2RFE
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Summary for 2RFE
Entry DOI | 10.2210/pdb2rfe/pdb |
Related | 2RF9 2RFD |
Descriptor | Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (3 entities in total) |
Functional Keywords | kinase domain, inhibition, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation, cytoplasm |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 Cytoplasm : Q9UJM3 |
Total number of polymer chains | 6 |
Total formula weight | 156370.83 |
Authors | Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. (deposition date: 2007-09-28, release date: 2007-12-04, Last modification date: 2023-08-30) |
Primary citation | Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450:741-744, 2007 Cited by PubMed: 18046415DOI: 10.1038/nature05998 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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