Author results

6PUO
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HUMAN TRPM2 IN THE APO STATE
分子名称:Transient receptor potential cation channel subfamily M member 2
著者Du, J., Lu, W., Huang, Y.
登録日2019-07-18
公開日2019-09-25
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
6PUR
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HUMAN TRPM2 BOUND TO ADPR
分子名称:Transient receptor potential cation channel subfamily M member 2, ADENOSINE-5-DIPHOSPHORIBOSE
著者Du, J., Lu, W., Huang, Y.
登録日2019-07-18
公開日2019-09-25
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
6PUS
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HUMAN TRPM2 BOUND TO ADPR AND CALCIUM
分子名称:Transient receptor potential cation channel subfamily M member 2, ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION
著者Du, J., Lu, W., Huang, Y.
登録日2019-07-18
公開日2019-09-25
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
6PUU
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HUMAN TRPM2 BOUND TO 8-BR-CADPR AND CALCIUM
分子名称:Transient receptor potential cation channel subfamily M member 2, (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION
著者Du, J., Lu, W., Huang, Y.
登録日2019-07-18
公開日2019-09-25
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.
Elife, 8, 2019
6J9A
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA VAL1 IN COMPLEX WITH FLC DNA FRAGMENT
分子名称:B3 domain-containing transcription repressor VAL1, DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*TP*G)-3'), DNA (5'-D(*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*TP*C)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (2.915 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6J9B
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ARABIDOPSIS FUS3-DNA COMPLEX
分子名称:B3 domain-containing transcription factor FUS3, DNA (5'-D(*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*TP*C)-3'), DNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*TP*G)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6J9C
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA TRANSCRIPTION FACTOR LEC2-DNA COMPLEX
分子名称:B3 domain-containing transcription factor LEC2, DNA (5'-D(*GP*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*T)-3'), DNA (5'-D(*CP*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*T)-3')
著者Hu, H., Du, J.
登録日2019-01-22
公開日2019-05-29
実験手法X-RAY DIFFRACTION (3.102 Å)
主引用文献Embryonic resetting of the parental vernalized state by two B3 domain transcription factors in Arabidopsis.
Nat.Plants, 5, 2019
6NF0
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NOCTURNIN WITH BOUND NADPH SUBSTRATE
分子名称:Nocturnin, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Estrella, M.A., Du, J., Korennykh, A.
登録日2018-12-18
公開日2019-05-01
最終更新日2019-06-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The metabolites NADP+and NADPH are the targets of the circadian protein Nocturnin (Curled).
Nat Commun, 10, 2019
6IP4
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH NOG AND AN H3K27ME3 PEPTIDE
分子名称:Arabidopsis JMJ13, Histone H3.2, NICKEL (II) ION, ...
著者Hu, H., Du, J.
登録日2018-11-02
公開日2019-04-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
6IP0
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA JMJ13 CATALYTIC DOMAIN IN COMPLEX WITH AKG
分子名称:Transcription factor jumonji (Jmj) family protein, 2-OXOGLUTARIC ACID, NICKEL (II) ION, ...
著者Hu, H., Du, J.
登録日2018-11-01
公開日2019-04-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor.
Nat Commun, 10, 2019
6MO7
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-((4-(3-(N-CYCLOPENTYLSULFAMOYL)-4-METHYLPHENYL)-3-METHYLISOXAZOL-5-YL)METHYL)ACETAMIDE INHIBITOR
分子名称:Bromodomain-containing protein 2, N-({4-[3-(cyclopentylsulfamoyl)-4-methylphenyl]-3-methyl-1,2-oxazol-5-yl}methyl)acetamide
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO8
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH 4,4'-(QUINOLINE-5,7-DIYL)BIS(3,5-DIMETHYLISOXAZOLE) INHIBITOR
分子名称:Bromodomain-containing protein 2, 5,7-bis(3,5-dimethyl-1,2-oxazol-4-yl)quinoline, SULFATE ION
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MO9
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N-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH N-CYCLOPENTYL-7-(3,5-DIMETHYLISOXAZOL-4-YL)QUINOLINE-5-SULFONAMIDE INHIBITOR
分子名称:Bromodomain-containing protein 2, N-cyclopentyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-5-sulfonamide
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MOA
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C-TERMINAL BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH 4-(2-CYCLOPROPYL-7-(6-METHYLQUINOLIN-5-YL)-1H-BENZO[D]IMIDAZOL-5-YL)-3,5-DIMETHYLISOXAZOLE INHIBITOR
分子名称:Bromodomain-containing protein 2, 4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole, GLYCEROL
著者Lansdon, E.B., Newby, Z.E.R.
