4V8W
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STRUCTURE AND CONFORMATIONAL VARIABILITY OF THE MYCOBACTERIUM TUBERCULOSIS FATTY ACID SYNTHASE MULTIENZYME COMPLEX
Descriptor:TYPE-I FATTY ACID SYNTHASE, FLAVIN MONONUCLEOTIDE
Authors:Ciccarelli, L., Connell, S.R., Enderle, M., Mills, D.J., Vonck, J., Grininger, M.
Deposit date:2013-04-18
Release date:2014-07-09
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (17.5 Å)
Cite:Structure and Conformational Variability of the Mycobacterium Tuberculosis Fatty Acid Synthase Multienzyme Complex.
Structure, 21, 2013
4YHH
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CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH TIGECYCLINE
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Schedlbauer, A., Kaminishi, T., Ochoa-Lizarralde, B., Dhimole, N., Zhou, S., Lopez-Alonso, J.P., Connell, S.R., Fucini, P.
Deposit date:2015-02-27
Release date:2015-04-08
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (3.417 Å)
Cite:Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.
Antimicrob.Agents Chemother., 59, 2015
5DM6
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CRYSTAL STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS
Descriptor:50S ribosomal protein L1, 50S ribosomal protein L2, 50S ribosomal protein L3, ...
Authors:Kaminishi, T., Schedlbauer, A., Ochoa-Lizarralde, B., Connell, S.R., Fucini, P.
Deposit date:2015-09-08
Release date:2015-11-11
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
5DM7
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CRYSTAL STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH HYGROMYCIN A
Descriptor:50S ribosomal protein L1, 50S ribosomal protein L2, 50S ribosomal protein L3, ...
Authors:Kaminishi, T., Schedlbauer, A., Ochoa-Lizarralde, B., Connell, S.R., Fucini, P.
Deposit date:2015-09-08
Release date:2015-11-11
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
5IWA
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CRYSTAL STRUCTURE OF THE 30S RIBOSOMAL SUBUNIT FROM THERMUS THERMOPHILUS IN COMPLEX WITH THE GE81112 PEPTIDE ANTIBIOTIC
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Schedlbauer, A., Kaminishi, T., Ochoa-Lizarralde, B., Chieko, N., Masahito, K., Takemoto, C., Yokoyama, S., Connell, S.R., Fucini, P.
Deposit date:2016-03-22
Release date:2016-04-27
Last modified:2017-04-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Proc.Natl.Acad.Sci.USA, 113, 2016
5NO2
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S4, 30S ribosomal protein S5, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-24
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5NO3
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITHOUT US3)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S4, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-31
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5NO4
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RSGA-GDPNP BOUND TO THE 30S RIBOSOMAL SUBUNIT (RSGA ASSEMBLY INTERMEDIATE WITH US3)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Lopez-Alonso, J.P., Kaminishi, T., Kikuchi, T., Hirata, Y., Iturrioz, I., Dhimole, N., Schedlbauer, A., Hase, Y., Goto, S., Kurita, D., Muto, A., Zhou, S., Naoe, C., Mills, D.J., Gil-Carton, D., Takemoto, C., Himeno, H., Fucini, P., Connell, S.R.
Deposit date:2017-04-10
Release date:2017-05-31
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (5.16 Å)
Cite:RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket.
Nucleic Acids Res., 45, 2017
5ME0
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STRUCTURE OF THE 30S PRE-INITIATION COMPLEX 1 (30S IC-1) STALLED BY GE81112
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Lopez-Alonso, J.P., Fabbretti, A., Kaminishi, T., Iturrioz, I., Brandi, L., Gil Carton, D., Gualerzi, C., Fucini, P., Connell, S.
Deposit date:2016-11-14
Release date:2017-01-11
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (13.5 Å)
Cite:Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
5ME1
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STRUCTURE OF THE 30S PRE-INITIATION COMPLEX 2 (30S IC-2) STALLED BY GE81112
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Lopez-Alonso, J.P., Fabbretti, A., Kaminishi, T., Iturrioz, I., Brandi, L., Gil Carton, D., Gualerzi, C., Fucini, P., Connell, S.
Deposit date:2016-11-14
Release date:2017-01-11
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (13.5 Å)
Cite:Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
4V68
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T. THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MRNA, TRNAS AND EF-TU.GDP.KIRROMYCIN TERNARY COMPLEX, FITTED TO A 6.4 A CRYO-EM MAP.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S4, ...
Authors:Schuette, J.-C., Spahn, C.M.T.
Deposit date:2008-12-11
Release date:2014-07-09
Last modified:2015-03-25
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:GTPase activation of elongation factor EF-Tu by the ribosome during decoding
Embo J., 28, 2009