1AEY | |
1PU1 | | SOLUTION STRUCTURE OF THE HYPOTHETICAL PROTEIN MTH677 FROM METHANOTHERMOBACTER THERMAUTOTROPHICUS | | Descriptor: | Hypothetical protein MTH677 | | Authors: | Blanco, F.J., Yee, A., Campos-Olivas, R., Devos, D., Valencia, A., Arrowsmith, C.H., Rico, M. | | Deposit date: | 2003-06-23 | | Release date: | 2004-06-08 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the hypothetical protein Mth677 from Methanobacterium thermoautotrophicum: A novel {alpha}+{beta} fold
Protein Sci., 13, 2004
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2M1R | | PHD DOMAIN OF ING4 N214D MUTANT | | Descriptor: | Inhibitor of growth protein 4, ZINC ION | | Authors: | Blanco, F.J. | | Deposit date: | 2012-12-05 | | Release date: | 2012-12-26 | | Method: | SOLUTION NMR | | Cite: | Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.
Carcinogenesis, 31, 2010
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6EHT | | MODULATION OF PCNA SLIDING SURFACE BY P15PAF SUGGESTS A SUPPRESSIVE MECHANISM FOR CISPLATIN-INDUCED DNA LESION BYPASS BY POL ETA HOLOENZYME | | Descriptor: | Proliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ... | | Authors: | De March, M., Barrera-Vilarmau, S., Mentegari, E., Merino, N., Bressan, E., Maga, G., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A. | | Deposit date: | 2017-09-15 | | Release date: | 2018-08-08 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46, 2018
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4ZTD | | CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH A TRAIP PEPTIDE | | Descriptor: | Proliferating cell nuclear antigen, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, ALA-GLY-ALA-GLY-ALA | | Authors: | Montoya, G., Mortuza, G.B., Blanco, F.J., Ibanez de Opakua, A. | | Deposit date: | 2015-05-14 | | Release date: | 2015-12-16 | | Last modified: | 2016-01-13 | | Method: | X-RAY DIFFRACTION (2.199 Å) | | Cite: | TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
J.Cell Biol., 212, 2016
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6GIS | | STRUCTURAL BASIS OF HUMAN CLAMP SLIDING ON DNA | | Descriptor: | Proliferating cell nuclear antigen, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3') | | Authors: | De March, M., Merino, N., Barrera-Vilarmau, S., Crehuet, R., Onesti, S., Blanco, F.J., De Biasio, A. | | Deposit date: | 2018-05-15 | | Release date: | 2018-05-30 | | Method: | X-RAY DIFFRACTION (2.82 Å) | | Cite: | Structural basis of human PCNA sliding on DNA.
Nat Commun, 8, 2017
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2JA4 | | CRYSTAL STRUCTURE OF CD5 DOMAIN III REVEALS THE FOLD OF A GROUP B SCAVENGER CYSTEINE-RICH RECEPTOR | | Descriptor: | T-CELL SURFACE GLYCOPROTEIN CD5 | | Authors: | Rodamilans, B., Munoz, I.G., Sarrias, M.R., Lozano, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2006-11-21 | | Release date: | 2007-03-06 | | Last modified: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (2.21 Å) | | Cite: | Crystal Structure of the Third Extracellular Domain of Cd5 Reveals the Fold of a Group B Scavenger Cysteine-Rich Receptor Domain.
J.Biol.Chem., 282, 2007
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2JTO | | SOLUTION STRUCTURE OF TICK CARBOXYPEPTIDASE INHIBITOR | | Descriptor: | Carboxypeptidase inhibitor | | Authors: | Pantoja-Uceda, D., Blanco, F.J. | | Deposit date: | 2007-08-03 | | Release date: | 2008-07-15 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B.
Biochemistry, 47, 2008
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2K1J | | PLAN HOMEODOMAIN FINGER OF TUMOUR SUPRESSOR ING4 | | Descriptor: | Inhibitor of growth protein 4, ZINC ION | | Authors: | Palacios, A., Garcia, P., Padro, D., Lopez-Hernandez, E., Blanco, F.J. | | Deposit date: | 2008-03-05 | | Release date: | 2008-04-15 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4.
