5ME8

N-terminal domain of the human tumor suppressor ING5

Summary for 5ME8

DescriptorInhibitor of growth protein 5, (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstumor suppressor, ing5, asymmetric dimer, transcription
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q8WYH8
Total number of polymer chains2
Total molecular weight25795.36
Authors
Roversi, P.,Blanco, F.J.,Rojas, A.L.,Buitrago, J.A.R. (deposition date: 2016-11-14, release date: 2018-03-14)
Primary citation
Rodriguez Buitrago, J.A.R.,Blanco, F.J.,Rojas, A.L.,Ormaza, G.,Roversi, P.,de Opakua, A.I.,Merino, N.,Villate, M.,Palmero, I.,Vilaseca, M.,Kypta, R.,del Mar Vivanco, M.
The tumor suppressor ING5 is a dimeric molecule with Bivalent Recognition of the H3K4me3 mark
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243102.6%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5me8
no rotation
Molmil generated image of 5me8
rotated about x axis by 90°
Molmil generated image of 5me8
rotated about y axis by 90°
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