Author results

1PK0
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CRYSTAL STRUCTURE OF THE EF3-CAM COMPLEXED WITH PMEAPP
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Shen, Y., Tang, W.J.
Deposit date:2003-06-04
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
1SK6
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CRYSTAL STRUCTURE OF THE ADENYLYL CYCLASE DOMAIN OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN, 3',5' CYCLIC AMP (CAMP), AND PYROPHOSPHATE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin, YTTERBIUM (III) ION, ...
Authors:Guo, Q., Shen, Y., Zhukovskaya, N.L., Tang, W.J.
Deposit date:2004-03-04
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
J.Biol.Chem., 279, 2004
1XFU
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) TRUNCATION MUTANT, EF-DELTA 64 IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFV
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3' DEOXY-ATP
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Q., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFW
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN AND 3'5' CYCLIC AMP (CAMP)
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFX
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 10 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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CRYSTAL STRUCTURE OF ANTHRAX EDEMA FACTOR (EF) IN COMPLEX WITH CALMODULIN IN THE PRESENCE OF 1 MILLIMOLAR EXOGENOUSLY ADDED CALCIUM CHLORIDE
Descriptor:Calmodulin-sensitive adenylate cyclase, Calmodulin 2, MAGNESIUM ION, ...
Authors:Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1YRT
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CRYSTAL STRUCTURE ANALYSIS OF THE ADENYLYL CYCLAES CATALYTIC DOMAIN OF ADENYLYL CYCLASE TOXIN OF BORDETELLA PERTUSSIS IN PRESENCE OF C-TERMINAL CALMODULIN
Descriptor:Bifunctional hemolysin-adenylate cyclase, Calmodulin, CALCIUM ION
Authors:Guo, Q., Shen, Y., Lee, Y.S., Gibbs, C.S., Mrksich, M., Tang, W.J.
Deposit date:2005-02-04
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
1YRU
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CRYSTAL STRUCTURE ANALYSIS OF THE ADENYLYL CYCLAES CATALYTIC DOMAIN OF ADENYLYL CYCLASE TOXIN OF BORDETELLA PERTUSSIS IN PRESENCE OF C-TERMINAL CALMODULIN AND 1MM CALCIUM CHLORIDE
Descriptor:Bifunctional hemolysin-adenylate cyclase, Calmodulin, CALCIUM ION
Authors:Guo, Q., Shen, Y., Tang, W.J.
Deposit date:2005-02-04
Release date:2005-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
1ZOT
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CRYSTAL STRUCTURE ANALYSIS OF THE CYAA/C-CAM WITH PMEAPP
Descriptor:CyaA with C-terminal Calmodulin, Calmodulin, MAGNESIUM ION, ...
Authors:Guo, Q., Tang, W.J.
Deposit date:2005-05-13
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
2COL
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CRYSTAL STRUCTURE ANALYSIS OF CYAA/C-CAM WITH PYROPHOSPHATE
Descriptor:Bifunctional hemolysin-adenylate cyclase, Calmodulin, MAGNESIUM ION, ...
Authors:Guo, Q., Tang, W.J., Shen, Y.
Deposit date:2005-05-18
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
2J9J
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ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR JG-365
Descriptor:PROTEASE, INHIBITOR MOLECULE JG365, SULFATE ION, ...
Authors:Malito, E., Shen, Y., Johnson, E.C.B., Tang, W.J.
Deposit date:2006-11-11
Release date:2007-08-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.
J.Mol.Biol., 373, 2007
2J9K
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ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR MVT-101
Descriptor:PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ...
Authors:Malito, E., Shen, Y., Johnson, E.C.B., Tang, W.J.
Deposit date:2006-11-11
Release date:2007-08-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.
J.Mol.Biol., 373, 2007
2JBU
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME COMPLEXED WITH CO- PURIFIED PEPTIDES.
Descriptor:INSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE
Authors:Im, H., Shen, Y., Tang, W.J.
Deposit date:2006-12-11
Release date:2007-07-03
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2JE4
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ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE IN COMPLEX WITH JG-365
Descriptor:PROTEASE, INHIBITOR MOLECULE JG365, ACETATE ION, ...
Authors:Malito, E., Johnson, E.C.B., Tang, W.J.
Deposit date:2007-01-15
Release date:2007-08-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease.
J.Am.Chem.Soc., 129, 2007
2JG4
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SUBSTRATE-FREE IDE STRUCTURE IN ITS CLOSED CONFORMATION
Descriptor:INSULIN DEGRADING ENZYME, ZINC ION, 1,4-DIETHYLENE DIOXIDE
Authors:Malito, E., Tang, W.J.
Deposit date:2007-02-07
Release date:2007-07-03
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2PQ3
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N-TERMINAL CALMODULIN ZN-TRAPPED INTERMEDIATE
Descriptor:Calmodulin, CACODYLATE ION, ZINC ION
Authors:Warren, J.T., Guo, Q., Tang, W.J.
Deposit date:2007-05-01
Release date:2007-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A 1.3-A structure of zinc-bound N-terminal domain of calmodulin elucidates potential early ion-binding step.
J.Mol.Biol., 374, 2007
2WBY
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WC0
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CRYSTAL STRUCTURE OF HUMAN INSULIN DEGRADING ENZYME IN COMPLEX WITH IODINATED INSULIN
Descriptor:INSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M., Guo, Q., Malito, E., Schilling, A.B., Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WK3
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH AMYLOID-BETA (1-42)
Descriptor:INSULIN DEGRADING ENZYME, BETA-AMYLOID PROTEIN 42, ZINC ION
Authors:Guo, Q., Tang, W.J.
Deposit date:2009-06-05
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme.
J.Mol.Biol., 395, 2010
3CQF
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CRYSTAL STRUCTURE OF ANTHROLYSIN O (ALO)
Descriptor:Thiol-activated cytolysin
Authors:Bourdeau, R.W., Malito, E., Tang, W.J.
Deposit date:2008-04-02
Release date:2009-03-17
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis
J.Biol.Chem., 284, 2009
3CWW
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CRYSTAL STRUCTURE OF IDE-BRADYKININ COMPLEX
Descriptor:Insulin-degrading enzyme, bradykinin N-terminal tetrapeptide analogue, ZINC ION, ...
Authors:Malito, E., Tang, W.J.
Deposit date:2008-04-23
Release date:2008-11-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
3E4A
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HUMAN IDE-INHIBITOR COMPLEX AT 2.6 ANGSTROM RESOLUTION
Descriptor:Insulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ...
Authors:Malito, E., Leissring, M.A., Choi, S., Cuny, G.D., Tang, W.J.
Deposit date:2008-08-11
Release date:2009-05-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
3H44
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CRYSTAL STRUCTURE OF INSULIN DEGRADING ENZYME IN COMPLEX WITH MACROPHAGE INFLAMMATORY PROTEIN 1 ALPHA
Descriptor:Insulin-degrading enzyme, C-C motif chemokine 3, 1,4-DIETHYLENE DIOXIDE, ...
Authors:Ren, M., Guo, Q., Tang, W.J.
Deposit date:2009-04-17
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme
To be Published