1N5Y
HIV-1 Reverse Transcriptase Crosslinked to Post-Translocation AZTMP-Terminated DNA (Complex P)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (T) | 5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3' | polymer | 27 | 8367.4 | 1 | |||
| 2 | B (P) | 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3' | polymer | 21 | 6490.3 | 1 | |||
| 3 | C (A) | REVERSE TRANSCRIPTASE | polymer | 558 | 64249.7 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | HIV-1 RT |
| 4 | D (B) | REVERSE TRANSCRIPTASE | polymer | 430 | 50281.8 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus 1 | HIV-1 RT |
| 5 | E (L) | monoclonal antibody (light chain) | polymer | 211 | 23362.7 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01837) | Mus musculus (house mouse) | |
| 6 | F (H) | monoclonal antibody (heavy chain) | polymer | 225 | 24000.8 | 1 | Pfam (PF07654) UniProt (by SIFTS) (P01868) | Mus musculus (house mouse) | |
| 7 | G (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 558 (UniProt: P03366)
B: 1 - 430 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Cys 258 | Gln 425 | engineered mutation |
| Ser 280 | Cys 447 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 447 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 176752.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 176776.8 |
