6BUU

Crystal structure of AKT1 (aa 144-480) with a bisubstrate

Summary for 6BUU

Entry DOI	10.2210/pdb6buu/pdb
Related	6C01
Descriptor	RAC-alpha serine/threonine-protein kinase, GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, SULFATE ION, ... (5 entities in total)
Functional Keywords	akt1, rac-alpha serine/theronine-protein kinase, kinase, phosphorylated tail, semi-synthesis, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	82021.92
Authors	Chu, N.,Gabelli, S.B.,Cole, P.A. (deposition date: 2017-12-11, release date: 2018-08-22, Last modification date: 2023-11-15)
Primary citation	Chu, N.,Salguero, A.L.,Liu, A.Z.,Chen, Z.,Dempsey, D.R.,Ficarro, S.B.,Alexander, W.M.,Marto, J.A.,Li, Y.,Amzel, L.M.,Gabelli, S.B.,Cole, P.A. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell, 174:897-907.e14, 2018 Cited by PubMed: 30078705 DOI: 10.1016/j.cell.2018.07.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation