Author results

7C2I
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CRYSTAL STRUCTURE OF NSP16-NSP10 HETERODIMER FROM SARS-COV-2 IN COMPLEX WITH SAM (WITH ADDITIONAL SAM DURING CRYSTALLIZATION)
Descriptor:Replicase polyprotein 1ab, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Lin, S., Chen, H., Ye, F., Chen, Z.M., Yang, F.L., Zheng, Y., Cao, Y., Qiao, J.X., Yang, S.Y., Lu, G.W.
Deposit date:2020-05-07
Release date:2020-05-27
Last modified:2020-06-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design
To Be Published
7C2J
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CRYSTAL STRUCTURE OF NSP16-NSP10 HETERODIMER FROM SARS-COV-2 IN COMPLEX WITH SAM (WITHOUT ADDITIONAL SAM DURING CRYSTALLIZATION)
Descriptor:Replicase polyprotein 1ab, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Lin, S., Chen, H., Ye, F., Chen, Z.M., Yang, F.L., Zheng, Y., Cao, Y., Qiao, J.X., Yang, S.Y., Lu, G.W.
Deposit date:2020-05-07
Release date:2020-05-27
Last modified:2020-06-10
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design
To Be Published
6M52
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HUMAN APO FERRITIN FROZEN ON TEM GRID WITH AMORPHOUS CARBON SUPPORTING FILM
Descriptor:Ferritin heavy chain, FE (II) ION
Authors:Huang, X., Zhang, L., Wen, Z., Chen, H., Li, S., Ji, G., Yin, C., Sun, F.
Deposit date:2020-03-09
Release date:2020-05-13
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation
To Be Published
6M54
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HUMAN APO FERRITIN FROZEN ON TEM GRID WITH AMORPHOUS NICKEL TITANIUM ALLOY SUPPORTING FILM
Descriptor:Ferritin heavy chain, FE (II) ION
Authors:Huang, X., Zhang, L., Wen, Z., Chen, H., Li, S., Ji, G., Yin, C., Sun, F.
Deposit date:2020-03-09
Release date:2020-05-13
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation
To Be Published
6W36
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CRYSTAL STRUCTURE OF FAM46C
Descriptor:Terminal nucleotidyltransferase 5C, SULFATE ION
Authors:Shang, G.J., Zhang, X.W., Chen, H., Lu, D.F.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (2.854 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 2020
6W38
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CRYSTAL STRUCTURE OF THE FAM46C/PLK4 COMPLEX
Descriptor:Terminal nucleotidyltransferase 5C, Serine/threonine-protein kinase PLK4
Authors:Chen, H., Lu, D.F., Shang, G.J., Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (4.48 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 2020
6W3I
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CRYSTAL STRUCTURE OF A FAM46C MUTANT IN COMPLEX WITH PLK4
Descriptor:Terminal nucleotidyltransferase 5C, Serine/threonine-protein kinase PLK4
Authors:Chen, H., Shang, G.J., Lu, D.F., Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (3.802 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 2020
6W3J
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CRYSTAL STRUCTURE OF THE FAM46C/PLK4/CEP192 COMPLEX
Descriptor:Terminal nucleotidyltransferase 5C, Serine/threonine-protein kinase PLK4, Centrosomal protein of 192 kDa
Authors:Chen, H., Lu, D.F., Shang, G.J., Zhang, X.W.
Deposit date:2020-03-09
Release date:2020-05-06
Last modified:2020-06-03
Method:X-RAY DIFFRACTION (4.385 Å)
Cite:Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Structure, 2020
6VXK
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CRYO-EM STRUCTURE OF THE FULL-LENGTH A39R/PLEXINC1 COMPLEX
Descriptor:Semaphorin-like protein 139, Plexin-C1, N-ACETYL-D-GLUCOSAMINE
Authors:Kuo, Y.-C., Chen, H., Shang, G., Uchikawa, E., Tian, H., Bai, X., Zhang, X.
Deposit date:2020-02-22
Release date:2020-04-29
Last modified:2020-05-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation.
Nat Commun, 11, 2020
6LS9
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CRYSTAL STRUCTURE OF BOVINE HERPESVIRUS 1 GLYCOPROTEIN D
Descriptor:Envelope glycoprotein D, N-ACETYL-D-GLUCOSAMINE
Authors:Yue, D., Chen, Z.J., Yang, F.L., Ye, F., Lin, S., Cheng, Y.W., Wang, J.C., Chen, Z.M., Lin, X., Yang, J., Chen, H., Zhang, Z.L., You, Y., Sun, H.L., Wen, A., Wang, L.L., Zheng, Y., Cao, Y., Li, Y.H., Lu, G.W.
Deposit date:2020-01-17
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.
Sci Adv, 6, 2020
6LSA
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COMPLEX STRUCTURE OF BOVINE HERPESVIRUS 1 GLYCOPROTEIN D AND BOVINE NECTIN-1 IGV
Descriptor:Nectin cell adhesion molecule 1, Envelope glycoprotein D, N-ACETYL-D-GLUCOSAMINE
Authors:Yue, D., Chen, Z.J., Yang, F.L., Ye, F., Lin, S., Cheng, Y.W., Wang, J.C., Chen, Z.M., Lin, X., Yang, J., Chen, H., Zhang, Z.L., You, Y., Sun, H.L., Wen, A., Wang, L.L., Zheng, Y., Cao, Y., Li, Y.H., Lu, G.W.
Deposit date:2020-01-17
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor.
Sci Adv, 6, 2020
6LGW
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STRUCTURE OF RABIES VIRUS GLYCOPROTEIN IN COMPLEX WITH NEUTRALIZING ANTIBODY 523-11 AT ACIDIC PH
Descriptor:scFv 523-11 VH, scFv 523-11 VL, Glycoprotein,Glycoprotein,Glycoprotein
Authors:Yang, F.L., Lin, S., Ye, F., Yang, J., Qi, J.X., Chen, Z.J., Lin, X., Wang, J.C., Yue, D., Cheng, Y.W., Chen, Z.M., Chen, H., You, Y., Zhang, Z.L., Yang, Y., Yang, M., Sun, H.L., Li, Y.H., Cao, Y., Yang, S.Y., Wei, Y.Q., Gao, G.F., Lu, G.W.
Deposit date:2019-12-06
Release date:2020-02-19
Last modified:2020-04-01
Method:X-RAY DIFFRACTION (2.9037 Å)
Cite:Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody.
Cell Host Microbe, 27, 2020
6LGX
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STRUCTURE OF RABIES VIRUS GLYCOPROTEIN AT BASIC PH
Descriptor:Glycoprotein,Glycoprotein,Glycoprotein
Authors:Yang, F.L., Lin, S., Ye, F., Yang, J., Qi, J.X., Chen, Z.J., Lin, X., Wang, J.C., Yue, D., Cheng, Y.W., Chen, Z.M., Chen, H., You, Y., Zhang, Z.L., Yang, Y., Yang, M., Sun, H.L., Li, Y.H., Cao, Y., Yang, S.Y., Wei, Y.Q., Gao, G.F., Lu, G.W.
Deposit date:2019-12-06
Release date:2020-02-19
Last modified:2020-04-01
Method:X-RAY DIFFRACTION (3.097 Å)
Cite:Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody.
Cell Host Microbe, 27, 2020
6UZ8
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CRYO-EM STRUCTURE OF HUMAN TRPC6 IN COMPLEX WITH AGONIST AM-0883
Descriptor:Short transient receptor potential channel 6, 2-[[(2~{S})-2-decanoyloxy-3-dodecanoyloxy-propoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, CHOLESTEROL HEMISUCCINATE, ...
Authors:Bai, Y., Yu, X., Huang, X., Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
6UZA
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CRYO-EM STRUCTURE OF HUMAN TRPC6 IN COMPLEX WITH ANTAGONIST AM-1473
Descriptor:Short transient receptor potential channel 6, 4-({(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl}oxy)benzonitrile, 2-[[(2~{S})-2-decanoyloxypropoxy]-oxidanyl-phosphoryl]oxyethyl-trimethyl-azanium, ...
Authors:Bai, Y., Yu, X., Huang, X., Chen, H.
Deposit date:2019-11-14
Release date:2020-03-18
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Structural basis for pharmacological modulation of the TRPC6 channel.
Elife, 9, 2020
6LAS
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO SAM
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYLMETHIONINE
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAU
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO SAH
Descriptor:RNA (54-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (3.109 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAX
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THE MUTANT SAM-VI RIBOSWITCH (U6C) BOUND TO SAM
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYLMETHIONINE
Authors:Sun, A., Ren, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAZ
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO A N-MUSTARD SAM ANALOG M1
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, MAGNESIUM ION, ...
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6UWU
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH THE INHIBITOR ZL0516
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 2-{4-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-4H-1-benzopyran-4-one
Authors:Leonard, P.G., Joseph, S.
Deposit date:2019-11-05
Release date:2020-04-15
Last modified:2020-06-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.
J.Med.Chem., 63, 2020
6UPS
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CRYSTAL STRUCTURE OF THE DEUBIQUITYLASE DOMAIN FROM THE ORIENTIA TSUTSUGAMUSHI PROTEIN OTT_1962 (OTDUB)
Descriptor:ULP_PROTEASE domain-containing protein
Authors:Ronau, J.A., Lim, C.S., Xiong, Y.
Deposit date:2019-10-18
Release date:2020-04-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Ulp1-like Deubiquitylase from the Human Pathogen Orientia tsutsugamushi with a Novel Domain of Unusually High Ubiquitin Affinity
To Be Published
6UPU
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CRYSTAL STRUCTURE OF THE ORIENTIA TSUTSUGAMUSHI OTDUB IN COMPLEX WITH THREE MOLECULES OF UBIQUITIN
Descriptor:ULP_PROTEASE domain-containing protein, Ubiquitin
Authors:Lim, C.S., Ronau, J.A., Xiong, Y.
Deposit date:2019-10-18
Release date:2020-04-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Ulp1-like Deubiquitylase from the Human Pathogen Orientia tsutsugamushi with a Novel Domain of Unusually High Ubiquitin Affinity
To Be Published
6UM5
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CRYO-EM STRUCTURE OF HIV-1 NEUTRALIZING ANTIBODY DH270 UCA3 IN COMPLEX WITH CH848 10.17DT ENV
Descriptor:CH848 10.17 DT gp120, Envelope glycoprotein gp160, DH270 UCA3 Fab Heavy Chain, ...
Authors:Acharya, P., Henderson, R.C., Saunders, K.O., Haynes, B.F.
Deposit date:2019-10-09
Release date:2019-12-18
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Science, 366, 2019
6UM6
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CRYO-EM STRUCTURE OF HIV-1 NEUTRALIZING ANTIBODY DH270.6 IN COMPLEX WITH CH848 10.17DT ENV
Descriptor:CH848 10.17DT gp120, CH848 10.17DT gp41, DH270.6 Heavy chain, ...
Authors:Acharya, P., Henderson, R.C., Saunder, K.O., Haynes, B.F.
Deposit date:2019-10-09
Release date:2019-12-18
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Science, 366, 2019
6UM7
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CRYO-EM STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY DH270.MU1 IN COMPLEX WITH CH848 10.17DT ENV
Descriptor:Envelope glycoprotein gp120, Envelope glycoprotein gp41, DH270.mu1 Fab Heavy Chain, ...
Authors:Acharya, P., Henderson, R.C., Saunders, K., Haynes, B.F.
Deposit date:2019-10-09
Release date:2019-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Science, 366, 2019