Author results

1GAG
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CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor:INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, BISUBSTRATE PEPTIDE INHIBITOR, ...
Authors:Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
1KUV
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X-RAY CRYSTALLOGRAPHIC STUDIES OF SEROTONIN N-ACETYLTRANSFERASE CATALYSIS AND INHIBITION
Descriptor:Serotonin N-acetyltransferase, MAGNESIUM ION, COA-S-ACETYL 5-BROMOTRYPTAMINE
Authors:Wolf, E., De Angelis, J., Khalil, E.M., Cole, P.A., Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1KUX
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X-RAY CRYSTALLOGRAPHIC STUDIES OF SEROTONIN N-ACETYLTRANSFERASE CATALYSIS AND INHIBITION
Descriptor:Serotonin N-acetyltransferase, COA-S-TRIMETHYLENE-ACETYL-TRYPTAMINE
Authors:Wolf, E., De Angelis, J., Khalil, E.M., Cole, P.A., Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1KUY
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X-RAY CRYSTALLOGRAPHIC STUDIES OF SEROTONIN N-ACETYLTRANSFERASE CATALYSIS AND INHIBITION
Descriptor:Serotonin N-acetyltransferase, COA-S-ACETYL TRYPTAMINE
Authors:Wolf, E., De Angelis, J., Khalil, E.M., Cole, P.A., Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1L0C
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INVESTIGATION OF THE ROLES OF CATALYTIC RESIDUES IN SEROTONIN N-ACETYLTRANSFERASE
Descriptor:Serotonin N-acetyltransferase, COA-S-ACETYL TRYPTAMINE
Authors:Scheibner, K.A., De Angelis, J., Burley, S.K., Cole, P.A.
Deposit date:2002-02-08
Release date:2002-06-19
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
J.Biol.Chem., 277, 2002
1M1D
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TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR
Descriptor:TGCN5 HISTONE ACETYL TRANSFERASE, HISTONE H3
Authors:Poux, A.N., Cebrat, M., Kim, C.M., Cole, P.A., Marmorstein, R.
Deposit date:2002-06-18
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
Proc.Natl.Acad.Sci.USA, 99, 2002
2CCH
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THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
2CCI
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CRYSTAL STRUCTURE OF PHOSPHO-CDK2 CYCLIN A IN COMPLEX WITH A PEPTIDE CONTAINING BOTH THE SUBSTRATE AND RECRUITMENT SITES OF CDC6
Descriptor:Cyclin-dependent kinase 2, Cyclin-A2, Cell division control protein 6 homolog, ...
Authors:Cheng, K.Y., Noble, M.E.M., Skamnaki, V., Brown, N.R., Lowe, E.D., Kontogiannis, L., Shen, K., Cole, P.A., Siligardi, G., Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2GS2
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CRYSTAL STRUCTURE OF THE ACTIVE EGFR KINASE DOMAIN
Descriptor:Epidermal growth factor receptor
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
2GS6
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CRYSTAL STRUCTURE OF THE ACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AN ATP ANALOG-PEPTIDE CONJUGATE
Descriptor:Epidermal growth factor receptor, Peptide, CHLORIDE ION, ...
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
2GS7
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CRYSTAL STRUCTURE OF THE INACTIVE EGFR KINASE DOMAIN IN COMPLEX WITH AMP-PNP
Descriptor:Epidermal growth factor receptor, MAGNESIUM ION, IODIDE ION, ...
Authors:Zhang, X., Gureasko, J., Shen, K., Cole, P.A., Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
2RF9
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFD
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1, SULFATE ION
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFE
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE EGFR KINASE DOMAIN AND A MIG6 PEPTIDE
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Zhang, X., Pickin, K.A., Bose, R., Jura, N., Cole, P.A., Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2UXN
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STRUCTURAL BASIS OF HISTONE DEMETHYLATION BY LSD1 REVEALED BY SUICIDE INACTIVATION
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3.1, ...
Authors:Yang, M., Culhane, J.C., Szewczuk, L.M., Gocke, C.B., Brautigam, C.A., Tomchick, D.R., Machius, M., Cole, P.A., Yu, H.
Deposit date:2007-03-28
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
Nat.Struct.Mol.Biol., 14, 2007
2UXX
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HUMAN LSD1 HISTONE DEMETHYLASE-COREST IN COMPLEX WITH AN FAD- TRANYLCYPROMINE ADDUCT
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FAD-trans-2-Phenylcyclopropylamine Adduct, ...
Authors:Yang, M., Culhane, J.C., Machius, M., Cole, P.A., Yu, H.
Deposit date:2007-03-30
Release date:2007-08-21
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.
Biochemistry, 46, 2007
3BIY
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CRYSTAL STRUCTURE OF P300 HISTONE ACETYLTRANSFERASE DOMAIN IN COMPLEX WITH A BISUBSTRATE INHIBITOR, LYS-COA
Descriptor:Histone acetyltransferase p300, BROMIDE ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
Authors:Liu, X., Wang, L., Zhao, K., Thompson, P.R., Hwang, Y., Marmorstein, R., Cole, P.A.
Deposit date:2007-12-02
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
Nature, 451, 2008
3D7T
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STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK, Proto-oncogene tyrosine-protein kinase Src, STAUROSPORINE
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3D7U
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STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK, Proto-oncogene tyrosine-protein kinase Src
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (4.111 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3GEQ
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STRUCTURAL BASIS FOR THE CHEMICAL RESCUE OF SRC KINASE ACTIVITY
Descriptor:Proto-oncogene tyrosine-protein kinase Src, 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE
Authors:Muratore, K.E., Seeliger, M.A., Wang, Z., Fomina, D., Neiswinger, J., Havranek, J.J., Baker, D., Kuriyan, J., Cole, P.A.
Deposit date:2009-02-25
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48, 2009
4PFJ
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THE STRUCTURE OF BI-ACETYLATED SAHH
Descriptor:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE
Authors:Kavran, J.M., Wang, Y., Cole, P.A., Leahy, D.J.
Deposit date:2014-04-29
Release date:2014-10-01
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
4PGF
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THE STRUCTURE OF MONO-ACETYLATED SAHH
Descriptor:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE
Authors:Kavran, J.M., Wang, Y., Cole, P.A., Leahy, D.J.
Deposit date:2014-05-01
Release date:2014-10-01
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
6BUU
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CRYSTAL STRUCTURE OF AKT1 (AA 144-480) WITH A BISUBSTRATE
Descriptor:RAC-alpha serine/threonine-protein kinase, GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, SULFATE ION, ...
Authors:Chu, N., Gabelli, S.B., Cole, P.A.
Deposit date:2017-12-11
Release date:2018-08-22
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
6NPZ
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CRYSTAL STRUCTURE OF AKT1 (AA 123-480) KINASE WITH A BISUBSTRATE
Descriptor:RAC-alpha serine/threonine-protein kinase, bisubstrate, MANGANESE (II) ION, ...
Authors:Chu, N., Cole, P.A., Gabelli, S.B.
Deposit date:2019-01-18
Release date:2019-01-30
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
3Q33
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STRUCTURE OF THE RTT109-ACCOA/VPS75 COMPLEX AND IMPLICATIONS FOR CHAPERONE-MEDIATED HISTONE ACETYLATION
Descriptor:Histone acetyltransferase RTT109, Vacuolar protein sorting-associated protein 75, HISTONE H3, ...
Authors:Tang, Y., Yuan, H., Meeth, K., Marmorstein, R.
Deposit date:2010-12-21
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation.
Structure, 19, 2011
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