1HYS
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
Summary for 1HYS
Entry DOI | 10.2210/pdb1hys/pdb |
Related | 1DLO 1RTD 2HMI |
Descriptor | 5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3', HIV-1 REVERSE TRANSCRIPTASE, ... (6 entities in total) |
Functional Keywords | polypurine tract, ppt, protein-nucleic acid complex, rnase h, rna:dna, unpaired base, rnase h primer grip, transferase-dna-rna complex, transferase-dna-rna hybrid complex, transferase/dna-rna hybrid |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 6 |
Total formula weight | 173779.96 |
Authors | Sarafianos, S.G.,Das, K.,Tantillo, C.,Clark Jr., A.D.,Ding, J.,Whitcomb, J.,Boyer, P.L.,Hughes, S.H.,Arnold, E. (deposition date: 2001-01-22, release date: 2001-03-26, Last modification date: 2023-08-09) |
Primary citation | Sarafianos, S.G.,Das, K.,Tantillo, C.,Clark Jr., A.D.,Ding, J.,Whitcomb, J.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E. Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. EMBO J., 20:1449-1461, 2001 Cited by PubMed: 11250910DOI: 10.1093/emboj/20.6.1449 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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