Crystal structure of the Fab fragment of anti-CD20 antibody Ofatumumab

Summary for 3GIZ

DescriptorFab fragment of anti-CD20 antibody Ofatumumab, light chain, Fab fragment of anti-CD20 antibody Ofatumumab, heavy chain, ZINC ION, ... (4 entities in total)
Functional Keywordscd20, 2f2, ofatumumab, hu-maxcd20, fab, antibody, fully human antibody, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight47088.48
Du, J.,Yang, H.,Ding, J. (deposition date: 2009-03-07, release date: 2009-05-26, Last modification date: 2011-07-13)
Primary citation
Du, J.,Yang, H.,Guo, Y.,Ding, J.
Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20
Mol.Immunol., 46:2419-2423, 2009
PubMed: 19427037 (PDB entries with the same primary citation)
DOI: 10.1016/j.molimm.2009.04.009
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.197607.4%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution