1N5Y

HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)

Summary for 1N5Y

Related1HYS 2HMI 1RTD
Descriptor5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3', REVERSE TRANSCRIPTASE, ... (7 entities in total)
Functional Keywordshiv, translocation, nucleotide excision, drug resistance, complex p, transferase-immune system-dna complex, transferase/immune system/dna
Biological sourceHuman immunodeficiency virus 1
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03366 P03366
Total number of polymer chains6
Total molecular weight176776.84
Authors
Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, P.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E. (deposition date: 2002-11-07, release date: 2003-01-28, Last modification date: 2011-07-13)
Primary citation
Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, P.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E.
Structure of HIV-1 Reverse Transcriptase with Pre-Translocation and Post-Translocation AZTMP-Terminated DNA
Embo J., 21:6614-6624, 2002
PubMed: 12456667 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/cdf637
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.282446.1%14.6%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution