2GS2
Crystal Structure of the active EGFR kinase domain
Summary for 2GS2
Entry DOI | 10.2210/pdb2gs2/pdb |
Related | 2GS6 2GS7 |
Descriptor | Epidermal growth factor receptor (2 entities in total) |
Functional Keywords | egfr, kinase, active, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37563.46 |
Authors | Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. (deposition date: 2006-04-25, release date: 2006-06-20, Last modification date: 2023-08-30) |
Primary citation | Zhang, X.,Gureasko, J.,Shen, K.,Cole, P.A.,Kuriyan, J. An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell(Cambridge,Mass.), 125:1137-1149, 2006 Cited by PubMed: 16777603DOI: 10.1016/j.cell.2006.05.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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