Febs Lett., 580, 2006
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2KG4 | | THREE-DIMENSIONAL STRUCTURE OF HUMAN GADD45ALPHA IN SOLUTION BY NMR | | Descriptor: | Growth arrest and DNA-damage-inducible protein GADD45 alpha | | Authors: | Sanchez, R., Pantoja-Uceda, D., Prieto, J., Diercks, T., Campos-Olivas, R., Blanco, F.J. | | Deposit date: | 2009-03-04 | | Release date: | 2009-03-31 | | Last modified: | 2012-02-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase
J.Biol.Chem., 285, 2010
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2O7M | | THE C-TERMINAL LOOP OF THE HOMING ENDONUCLEASE I-CREI IS ESSENTIAL FOR DNA BINDING AND CLEAVAGE. IDENTIFICATION OF A NOVEL SITE FOR SPECIFICITY ENGINEERING IN THE I-CREI SCAFFOLD | | Descriptor: | DNA endonuclease I-CreI | | Authors: | Prieto, J., Redondo, P., Padro, D., Blanco, F.J., Paques, F., Montoya, G. | | Deposit date: | 2006-12-11 | | Release date: | 2007-10-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage
Nucleic Acids Res., 35, 2007
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2VBJ | | MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS | | Descriptor: | DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ... | | Authors: | Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2007-09-14 | | Release date: | 2008-10-28 | | Last modified: | 2012-06-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
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2VBL | | MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS | | Descriptor: | DNA ENDONUCLEASE I-CREI, 5'-D(*DT*DC*DT*DG*DC*DC*DT*DT*DT*DT*DT*DT *DGP*DAP)-3', 5'-D(*DT*DT*DA*DG*DG*DA*DT*DC*DC*DT*DT*DC *DAP*DAP)-3', ... | | Authors: | Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2007-09-14 | | Release date: | 2008-10-28 | | Last modified: | 2012-06-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
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2VBN | | MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS | | Descriptor: | DNA ENDONUCLEASE I-CREI, 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP)-3', 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP)-3', ... | | Authors: | Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2007-09-14 | | Release date: | 2008-10-28 | | Last modified: | 2012-06-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
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2VBO | | MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS | | Descriptor: | DNA ENDONUCLEASE I-CREI, 5'-D(*TP*CP*TP*GP*CP*CP*TP*TP*TP*TP *TP*TP*GP*AP*AP*GP*GP*AP*TP*CP*CP*TP*AP*A)-3', 5'-D(*TP*TP*AP*GP*GP*AP*TP*CP*CP*TP *TP*CP*AP*AP*AP*AP*AP*AP*GP*GP*CP*AP*GP*A)-3', ... | | Authors: | Redondo, P., Prieto, J., Munoz, I.G., Alibes, A., Stricher, F., Serrano, L., Arnould, S., Perez, C., Cabaniols, J.P., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2007-09-14 | | Release date: | 2008-10-28 | | Last modified: | 2012-06-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular Basis of Xeroderma Pigmentosum Group C DNA Recognition by Engineered Meganucleases
Nature, 456, 2008
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2VNF | | MOLECULAR BASIS OF HISTONE H3K4ME3 RECOGNITION BY ING4 | | Descriptor: | INHIBITOR OF GROWTH PROTEIN 4, HISTONE H3, SODIUM ION, ... | | Authors: | Palacios, A., Munoz, I.G., Pantoja-Uceda, D., Marcaida, M.J., Torres, D., Martin-Garcia, J.M., Luque, I., Montoya, G., Blanco, F.J. | | Deposit date: | 2008-02-04 | | Release date: | 2008-04-01 | | Last modified: | 2016-12-28 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Molecular Basis of Histone H3K4Me3 Recognition by Ing4
J.Biol.Chem., 283, 2008
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2VS7 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH DNA AND CA | | Descriptor: | HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP *GP*TP*AP*AP*GP*TP*TP*CP*CP*GP*GP*CP*GP*CP*G)-3', 5'-D(*CP*GP*CP*GP*CP*CP*GP*GP*AP*AP *CP*TP*TP*AP*CP*CP*CP*GP*GP*CP*AP*AP*GP*GP*C)-3', ... | | Authors: | Marcaida, M.J., Prieto, J., Redondo, P., Nadra, A.D., Alibes, A., Serrano, L., Grizot, S., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2008-04-21 | | Release date: | 2008-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal Structure of I-Dmoi in Complex with its Target DNA Provides New Insights Into Meganuclease Engineering.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2VS8 | | THE CRYSTAL STRUCTURE OF I-DMOI IN COMPLEX WITH DNA AND MN | | Descriptor: | HOMING ENDONUCLEASE I-DMOI, 5'-D(*GP*CP*CP*TP*TP*GP*CP*CP*GP*GP *GP*TP*AP*A)-3', 5'-D(*GP*TP*TP*CP*CP*GP*GP*CP* DGP*DCP*DGP)-3', ... | | Authors: | Marcaida, M.J., Prieto, J., Redondo, P., Nadra, A.D., Alibes, A., Serrano, L., Grizot, S., Duchateau, P., Paques, F., Blanco, F.J., Montoya, G. | | Deposit date: | 2008-04-21 | | Release date: | 2008-11-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of I-Dmoi in Complex with its Target DNA Provides New Insights Into Meganuclease Engineering.