3JAF

Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state

Summary for 3JAF

Related3JAD 3JAE
EMDB information6346 6344 6345
DescriptorGlycine receptor subunit alphaZ1, N-ACETYL-D-GLUCOSAMINE, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside (3 entities in total)
Functional Keywordscys loop receptor, alpha-1 glycine receptor, glycine, ivermectin, signaling protein
Biological sourceDanio rerio (zebra fish)
Total number of polymer chains5
Total molecular weight202705.24
Authors
Du, J.,Lu, W.,Wu, S.P.,Cheng, Y.F.,Gouaux, E. (deposition date: 2015-06-08, release date: 2015-09-09, Last modification date: 2018-07-18)
Primary citation
Du, J.,Lu, W.,Wu, S.,Cheng, Y.,Gouaux, E.
Glycine receptor mechanism elucidated by electron cryo-microscopy.
Nature, 526:224-229, 2015
PubMed: 26344198 (PDB entries with the same primary citation)
DOI: 10.1038/nature14853
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.801 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1900MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures