3JAF
Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016594 | molecular_function | glycine binding |
| A | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016594 | molecular_function | glycine binding |
| B | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016594 | molecular_function | glycine binding |
| C | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016594 | molecular_function | glycine binding |
| D | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0016594 | molecular_function | glycine binding |
| E | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS00236 |
| Number of Residues | 15 |
| Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMdLknFPmDvqtC |
| Chain | Residue | Details |
| A | CYS154-CYS168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 105 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | TYR239-ILE260 | |
| A | TYR239-ILE260 | |
| B | TYR239-ILE260 | |
| C | TYR239-ILE260 | |
| D | TYR239-ILE260 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 445 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | ASN261-ALA265 | |
| A | ASN261-ALA265 | |
| B | ASN261-ALA265 | |
| C | ASN261-ALA265 | |
| D | ASN261-ALA265 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | PRO266-SER286 | |
| A | PRO266-SER286 | |
| B | PRO266-SER286 | |
| C | PRO266-SER286 | |
| D | PRO266-SER286 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | ARG287-LYS297 | |
| A | ARG287-LYS297 | |
| B | ARG287-LYS297 | |
| C | ARG287-LYS297 | |
| D | ARG287-LYS297 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | ALA298-ALA318 | |
| A | ALA298-ALA318 | |
| B | ALA298-ALA318 | |
| C | ALA298-ALA318 | |
| D | ALA298-ALA318 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P23415 |
| Chain | Residue | Details |
| E | GLU208 | |
| E | ASP210 | |
| E | HIS231 | |
| A | GLU208 | |
| A | ASP210 | |
| A | HIS231 | |
| B | GLU208 | |
| B | ASP210 | |
| B | HIS231 | |
| C | GLU208 | |
| C | ASP210 | |
| C | HIS231 | |
| D | GLU208 | |
| D | ASP210 | |
| D | HIS231 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | TYR218 | |
| A | TYR218 | |
| B | TYR218 | |
| C | TYR218 | |
| D | TYR218 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | LEU277 | |
| A | LEU277 | |
| B | LEU277 | |
| C | LEU277 | |
| D | LEU277 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26344198 |
| Chain | Residue | Details |
| E | ASN54 | |
| A | ASN54 | |
| B | ASN54 | |
| C | ASN54 | |
| D | ASN54 |
