Author results

6J9A
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA VAL1 IN COMPLEX WITH FLC DNA FRAGMENT
分子名称:B3 domain-containing transcription repressor VAL1, DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*TP*G)-3'), DNA (5'-D(*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*TP*C)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (2.915 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6J9B
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ARABIDOPSIS FUS3-DNA COMPLEX
分子名称:B3 domain-containing transcription factor FUS3, DNA (5'-D(*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*TP*C)-3'), DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*TP*G)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6J9C
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA TRANSCRIPTION FACTOR LEC2-DNA COMPLEX
分子名称:B3 domain-containing transcription factor LEC2, DNA (5'-D(*GP*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*T)-3'), DNA (5'-D(*CP*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*T)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6NF0
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NOCTURNIN WITH BOUND NADPH SUBSTRATE
分子名称:Nocturnin, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Estrella, M.A., Du, J., Korennykh, A.
登録日2018-12-18
公開日2019-05-01
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The metabolites NADP+and NADPH are the targets of the circadian protein Nocturnin (Curled).
Nat Commun, 10, 2019
6IP0
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH AKG
分子名称:Transcription factor jumonji (Jmj) family protein, 2-OXOGLUTARIC ACID, NICKEL (II) ION, ...
著者Hu, H., Du, J.
登録日2018-11-01
公開日2019-04-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
6IP4
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH NOG AND AN H3K27ME3 PEPTIDE
分子名称:Arabidopsis JMJ13, Histone H3.2, NICKEL (II) ION, ...
著者Hu, H., Du, J.
登録日2018-11-02
公開日2019-04-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
6C2R
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AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
6C2T
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AURORA A LIGAND COMPLEX
分子名称:Aurora kinase A, (2S,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-2-methyl-4-({3-[(1,3-thiazol-2-yl)amino]isoquinolin-1-yl}methyl)piperidine-4-carboxylic acid, DIMETHYL SULFOXIDE, ...
著者Antonysamy, S., Pustilnik, A., Manglicmot, D., Froning, K., Weichert, K., Wasserman, S.
登録日2018-01-08
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.
Cancer Discov, 9, 2019
6MO7
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-((4-(3-(N-CYCLOPENTYLSULFAMOYL)-4-METHYLPHENYL)-3-METHYLISOXAZOL-5-YL)METHYL)ACETAMIDE INHIBITOR
分子名称:Bromodomain-containing protein 2, N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO8
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH 4,4'-(QUINOLINE-5,7-DIYL)BIS(3,5-DIMETHYLISOXAZOLE) INHIBITOR
分子名称:Bromodomain-containing protein 2, 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline, SULFATE ION
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO9
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH N-CYCLOPENTYL-7-(3,5-DIMETHYLISOXAZOL-4-YL)QUINOLINE-5-SULFONAMIDE INHIBITOR
分子名称:Bromodomain-containing protein 2, N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MOA
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C-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH 4-(2-CYCLOPROPYL-7-(6-METHYLQUINOLIN-5-YL)-1H-BENZO[D]IMIDAZOL-5-YL)-3,5-DIMETHYLISOXAZOLE INHIBITOR
分子名称:Bromodomain-containing protein 2, 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole, GLYCEROL
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.271 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
5ZWX
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CRYSTAL STRUCTURE OF RAPHANUS SATIVUS AGDP1 AGD12 IN COMPLEX WITH AN H3K9ME2 PEPTIDE
分子名称:DUF724 domain-containing protein 6-like, H3(1-15)K9me2 peptide
著者Du, X., Du, J.
登録日2018-05-17
公開日2018-11-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZWZ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGDP1 AGD34
分子名称:Agenet domain-containing protein
著者Du, X., Du, J.
登録日2018-05-17
公開日2018-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
6DRJ
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STRUCTURE OF TRPM2 ION CHANNEL RECEPTOR BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY, ADPR/CA2+ BOUND STATE
分子名称:Transient receptor potential cation channel, subfamily M, member 2, ...
著者Du, J., Lu, W., Huang, Y., Winkler, P., Sun, W.
登録日2018-06-12
公開日2018-09-19
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Nature, 562, 2018
6DRK
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STRUCTURE OF TRPM2 ION CHANNEL RECEPTOR BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY, APO STATE
分子名称:Transient receptor potential cation channel, subfamily M, member 2
著者Du, J., Lu, W., Huang, Y., Winkler, P., Sun, W.
登録日2018-06-12
公開日2018-09-19
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Nature, 562, 2018
6MAL
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STRUCTURE OF HUMAN NOCTURNIN C-TERMINAL DOMAIN
分子名称:Nocturnin, MAGNESIUM ION
著者Estrella, M.A., Du, J., Korennykh, A.
登録日2018-08-28
公開日2018-09-05
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Human Nocturnin Catalytic Domain.
Sci Rep, 8, 2018
6A5K
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 1
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5M
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 2
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5N
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH METHYLATED DNA
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, DNA (5'-D(*GP*AP*GP*TP*AP*CP*TP*(5CM)P*AP*GP*CP*AP*GP*T)-3'), ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5Z8L
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS IN COMPLEX WITH AN H3K27ME3 PEPTIDE
分子名称:Chromatin remodeling protein EBS, H3K27me3 peptide, ZINC ION
著者Yang, Z., Du, J.
登録日2018-01-31
公開日2018-07-25
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
5Z8N
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA EBS C-TERMINAL DELETION CONSTRUCT IN COMPLEX WITH AN H3K4ME2 PEPTIDE
分子名称:Chromatin remodeling protein EBS, H3K4me2 peptide, ZINC ION
著者Yang, Z., Du, J.
登録日2018-01-31
公開日2018-07-25
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis.
Nat. Genet., 50, 2018
5ZNP
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K4ME3 PEPTIDE
分子名称:SHORT LIFE family protein, 15-mer peptide from Histone H3.2, ZINC ION
著者Lv, X., Du, J.
登録日2018-04-10
公開日2018-07-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
5ZNR
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K27ME3 PEPTIDE
分子名称:SHORT LIFE family protein, 17-mer peptide from Histone H3.2, ZINC ION, ...
著者Lv, X., Du, J.
登録日2018-04-10
公開日2018-07-18
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
5XO0
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CRYSTAL STRUCTURE OF THE ISOCHORISMATASE DOMAIN OF ANGB FROM VIBRIO ANGUILLARUM 775
分子名称:Ischorismate lyase
著者Ma, Q., Du, J.
登録日2017-05-25
公開日2018-05-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structures of the isochorismatase domains from Vibrio anguillarum 775
To Be Published