6GIS

Structural basis of human clamp sliding on DNA

Replaces:  5L7C

Summary for 6GIS

DescriptorProliferating cell nuclear antigen, DNA (5'-D(P*AP*TP*AP*CP*GP*AP*TP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*AP*TP*CP*GP*TP*AP*T)-3'), ... (5 entities in total)
Functional Keywordsstructural analysis human pcna dna complex sliding, dna binding protein
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  P12004 P12004
Total number of polymer chains5
Total molecular weight92614.42
Authors
De March, M.,Merino, N.,Barrera-Vilarmau, S.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A. (deposition date: 2018-05-15, release date: 2018-05-30)
Primary citation
De March, M.,Merino, N.,Barrera-Vilarmau, S.,Crehuet, R.,Onesti, S.,Blanco, F.J.,De Biasio, A.
Structural basis of human PCNA sliding on DNA.
Nat Commun, 8:13935-13935, 2017
PubMed: 28071730 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms13935
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.82 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25331.6%7.7%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6gis
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Molmil generated image of 6gis
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Molmil generated image of 6gis
rotated about y axis by 90°