4AFL

The crystal structure of the ING4 dimerization domain reveals the functional organization of the ING family of chromatin binding proteins.

Summary for 4AFL

Related2VNF
DescriptorINHIBITOR OF GROWTH PROTEIN 4 (2 entities in total)
Functional Keywordscell cycle, tumour suppressor, chromatin remodelling
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus Q9UNL4
Total number of polymer chains6
Total molecular weight74407.46
Authors
Culurgioni, S.,Munoz, I.G.,Moreno, A.,Palacios, A.,Villate, M.,Palmero, I.,Montoya, G.,Blanco, F.J. (deposition date: 2012-01-19, release date: 2012-02-22, Last modification date: 2012-07-11)
Primary citation
Culurgioni, S.,Munoz, I.G.,Moreno, A.,Palacios, A.,Villate, M.,Palmero, I.,Montoya, G.,Blanco, F.J.
Crystal Structure of Inhibitor of Growth 4 (Ing4) Dimerization Domain Reveals Functional Organization of Ing Family of Chromatin-Binding Proteins.
J.Biol.Chem., 287:10876-, 2012
PubMed: 22334692 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M111.330001
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.275 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25140.2%3.9%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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