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4MDH
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REFINED CRYSTAL STRUCTURE OF CYTOPLASMIC MALATE DEHYDROGENASE AT 2.5-ANGSTROMS RESOLUTION
Descriptor:CYTOPLASMIC MALATE DEHYDROGENASE, SULFATE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Birktoft, J.J., Banaszak, L.J.
Deposit date:1989-04-12
Release date:1989-04-19
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution.
Biochemistry, 28, 1989
2CHA
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THE STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN, $V.THE ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 ANGSTROMS RESOLUTION
Descriptor:ALPHA-CHYMOTRYPSIN A, PARA-TOLUENE SULFONATE
Authors:Birktoft, J.J., Blow, D.M.
Deposit date:1975-01-01
Release date:1977-01-18
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of crystalline -chymotrypsin. V. The atomic structure of tosyl- -chymotrypsin at 2 A resolution.
J.Mol.Biol., 68, 1972
3GBI
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THE RATIONAL DESIGN AND STRUCTURAL ANALYSIS OF A SELF-ASSEMBLED THREE-DIMENSIONAL DNA CRYSTAL
Descriptor:DNA (5'-D(*GP*AP*GP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*GP*GP*CP*TP*GP*C)-3'), ...
Authors:Birktoft, J.J., Zheng, J., Seeman, N.C.
Deposit date:2009-02-19
Release date:2009-09-01
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (4.018 Å)
Cite:From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal.
Nature, 461, 2009
1SBT
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ATOMIC COORDINATES FOR SUBTILISIN BPN (OR NOVO)
Descriptor:SUBTILISIN BPN'
Authors:Alden, R.A., Birktoft, J.J., Kraut, J., Robertus, J.D., Wright, C.S.
Deposit date:1972-08-11
Release date:1977-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Atomic coordinates for subtilisin BPN' (or Novo).
Biochem.Biophys.Res.Commun., 45, 1971
1BMD
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DETERMINANTS OF PROTEIN THERMOSTABILITY OBSERVED IN THE 1.9 ANGSTROMS CRYSTAL STRUCTURE OF MALATE DEHYDROGENASE FROM THE THERMOPHILIC BACTERIUM THERMUS FLAVUS
Descriptor:MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kelly, C.A., Birktoft, J.J.
Deposit date:1992-11-10
Release date:1994-07-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.
Biochemistry, 32, 1993
1MLD
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REFINED STRUCTURE OF MITOCHONDRIAL MALATE DEHYDROGENASE FROM PORCINE HEART AND THE CONSENSUS STRUCTURE FOR DICARBOXYLIC ACID OXIDOREDUCTASES
Descriptor:MALATE DEHYDROGENASE, CITRIC ACID
Authors:Gleason, W.B., Fu, Z., Birktoft, J.J., Banaszak, L.J.
Deposit date:1994-01-24
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases.
Biochemistry, 33, 1994
1BDM
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THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY
Descriptor:MALATE DEHYDROGENASE, BETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
Authors:Kelly, C.A., Birktoft, J.J.
Deposit date:1993-02-16
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus.
Biochemistry, 32, 1993
3HDH
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PIG HEART SHORT CHAIN L-3-HYDROXYACYL COA DEHYDROGENASE REVISITED: SEQUENCE ANALYSIS AND CRYSTAL STRUCTURE DETERMINATION
Descriptor:PROTEIN (L-3-HYDROXYACYL COA DEHYDROGENASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Barycki, J.J., O'Brien, L.K., Birktoft, J.J., Strauss, A.W., Banaszak, L.J.
Deposit date:1999-04-13
Release date:1999-10-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pig heart short chain L-3-hydroxyacyl-CoA dehydrogenase revisited: sequence analysis and crystal structure determination.
Protein Sci., 8, 1999
3UBI
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THE ABSENCE OF TERTIARY INTERACTIONS IN A SELF-ASSEMBLED DNA CRYSTAL STRUCTURE
Descriptor:DNA (5'-D(*GP*AP*GP*CP*AP*GP*CP*CP*CP*GP*TP*AP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*CP*GP*AP*GP*TP*AP*CP*GP*AP*CP*GP*AP*CP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*AP*GP*GP*CP*TP*GP*C)-3'), ...
