Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GIS

Structural basis of human clamp sliding on DNA

Replaces: 5L7C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0001673	cellular_component	male germ cell nucleus
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005652	cellular_component	nuclear lamina
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005813	cellular_component	centrosome
A	0006260	biological_process	DNA replication
A	0006272	biological_process	leading strand elongation
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006298	biological_process	mismatch repair
A	0006979	biological_process	response to oxidative stress
A	0007507	biological_process	heart development
A	0016604	cellular_component	nuclear body
A	0019899	molecular_function	enzyme binding
A	0019985	biological_process	translesion synthesis
A	0030331	molecular_function	nuclear estrogen receptor binding
A	0030337	molecular_function	DNA polymerase processivity factor activity
A	0030855	biological_process	epithelial cell differentiation
A	0030894	cellular_component	replisome
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031297	biological_process	replication fork processing
A	0032077	biological_process	positive regulation of deoxyribonuclease activity
A	0032139	molecular_function	dinucleotide insertion or deletion binding
A	0032355	biological_process	response to estradiol
A	0032405	molecular_function	MutLalpha complex binding
A	0033993	biological_process	response to lipid
A	0034644	biological_process	cellular response to UV
A	0035035	molecular_function	histone acetyltransferase binding
A	0042802	molecular_function	identical protein binding
A	0043596	cellular_component	nuclear replication fork
A	0043626	cellular_component	PCNA complex
A	0044849	biological_process	estrous cycle
A	0044877	molecular_function	protein-containing complex binding
A	0045739	biological_process	positive regulation of DNA repair
A	0045740	biological_process	positive regulation of DNA replication
A	0046686	biological_process	response to cadmium ion
A	0070062	cellular_component	extracellular exosome
A	0070182	molecular_function	DNA polymerase binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070557	cellular_component	PCNA-p21 complex
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071548	biological_process	response to dexamethasone
A	0097421	biological_process	liver regeneration
A	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
A	1902065	biological_process	response to L-glutamate
A	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
B	0000781	cellular_component	chromosome, telomeric region
B	0000785	cellular_component	chromatin
B	0001673	cellular_component	male germ cell nucleus
B	0003677	molecular_function	DNA binding
B	0003682	molecular_function	chromatin binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005652	cellular_component	nuclear lamina
B	0005654	cellular_component	nucleoplasm
B	0005657	cellular_component	replication fork
B	0005813	cellular_component	centrosome
B	0006260	biological_process	DNA replication
B	0006272	biological_process	leading strand elongation
B	0006275	biological_process	regulation of DNA replication
B	0006281	biological_process	DNA repair
B	0006287	biological_process	base-excision repair, gap-filling
B	0006298	biological_process	mismatch repair
B	0006979	biological_process	response to oxidative stress
B	0007507	biological_process	heart development
B	0016604	cellular_component	nuclear body
B	0019899	molecular_function	enzyme binding
B	0019985	biological_process	translesion synthesis
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0030337	molecular_function	DNA polymerase processivity factor activity
B	0030855	biological_process	epithelial cell differentiation
B	0030894	cellular_component	replisome
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031297	biological_process	replication fork processing
B	0032077	biological_process	positive regulation of deoxyribonuclease activity
B	0032139	molecular_function	dinucleotide insertion or deletion binding
B	0032355	biological_process	response to estradiol
B	0032405	molecular_function	MutLalpha complex binding
B	0033993	biological_process	response to lipid
B	0034644	biological_process	cellular response to UV
B	0035035	molecular_function	histone acetyltransferase binding
B	0042802	molecular_function	identical protein binding
B	0043596	cellular_component	nuclear replication fork
B	0043626	cellular_component	PCNA complex
B	0044849	biological_process	estrous cycle
B	0044877	molecular_function	protein-containing complex binding
B	0045739	biological_process	positive regulation of DNA repair
B	0045740	biological_process	positive regulation of DNA replication
B	0046686	biological_process	response to cadmium ion
B	0070062	cellular_component	extracellular exosome
B	0070182	molecular_function	DNA polymerase binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070557	cellular_component	PCNA-p21 complex
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071548	biological_process	response to dexamethasone
B	0097421	biological_process	liver regeneration
B	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
B	1902065	biological_process	response to L-glutamate
B	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
C	0000701	molecular_function	purine-specific mismatch base pair DNA N-glycosylase activity
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0001673	cellular_component	male germ cell nucleus
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005652	cellular_component	nuclear lamina
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005813	cellular_component	centrosome
C	0006260	biological_process	DNA replication
C	0006272	biological_process	leading strand elongation
C	0006275	biological_process	regulation of DNA replication
C	0006281	biological_process	DNA repair
C	0006287	biological_process	base-excision repair, gap-filling
C	0006298	biological_process	mismatch repair
C	0006979	biological_process	response to oxidative stress
C	0007507	biological_process	heart development
C	0016604	cellular_component	nuclear body
C	0019899	molecular_function	enzyme binding
C	0019985	biological_process	translesion synthesis
C	0030331	molecular_function	nuclear estrogen receptor binding
C	0030337	molecular_function	DNA polymerase processivity factor activity
C	0030855	biological_process	epithelial cell differentiation
C	0030894	cellular_component	replisome
C	0030971	molecular_function	receptor tyrosine kinase binding
C	0031297	biological_process	replication fork processing
C	0032077	biological_process	positive regulation of deoxyribonuclease activity
C	0032139	molecular_function	dinucleotide insertion or deletion binding
C	0032355	biological_process	response to estradiol
C	0032405	molecular_function	MutLalpha complex binding
C	0033993	biological_process	response to lipid
C	0034644	biological_process	cellular response to UV
C	0035035	molecular_function	histone acetyltransferase binding
C	0042802	molecular_function	identical protein binding
C	0043596	cellular_component	nuclear replication fork
C	0043626	cellular_component	PCNA complex
C	0044849	biological_process	estrous cycle
C	0044877	molecular_function	protein-containing complex binding
C	0045739	biological_process	positive regulation of DNA repair
C	0045740	biological_process	positive regulation of DNA replication
C	0046686	biological_process	response to cadmium ion
C	0070062	cellular_component	extracellular exosome
C	0070182	molecular_function	DNA polymerase binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070557	cellular_component	PCNA-p21 complex
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071548	biological_process	response to dexamethasone
C	0097421	biological_process	liver regeneration
C	1900264	biological_process	positive regulation of DNA-directed DNA polymerase activity
C	1902065	biological_process	response to L-glutamate
C	1902990	biological_process	mitotic telomere maintenance via semi-conservative replication