登録日2018-10-04
公開日2019-01-23
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (1.271 Å)
主引用文献Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
Bioorg. Med. Chem., 27, 2019
6MAL
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STRUCTURE OF HUMAN NOCTURNIN C-TERMINAL DOMAIN
分子名称:Nocturnin, MAGNESIUM ION
著者Estrella, M.A., Du, J., Korennykh, A.
登録日2018-08-28
公開日2018-09-05
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Human Nocturnin Catalytic Domain.
Sci Rep, 8, 2018
6A5K
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 1
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5M
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH SAM, FORM 2
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, ZINC ION, ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6A5N
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA SUVH6 IN COMPLEX WITH METHYLATED DNA
分子名称:Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6, DNA (5'-D(*GP*AP*GP*TP*AP*CP*TP*(5CM)P*AP*GP*CP*AP*GP*T)-3'), ...
著者Li, X., Du, J.
登録日2018-06-24
公開日2018-08-29
最終更新日2018-09-26
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DRJ
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STRUCTURE OF TRPM2 ION CHANNEL RECEPTOR BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY, ADPR/CA2+ BOUND STATE
分子名称:Transient receptor potential cation channel, subfamily M, member 2, ...
著者Du, J., Lu, W., Huang, Y., Winkler, P., Sun, W.
登録日2018-06-12
公開日2018-09-19
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Nature, 562, 2018
6DRK
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STRUCTURE OF TRPM2 ION CHANNEL RECEPTOR BY SINGLE PARTICLE ELECTRON CRYO-MICROSCOPY, APO STATE
分子名称:Transient receptor potential cation channel, subfamily M, member 2
著者Du, J., Lu, W., Huang, Y., Winkler, P., Sun, W.
登録日2018-06-12
公開日2018-09-19
最終更新日2018-10-10
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium.
Nature, 562, 2018
5ZWX
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CRYSTAL STRUCTURE OF RAPHANUS SATIVUS AGDP1 AGD12 IN COMPLEX WITH AN H3K9ME2 PEPTIDE
分子名称:DUF724 domain-containing protein 6-like, H3(1-15)K9me2 peptide
著者Du, X., Du, J.
登録日2018-05-17
公開日2018-11-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZWZ
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CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA AGDP1 AGD34
分子名称:Agenet domain-containing protein
著者Du, X., Du, J.
登録日2018-05-17
公開日2018-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Arabidopsis AGDP1 links H3K9me2 to DNA methylation in heterochromatin
Nat Commun, 9, 2018
5ZNP
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K4ME3 PEPTIDE
分子名称:SHORT LIFE family protein, 15-mer peptide from Histone H3.2, ZINC ION
著者Lv, X., Du, J.
登録日2018-04-10
公開日2018-07-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
5ZNR
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CRYSTAL STRUCTURE OF PTSHL IN COMPLEX WITH AN H3K27ME3 PEPTIDE
分子名称:SHORT LIFE family protein, 17-mer peptide from Histone H3.2, ZINC ION, ...
著者Lv, X., Du, J.
登録日2018-04-10
公開日2018-07-18
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL.
Nat Commun, 9, 2018
6CUD
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STRUCTURE OF THE HUMAN TRPC3 IN A LIPID-OCCUPIED, CLOSED STATE
分子名称:Short transient receptor potential channel 3, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (2R)-3-hydroxypropane-1,2-diyl dihexanoate, ...
著者Lu, W., Du, J., Fan, C., Choi, W.
登録日2018-03-25
公開日2018-05-16
最終更新日2018-05-23
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the human lipid-gated cation channel TRPC3.
Elife, 7, 2018