Author results

6VAB
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MOUSE RETROMER SUB-STRUCTURE: VPS35/VPS35 FLAT DIMER
Descriptor:Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
Authors:Kendall, A.K., Jackson, L.P.
Deposit date:2019-12-17
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
Structure, 2020
6VAC
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MOUSE RETROMER (VPS26/VPS35/VPS29) HETEROTRIMER
Descriptor:Vacuolar protein sorting-associated protein 35, Vacuolar protein sorting-associated protein 26A, Vacuolar protein sorting-associated protein 29
Authors:Kendall, A.K., Jackson, L.P.
Deposit date:2019-12-17
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
Structure, 2020
6JV3
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CRYSTAL STRUCTURE OF 5-HYDOXYLMETHYLCYTOSINE CONTAINING DECAMER DSDNA
Descriptor:DNA (5'-D(*CP*CP*AP*GP*(5HC)P*GP*CP*TP*GP*G)-3')
Authors:Zhang, L., Wang, Y.X.
Deposit date:2019-04-15
Release date:2019-07-31
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.
Chem Sci, 10, 2019
6JV5
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CRYSTAL STRUCTURE OF 5-METHYLCYTOSINE CONTAINING DECAMER DSDNA
Descriptor:DNA (5'-D(*CP*CP*AP*GP*(5CM)P*GP*CP*TP*GP*G)-3')
Authors:Zhang, L., Wang, Y.X.
Deposit date:2019-04-15
Release date:2019-07-31
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.
Chem Sci, 10, 2019
6A8O
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CRYSTAL STRUCTURES OF THE SERINE PROTEASE DOMAIN OF MURINE PLASMA KALLIKREIN WITH PEPTIDE INHIBITOR MUPAIN-1-16
Descriptor:Plasma kallikrein, peptide inhibitor,, ALPHA-D-MANNOSE, ...
Authors:Xu, M., Jiang, L., Huang, M.
Deposit date:2018-07-09
Release date:2019-07-10
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Febs Lett., 592, 2018
6K3H
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CRYSTALLOGRAPHIC ANALYSIS OF NUCLEOSIDE DIPHOSPHATE KINASE (NDK) FROM ASPERGILLUS FLAVUS
Descriptor:Nucleoside diphosphate kinase
Authors:Wang, Y., Wang, S., Wang, S.H.
Deposit date:2019-05-18
Release date:2019-07-03
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (2.179 Å)
Cite:Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungusAspergillus flavus.
J.Biol.Chem., 294, 2019
6O8B
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CRYSTAL STRUCTURE OF STING CTD IN COMPLEX WITH TBK1
Descriptor:Stimulator of interferon genes protein, Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
Authors:Li, P., Zhao, B., Du, F.
Deposit date:2019-03-09
Release date:2019-05-22
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6O8C
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CRYSTAL STRUCTURE OF STING CTT IN COMPLEX WITH TBK1
Descriptor:Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
Authors:Li, P., Zhao, B., Du, F.
Deposit date:2019-03-09
Release date:2019-05-22
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
6A8G
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:muPAin-1-IG, Urokinase-type plasminogen activator chain B, PHOSPHATE ION
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-08
Release date:2019-02-20
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
6A8N
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG-2 IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-09
Release date:2019-02-20
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides.
J.Med.Chem., 62, 2019
5ZAS
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CRYSTAL STRUCTURE OF 5-FORMYLCYTOSINE CONTAINING DECAMER DSDNA
Descriptor:DNA (5'-D(*CP*CP*AP*GP*(5FC)P*GP*CP*TP*GP*G)-3'), BICARBONATE ION
Authors:Fu, T.R., Zhang, L.
Deposit date:2018-02-08
Release date:2019-02-13
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.
Chem Sci, 10, 2019
5ZAT
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CRYSTAL STRUCTURE OF 5-CARBOXYLCYTOSINE CONTAINING DECAMER DSDNA
Descriptor:DNA (5'-D(*CP*CP*AP*GP*(CAC)P*GP*CP*TP*GP*G)-3')
Authors:Fu, T.R., Zhang, L.