Functional Information from PROSITE/UniProt

site_id	PS00293
Number of Residues	19
Details	PCNA_2 Proliferating cell nuclear antigen signature 2. RCDRnlaMgvnLtSMsKIL

Chain	Residue	Details
A	ARG61-LEU79

site_id	PS01251
Number of Residues	24
Details	PCNA_1 Proliferating cell nuclear antigen signature 1. GVnLqSMDsSHVsLVqLtLrsegF

Chain	Residue	Details
A	GLY34-PHE57

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA_BIND: DNA_BIND => ECO:0000255

Chain	Residue	Details
A	ARG61-LYS80
B	ARG61-LYS80
C	ARG61-LYS80

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:19419956

Chain	Residue	Details
A	LYS14
B	LYS14
C	LYS14

site_id	SWS_FT_FI3
Number of Residues	9
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS77
A	LYS80
A	LYS248
B	LYS77
B	LYS80
B	LYS248
C	LYS77
C	LYS80
C	LYS248

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by EGFR => ECO:0000269\|PubMed:17115032, ECO:0000269\|PubMed:38459011

Chain	Residue	Details
A	TYR211
B	TYR211
C	TYR211

site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269\|PubMed:17108083, ECO:0000269\|PubMed:17130289

Chain	Residue	Details
A	LYS164
B	LYS164
C	LYS164

site_id	SWS_FT_FI6
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS254
B	LYS254
C	LYS254

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)