4YHH

Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with tigecycline

Summary for 4YHH

Related2ZM6
Descriptor16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... (24 entities in total)
Functional Keywordsprotein synthesis, ribosome, antibiotic
Biological sourceThermus thermophilus HB8
Total number of polymer chains21
Total molecular weight765474.86
Authors
Schedlbauer, A.,Kaminishi, T.,Ochoa-Lizarralde, B.,Dhimole, N.,Zhou, S.,Lopez-Alonso, J.P.,Connell, S.R.,Fucini, P. (deposition date: 2015-02-27, release date: 2015-04-08, Last modification date: 2016-02-03)
Primary citation
Schedlbauer, A.,Kaminishi, T.,Ochoa-Lizarralde, B.,Dhimole, N.,Zhou, S.,Lopez-Alonso, J.P.,Connell, S.R.,Fucini, P.
Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome.
Antimicrob.Agents Chemother., 59:2849-2854, 2015
PubMed: 25753625 (PDB entries with the same primary citation)
DOI: 10.1128/AAC.04895-14
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.417 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.278247.7%21.1%6.0%0.42MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4yhh
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Molmil generated image of 4yhh
rotated about x axis by 90°
Molmil generated image of 4yhh
rotated about y axis by 90°