Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme

Summary for 6EHT

DescriptorProliferating cell nuclear antigen, PCNA-associated factor, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), ... (6 entities in total)
Functional Keywordsstructural analysis, human pcna p15 dna macro complex, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains7
Total molecular weight95174.09
De March, M.,Barrera-Vilarmau, S.,Mentegari, E.,Merino, N.,Bressan, E.,Maga, G.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A. (deposition date: 2017-09-15, release date: 2018-08-08, Last modification date: 2018-10-24)
Primary citation
De March, M.,Barrera-Vilarmau, S.,Crespan, E.,Mentegari, E.,Merino, N.,Gonzalez-Magana, A.,Romano-Moreno, M.,Maga, G.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A.
p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic Acids Res., 46:9816-9828, 2018
PubMed: 30102405 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gky723
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.33112 2.8% 10.2% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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