Deposit date:2018-02-08
Release date:2019-02-13
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.
Chem Sci, 10, 2019
6IRA
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A NMDA RECEPTOR IN THE GLUTAMATE/GLYCINE-BOUND STATE AT PH 7.8
Descriptor:Glutamate receptor ionotropic, NMDA 2A, NMDA 1
Authors:Zhang, J., Chang, S., Zhang, X., Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6IRF
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A NMDA RECEPTOR IN THE GLUTAMATE/GLYCINE-BOUND STATE AT PH 6.3, CLASS I
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J., Chang, S., Zhang, X., Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (5.1 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6IRG
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A NMDA RECEPTOR IN THE GLUTAMATE/GLYCINE-BOUND STATE AT PH 6.3, CLASS II
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J., Chang, S., Zhang, X., Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6IRH
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A NMDA RECEPTOR IN THE GLUTAMATE/GLYCINE-BOUND STATE AT PH 6.3, CLASS III
Descriptor:Glutamate receptor ionotropic, NMDA 1, NMDA 2A
Authors:Zhang, J., Chang, S., Zhang, X., Zhu, S.
Deposit date:2018-11-12
Release date:2019-01-16
Last modified:2019-06-05
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
5WXF
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CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH UPAIN-2-2
Descriptor:Urokinase-type plasminogen activator chain B, upain-2-2 peptide, SULFATE ION
Authors:Jiang, L., Huang, M.
Deposit date:2017-01-07
Release date:2018-07-11
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
5WXO
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CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH UPAIN-2-2-W3A
Descriptor:Urokinase-type plasminogen activator chain B, upain-2-2-W3A peptide
Authors:Jiang, L., Huang, M.
Deposit date:2017-01-08
Release date:2018-07-11
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
5WXP
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CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH UPAIN-2-3-W3A
Descriptor:Urokinase-type plasminogen activator chain B, upain-2-3-W3A peptide, ALANINE, ...
Authors:Jiang, L., Huang, M.
Deposit date:2017-01-08
Release date:2018-07-11
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018
6CKU
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SOLUTION STRUCTURE OF THE ZEBRAFISH GRANULIN AAE
Descriptor:Granulin-AaE
Authors:Wang, P., Ni, F.
Deposit date:2018-02-28
Release date:2018-06-13
Last modified:2020-01-08
Method:SOLUTION NMR
Cite:Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities.
Protein Sci., 27, 2018
5XAG
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-COMPOUND Z2 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, H., Luo, C., Wang, Y.
Deposit date:2017-03-12
Release date:2018-01-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
5XAF
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CRYSTAL STRUCTURE OF TUBULIN-STATHMIN-TTL-COMPOUND Z1 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Zhang, H., Luo, C., Wang, Y.
Deposit date:2017-03-12
Release date:2017-12-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
5GVT
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CRYSTAL STRUCTURES OF THE SERINE PROTEASE DOMAIN OF MURINE PLASMA KALLIKREIN
Descriptor:Plasma kallikrein, BETA-D-MANNOSE, ALPHA-D-MANNOSE
Authors:Xu, M., Jiang, L., Huang, M.
Deposit date:2016-09-06
Release date:2017-11-22
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal Structures of the Serine Protease Domain of Murine Plasma Kallikrein
Chin.J.Struct.Chem., 36, 2017
5FGL
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CO-CRYSTAL STRUCTURE OF NICR2_HSP
Descriptor:NicR, 4-oxidanylidene-4-(6-oxidanylidene-1~{H}-pyridin-3-yl)butanoic acid
Authors:Zhang, K., Tang, H., Wu, G., Wang, W., Hu, H., Xu, P.
Deposit date:2015-12-21
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Co-crystal Structure of NicR2_Hsp
To Be Published
5FHP
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SEMET REGULATOR OF NICOTINE DEGRADATION
Descriptor:NicR, GLYCEROL, MALONIC ACID
Authors:Zhang, K., Tang, H., Wu, G., Wang, W., Hu, H., Xu, P.
Deposit date:2015-12-22
Release date:2016-12-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Co-crystal Structure of NicR2_Hsp
To Be Published
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