Authors:Nguyen, N., Birktoft, J.J., Sha, R., Wang, T., Zheng, J., Constantinou, P.E., Ginell, S.L., Chen, Y., Mao, C., Seeman, N.C.
Deposit date:2011-10-24
Release date:2012-05-16
Method:X-RAY DIFFRACTION (6.8046 Å)
Cite:The absence of tertiary interactions in a self-assembled DNA crystal structure.
J.Mol.Recognit., 25, 2012
1C3I
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HUMAN STROMELYSIN-1 CATALYTIC DOMAIN COMPLEXED WITH RO-26-2812
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Steele, D.L., Kammlott, R.U., Crowther, R.L., Birktoft, J.J., Dunten, P., Engler, J.E.
Deposit date:1999-07-27
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1.
Protein Eng., 13, 2000
1HPG
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A GLUTAMIC ACID SPECIFIC SERINE PROTEASE UTILIZES A NOVEL HISTIDINE TRIAD IN SUBSTRATE BINDING
Descriptor:Glutamic acid specific protease, BOC-ALA-ALA-PRO-GLU PEPTIDE
Authors:Nienaber, V.L., Birktoft, J.J.
Deposit date:1993-04-28
Release date:1995-07-10
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding.
Biochemistry, 32, 1993
1N5Y
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
Descriptor:5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3', REVERSE TRANSCRIPTASE, ...
Authors:Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, P., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2002-11-07
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of HIV-1 Reverse Transcriptase with Pre-Translocation and Post-Translocation AZTMP-Terminated DNA
Embo J., 21, 2002
1N6Q
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX N)
Descriptor:5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3', Reverse Transcriptase, ...
Authors:Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, I., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2002-11-11
Release date:2003-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of HIV-1 Reverse Transcriptase with Pre- and Post-translocation AZTMP-terminated DNA
Embo J., 21, 2002
1P1Y
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CRYSTAL STRUCTURE OF A CONTINUOUS THREE-DIMENSIONAL DNA LATTICE FROM D(GGACAGATGGGAG)
Descriptor:5'-D(*GP*GP*AP*(CBR)P*AP*GP*AP*(BRU)P*GP*GP*GP*AP*G)-3', MAGNESIUM ION
Authors:Paukstelis, P.J., Nowakowski, J., Birktoft, J.J., Seeman, N.C.
Deposit date:2003-04-14
Release date:2004-06-01
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a continuous three-dimensional DNA lattice.
Chem.Biol., 11, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3N4M
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E. COLI RNA POLYMERASE ALPHA SUBUNIT C-TERMINAL DOMAIN IN COMPLEX WITH CAP AND DNA
Descriptor:Catabolite gene activator, DNA-directed RNA polymerase subunit alpha, DNA (5'-D(*CP*TP*TP*TP*TP*TP*TP*CP*CP*TP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ...
Authors:Lara-Gonzalez, S., Birktoft, J.J., Lawson, C.L.
Deposit date:2010-05-21
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.987 Å)
Cite:Combined structural model for a transcription activation assembly
To be Published
3N97
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RNA POLYMERASE ALPHA C-TERMINAL DOMAIN (E. COLI) AND SIGMA REGION 4 (T. AQ. MUTANT) BOUND TO (UP,-35 ELEMENT) DNA
Descriptor:RNA polymerase sigma factor, DNA-directed RNA polymerase subunit alpha, DNA (5'-D(*TP*GP*GP*AP*AP*AP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*CP*AP*TP*GP*G)-3'), ...
Authors:Lara-Gonzalez, S., Birktoft, J.J., Lawson, C.L.
Deposit date:2010-05-28
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.252 Å)
Cite:Combined structural model for a transcription activation assembly
To be Published
4EV0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS CATABOLITE ACTIVATOR PROTEIN
Descriptor:Transcription regulator, Crp family, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ...
Authors:Hudson, B.P., Turo, K., Birktoft, J.J., Lawson, C.L.
Deposit date:2012-04-25
Release date:2012-06-20
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Crystal Structure of T. thermophilius Catabolite Activator Protein
To be Published
5EOS
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CRYSTALLIZING STRAINED DNA: SELF-ASSEMBLY OF 3D CRYSTALS CONTAINING A TORSIONALLY-STRESSED COMPONENT
Descriptor:DNA (5'-D(P*GP*AP*GP*CP*AP*GP*CP*TP*GP*TP*G)-3'), DNA (5'-D(P*CP*AP*CP*AP*CP*CP*GP*T)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*TP*GP*TP*GP*CP*TP*GP*C)-3'), ...
Authors:Hernandez, C., Birktoft, J.J., Seeman, N.C.
Deposit date:2015-11-10
Release date:2017-08-09
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Self-Assembly of 3D DNA Crystals Containing a Torsionally Stressed Component.
Cell Chem Biol, 2017
5KEK
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STRUCTURE DETERMINATION OF A SELF-ASSEMBLING DNA CRYSTAL
Descriptor:DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*CP*TP*CP*A)-3'), DNA (5'-D(P*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*GP*T)-3'), ...
Authors:Simmons, C.R., Birktoft, J.J., Seeman, N.C., Yan, H.
Deposit date:2016-06-09
Release date:2016-08-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.098 Å)
Cite:Construction and Structure Determination of a Three-Dimensional DNA Crystal.
J.Am.Chem.Soc., 138, 2016
5KEO
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STRUCTURE DETERMINATION OF A SELF-ASSEMBLING DNA CRYSTAL
Descriptor:DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*CP*TP*CP*A)-3'), DNA (5'-D(P*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*GP*T)-3'), ...
Authors:Simmons, C.R., Birktoft, J.J., Seeman, N.C., Yan, H.
Deposit date:2016-06-09
Release date:2016-08-10
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Construction and Structure Determination of a Three-Dimensional DNA Crystal.
J.Am.Chem.Soc., 138, 2016
5W6W
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DESIGNING HIGHER RESOLUTION SELF-ASSEMBLED 3D DNA CRYSTALS VIA STRAND TERMINUS MODIFICATIONS
Descriptor:DNA (5'-D(*GP*AP*GP*CP*AP*GP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), DNA (5'-D(P*CP*CP*GP*TP*AP*CP*A)-3'), DNA (5'-D(P*GP*GP*CP*TP*GP*CP*T)-3'), ...
Authors:Hernandez, C., Birktoft, J.J., Seeman, N.C.
Deposit date:2017-06-17
Release date:2018-06-27
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Designing Higher Resolution Self-Assembled 3D DNA Crystals via Strand Terminus Modifications
To Be Published
5MDH
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CRYSTAL STRUCTURE OF TERNARY COMPLEX OF PORCINE CYTOPLASMIC MALATE DEHYDROGENASE ALPHA-KETOMALONATE AND TNAD AT 2.4 ANGSTROMS RESOLUTION
Descriptor:MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ALPHA-KETOMALONIC ACID
Authors:Chapman, A.D.M., Cortes, A., Dafforn, T.R., Clarke, A.R., Brady, R.L.
Deposit date:1998-10-08
Release date:1999-05-18
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of substrate specificity in malate dehydrogenases: crystal structure of a ternary complex of porcine cytoplasmic malate dehydrogenase, alpha-ketomalonate and tetrahydoNAD.
J.Mol.Biol., 285, 1999
1WZE
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STRUCTURAL BASIS FOR ALTERATION OF COFACTOR SPECIFICITY OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS
Descriptor:Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tomita, T., Fushinobu, S., Kuzuyama, T., Nishiyama, M.
Deposit date:2005-03-04
Release date:2006-03-14
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for alteration of cofactor specificity of malate dehydrogenase from Thermus flavus
to be published
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