1N5Y

HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	T	5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'	polymer	27	8367.4	1
2	P	5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'	polymer	21	6490.3	1
3	A	REVERSE TRANSCRIPTASE	polymer	558	64249.7	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
4	B	REVERSE TRANSCRIPTASE	polymer	430	50281.8	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
5	L	monoclonal antibody (light chain)	polymer	211	23362.7	1	Pfam (PF07654) UniProt (by SIFTS) (P01837) In PDB	Mus musculus (house mouse)
6	H	monoclonal antibody (heavy chain)	polymer	225	24000.8	1	Pfam (PF07654) UniProt (by SIFTS) (P01868) In PDB	Mus musculus (house mouse)
7	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 558 (UniProt: P03366)

PDB	External Database	Details
Cys 258	Gln 425	engineered mutation
Ser 280	Cys 447	engineered mutation

B: 1 - 430 (UniProt: P03366)

PDB	External Database	Details
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	176752.5
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	176776.8

*Water molecules are not included.