2RFE
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Epidermal growth factor receptor | polymer | 324 | 36966.8 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | E, F (E, F) | ERBB receptor feedback inhibitor 1 | polymer | 40 | 4251.8 | 2 | UniProt (Q9UJM3) Pfam (PF11555) | Homo sapiens | Mitogen-inducible gene 6 protein, Mig-6 |
| 3 | G, H, I, J, K (A, B, C, D, E) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 678 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 675 | - | expression tag |
| Ala 676 | - | expression tag |
| Met 677 | - | expression tag |
| Glu 799 | Lys 823 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156370.8 | |
| All* | Total formula weight | 156370.8 |
