6BUU
Crystal structure of AKT1 (aa 144-480) with a bisubstrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | ASN351 |
| A | GLN352 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue MN F 501 |
| Chain | Residue |
| A | ASP292 |
| F | ZXW7 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MN G 501 |
| Chain | Residue |
| B | ASN279 |
| B | ASP292 |
| G | ZXW7 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for Ligand residues ZXW F 7 through PHE F 8 bound to THR F 6 |
| Chain | Residue |
| A | VAL164 |
| A | LYS179 |
| A | GLU228 |
| A | ALA230 |
| A | GLU234 |
| A | ASP274 |
| A | LYS276 |
| A | MET281 |
| A | ASP292 |
| A | PHE309 |
| A | CYS310 |
| A | GLY311 |
| A | THR312 |
| A | PHE438 |
| F | ARG4 |
| F | THR6 |
| F | ALA9 |
| F | MN501 |
| F | HOH601 |
| A | GLY159 |
| A | THR160 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for Ligand residues ZXW G 7 through PHE G 8 bound to THR G 6 |
| Chain | Residue |
| B | GLY159 |
| B | THR160 |
| B | VAL164 |
| B | ALA177 |
| B | LYS179 |
| B | GLU228 |
| B | ALA230 |
| B | GLU234 |
| B | ASP274 |
| B | LYS276 |
| B | MET281 |
| B | ASP292 |
| B | LEU295 |
| B | PHE309 |
| B | CYS310 |
| B | GLY311 |
| B | THR312 |
| B | PHE438 |
| G | THR6 |
| G | ALA9 |
| G | MN501 |
| G | HOH601 |
| G | HOH603 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 34 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVkekatgryyamkilkkevIVAK |
| Chain | Residue | Details |
| A | LEU156-LYS189 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKleNLML |
| Chain | Residue | Details |
| A | VAL270-LEU282 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by caspase-3","evidences":[{"source":"UniProtKB","id":"P31750","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by TNK2","evidences":[{"source":"PubMed","id":"20333297","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by IKKE, PDPK1 and TBK1","evidences":[{"source":"PubMed","id":"15718470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18456494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20333297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21464307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8978681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9512493","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"source":"PubMed","id":"22629392","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22410793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