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2XE0 | | MOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS | | Descriptor: | I-CREI V2V3 VARIANT, 24MER DNA, ACETATE ION, ... | | Authors: | Munoz, I.G., Prieto, J., Subramanian, S., Coloma, J., Redondo, P., Villate, M., Merino, N., Marenchino, M., D'Abramo, M., Gervasio, F.L., Grizot, S., Daboussi, F., Smith, J., Chion-Sotine, I., Paques, F., Duchateau, P., Alibes, A., Stricher, F., Serrano, L., Blanco, F.J., Montoya, G. | | Deposit date: | 2010-05-10 | | Release date: | 2010-09-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Molecular Basis of Engineered Meganuclease Targeting of the Endogenous Human Rag1 Locus
Nucleic Acids Res., 39, 2011
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4AFL | | THE CRYSTAL STRUCTURE OF THE ING4 DIMERIZATION DOMAIN REVEALS THE FUNCTIONAL ORGANIZATION OF THE ING FAMILY OF CHROMATIN BINDING PROTEINS. | | Descriptor: | INHIBITOR OF GROWTH PROTEIN 4 | | Authors: | Culurgioni, S., Munoz, I.G., Moreno, A., Palacios, A., Villate, M., Palmero, I., Montoya, G., Blanco, F.J. | | Deposit date: | 2012-01-19 | | Release date: | 2012-02-22 | | Last modified: | 2012-07-11 | | Method: | X-RAY DIFFRACTION (2.275 Å) | | Cite: | Crystal Structure of Inhibitor of Growth 4 (Ing4) Dimerization Domain Reveals Functional Organization of Ing Family of Chromatin-Binding Proteins.
J.Biol.Chem., 287, 2012
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4D2G | | CRYSTAL STRUCTURE OF HUMAN PCNA IN COMPLEX WITH P15 PEPTIDE | | Descriptor: | PROLIFERATING CELL NUCLEAR ANTIGEN, P15 | | Authors: | DeBiasio, A., Ibanez, A., Mortuza, G., Molina, R., Cordeiro, T.N., Castillo, F., Villate, M., Merino, N., Lelli, M., Diercks, T., Luque, I., Bernardo, P., Montoya, G., Blanco, F.J. | | Deposit date: | 2014-05-09 | | Release date: | 2015-03-18 | | Last modified: | 2015-03-25 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structure of P15(Paf)-PCNA Complex and Implications for Clamp Sliding During DNA Replication and Repair.
Nat.Commun., 6, 2015
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5A0M | | THE CRYSTAL STRUCTURE OF I-SCEI IN COMPLEX WITH ITS TARGET DNA IN THE PRESENCE OF MN | | Descriptor: | INTRON-ENCODED ENDONUCLEASE I-SCEI, 5'-D(*CP*AP*CP*GP*CP*TP*AP*GP*GP*GP*AP*TP*AP*AP)-3', 5'-D(*GP*GP*TP*AP*TP*TP*AP*CP*CP*CP*TP*GP*TP*TP *AP*TP)-3', ... | | Authors: | Prieto, J., Redondo, P., Merino, N., Villate, M., Blanco, F.J., Molina, R. | | Deposit date: | 2015-04-21 | | Release date: | 2016-05-04 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of the I-Scei Nuclease Complexed with its DsDNA Target and Three Catalytic Metal Ions.
Acta Crystallogr.,Sect.F, 72, 2016
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5A72 | | CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM CA | | Descriptor: | DNA ENDONUCLEASE I-CVUI, 24MER DNA, 5'-D(*DTP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP *DCP*GP*AP*CP*GP*TP*TP*CP*TP*GP*A)-3', ... | | Authors: | Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G. | | Deposit date: | 2015-07-02 | | Release date: | 2015-09-23 | | Last modified: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
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5A74 | | CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH ITS TARGET (SRO1.3) IN THE PRESENCE OF 2 MM MN | | Descriptor: | DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP)-3', ... | | Authors: | Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G. | | Deposit date: | 2015-07-02 | | Release date: | 2015-09-23 | | Last modified: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
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5A77 | | CRYSTAL STRUCTURE OF THE HOMING ENDONUCLEASE I-CVUI IN COMPLEX WITH I- CREI TARGET (C1221) IN THE PRESENCE OF 2 MM MG REVEALING DNA CLEAVED | | Descriptor: | DNA ENDONUCLEASE I-CVUI, 14MER DNA, 5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*DCP)-3', ... | | Authors: | Molina, R., Redondo, P., LopezMendez, B., Villate, M., Merino, N., Blanco, F.J., Valton, J., Grizot, S., Duchateau, P., Prieto, J., Montoya, G. | | Deposit date: | 2015-07-03 | | Release date: | 2015-09-23 | | Last modified: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Homing Endonuclease I-Cvui Provides a New Template for Genome Modification
J.Biol.Chem., 290, 2015
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